Protein Alignment TkR99D and Pgr15l

DIOPT Version :10

• Sequence 1: NP_001263092.1
• Gene: TkR99D / 43551
• FlyBaseID: FBgn0004622
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001100053.1
• Gene: Pgr15l / 296867
• RGDID: 1562685
• Length: 456
• Species: Rattus norvegicus
• Alignment Length: 473
• Identity: 118/473 - (24%)
• Similarity: 211/473 - (44%)
• Gaps: 70/473 - (14%)

  Fly    54 ALSTSSFNHSQTLSTDLPAVGDVEDAAEDAAASMETGSFAFVVPWW--------RQVLWSILFGG 110
            ::...|.||:....|::              :|.|.|.....|..|        .:::.:..:..
  Rat    31 SIEDQSCNHTTQNGTNI--------------SSAEWGGPRGTVTKWLGGNPHIMAKIVLTFAYAV 81

  Fly   111 MVIVATGGNLIVVWIVMTTKRMRTVTNYFIVNLSIADAMVSSLNVTFNYYYMLDSDWPFGEFYCK 175
            :::::..||.:|..:.:..|..:..|...|.||:|:|.::..||..|.....|...|.||...|.
  Rat    82 IIVISLFGNSLVCQVFVKHKETKKSTGLLIFNLAISDILIILLNSPFALARFLSGQWVFGRIMCH 146

  Fly   176 LSQFIAMLSICASVFTLMAISIDRYVAIIRPLQPRMSKRCNLAIAAVIWLASTLISCPMMIIYRT 240
            :|:|....|:..|..||||:::||:..|:.|::||::...:|.:..|||..:..::.|..|....
  Rat   147 VSRFAQYCSLHVSTLTLMAVAMDRHRVILHPMKPRLTHSQSLFVVGVIWSIAVFLALPHAIYQNL 211

  Fly   241 EEVPVRGLSNRTVCYPEWPDGPTNHSTMESLY-NILIIILTYFLPIVSMTVTYSRVGIELWGSKT 304
            ..:.......|:.|.|.:| ||   ||:.|.| ::...||.|.||::.:..|||.:|..||....
  Rat   212 FTLVNMDGDVRSYCLPSFP-GP---STLVSKYVDLGTFILLYILPLLVIVGTYSHLGKRLWIQNA 272

  Fly   305 IGECTPRQ-VENVRSKRRVVKMMIVVVLIFAICWLPFHSYFIITSCYPAITEAPFIQELYLAIYW 368
            ||:.:.|| :.:.:.:::.::|:|::||:||:||.|.:.|.::.|......::    .::.|.:|
  Rat   273 IGDASARQLMAHYQKRKKSIRMLILIVLVFAVCWFPLNFYVVLISSAGVENDS----VIFYAFHW 333

  Fly   369 LAMSNSMYNPIIYCWMNSRFRYGFKMV--FRWCLFVRVGTEPFSRRENLTSRYSCSGSPDHNRIK 431
            .|||::.|||.||||:|..||...:.:  ||                 :.|.:.||.|.......
  Rat   334 FAMSSTCYNPFIYCWLNRSFRAKLRSISSFR-----------------MQSLFVCSSSQVQQIQP 381

  Fly   432 RNDTQKSILYTCPSSPKSHRISHSGTGRSATLRNSLPAESLSSGGSGGGGHRKRLSYQQEMQQRW 496
            |               :||.:....|.....:..::|...:....|...|...::|.|.|    |
  Rat   382 R---------------ESHELRELRTSSLLRVPLAVPEPQVFEDPSLATGDNSQVSVQGE----W 427

  Fly   497 SGPNSATAVTNSSSTANT 514
            ..|:.:.......||.::
  Rat   428 EDPDPSLDEEPGPSTRDS 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR99D	NP_001263092.1	7tmA_TACR	102..392	CDD:320512	89/291 (31%)
		TM helix 1	103..129	CDD:320512	3/25 (12%)
		TM helix 2	136..162	CDD:320512	9/25 (36%)
		TM helix 3	174..204	CDD:320512	11/29 (38%)
		TM helix 4	215..236	CDD:320512	5/20 (25%)
		TM helix 5	269..298	CDD:320512	11/29 (38%)
		TM helix 6	317..347	CDD:320512	10/29 (34%)
		TM helix 7	360..385	CDD:320512	12/24 (50%)
Pgr15l	NP_001100053.1	7tmA_GPR83	73..357	CDD:320511	89/291 (31%)
		TM helix 1	74..100	CDD:320511	3/25 (12%)
		TM helix 2	107..132	CDD:320511	9/24 (38%)
		TM helix 3	145..175	CDD:320511	11/29 (38%)
		TM helix 4	186..207	CDD:320511	5/20 (25%)
		TM helix 5	237..266	CDD:320511	11/28 (39%)
		TM helix 6	286..316	CDD:320511	10/29 (34%)
		TM helix 7	325..350	CDD:320511	12/28 (43%)