Protein Alignment TkR99D and Oprl1

DIOPT Version :10

• Sequence 1: NP_001263092.1
• Gene: TkR99D / 43551
• FlyBaseID: FBgn0004622
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001305876.1
• Gene: Oprl1 / 29256
• RGDID: 68438
• Length: 396
• Species: Rattus norvegicus
• Alignment Length: 355
• Identity: 94/355 - (26%)
• Similarity: 160/355 - (45%)
• Gaps: 82/355 - (23%)

  Fly   105 SILFGGMVIVATGGNLIVVWIVMTTKRMRTVTNYFIVNLSIADAMVSSLNVTFNYYYMLDSDWPF 169
            ::..||::     ||.:|:::::...:|:|.||.:|.||::||.:| .|.:.|....:|...|||
  Rat    57 AVCIGGLL-----GNCLVMYVILRHTKMKTATNIYIFNLALADTLV-LLTLPFQGTDILLGFWPF 115

  Fly   170 GEFYCKLSQFIAMLSICASVFTLMAISIDRYVAI---IRPLQPRMSKRCNLAIAAVIWLASTLIS 231
            |...||....|...::..|.|||.|:|:||||||   ||.|..|.|.:.. |:...||..::::.
  Rat   116 GNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQ-AVNVAIWALASVVG 179

  Fly   232 CPMMII----YRTEEVPVRGLSNRTVCYPEWPD-----GPTNHSTMESLYNILIIILTYFLPIVS 287
            .|:.|:    ...||:.         |..|.|.     ||        ::.|.|.:.::.:|::.
  Rat   180 VPVAIMGSAQVEDEEIE---------CLVEIPAPQDYWGP--------VFAICIFLFSFIIPVLI 227

  Fly   288 MTVTYSRV-----GIELW-GSKTIGECTPRQVENVRSKRRVVKMMIVVVLIFAICWLPFHSYFII 346
            ::|.||.:     |:.|. ||:          |..|:.||:.::::|||.:|..||.|...:.::
  Rat   228 ISVCYSLMIRRLRGVRLLSGSR----------EKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLV 282

  Fly   347 --TSCYPAITEAPFIQELYLAIYWLAMSNSMYNPIIYCWMNSRFRYGFKMVFRWCLFVRVGTEPF 409
              ....|....|..|.....|:.::   ||..|||:|.:::..|:..|
  Rat   283 QGLGVQPGSETAVAILRFCTALGYV---NSCLNPILYAFLDENFKACF----------------- 327

  Fly   410 SRRENLTSRYSCSGSPDHNRIKRNDTQKSI 439
                    |..|..|..|..::.:|..:||
  Rat   328 --------RKFCCASSLHREMQVSDRVRSI 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR99D	NP_001263092.1	7tmA_TACR	102..392	CDD:320512	86/306 (28%)
		TM helix 1	103..129	CDD:320512	5/23 (22%)
		TM helix 2	136..162	CDD:320512	10/25 (40%)
		TM helix 3	174..204	CDD:320512	15/32 (47%)
		TM helix 4	215..236	CDD:320512	4/20 (20%)
		TM helix 5	269..298	CDD:320512	7/33 (21%)
		TM helix 6	317..347	CDD:320512	10/31 (32%)
		TM helix 7	360..385	CDD:320512	7/24 (29%)
Oprl1	NP_001305876.1	7tmA_NOFQ_opioid_R	49..327	CDD:320220	86/306 (28%)
		TM helix 1	50..76	CDD:320220	5/23 (22%)
		TM helix 2	83..109	CDD:320220	10/26 (38%)
		TM helix 3	120..150	CDD:320220	14/29 (48%)
		TM helix 4	162..184	CDD:320220	4/22 (18%)
		TM helix 5	209..238	CDD:320220	8/36 (22%)
		TM helix 6	253..283	CDD:320220	10/29 (34%)
		TM helix 7	295..320	CDD:320220	8/27 (30%)