Protein Alignment TkR99D and Galr3

DIOPT Version :10

• Sequence 1: NP_001263092.1
• Gene: TkR99D / 43551
• FlyBaseID: FBgn0004622
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_062046.1
• Gene: Galr3 / 29235
• RGDID: 2658
• Length: 370
• Species: Rattus norvegicus
• Alignment Length: 432
• Identity: 115/432 - (26%)
• Similarity: 183/432 - (42%)
• Gaps: 97/432 - (22%)

  Fly    73 VGDVEDAAEDAAASMETGSFAFVVPWWRQVLWSILF-GGMVIVATGGNLIVVWIVM-----TTKR 131
            :.|:::.:.|:..|:.    |..||    |:::::| .|||     ||.:|:.:::     ..:.
  Rat     1 MADIQNISLDSPGSVG----AVAVP----VIFALIFLLGMV-----GNGLVLAVLLQPGPSAWQE 52

  Fly   132 MRTVTNYFIVNLSIADAMVSSLNVTFN-YYYMLDSDWPFGEFYCKLSQFIAMLSICASVFTLMAI 195
            ..:.|:.||:||::||.......|.|. ..|.||: |.||.|.||....:..|::.||.|||.|:
  Rat    53 PSSTTDLFILNLAVADLCFILCCVPFQAAIYTLDA-WLFGAFVCKTVHLLIYLTMYASSFTLAAV 116

  Fly   196 SIDRYVAIIRPLQPRMSKRCNLAIAAV--IWLASTLISCPMMIIYRTEEVPVRGLSNRTVCYPEW 258
            |:|||:|:..||:.|..:....|.|||  :||.:.|.|.|.:..|.|.......|     |.|.|
  Rat   117 SLDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALEL-----CVPAW 176

  Fly   259 PDGPTNHSTMESLYNILIIILTYFLPIVSMTVTYSRVGIELWGSKTIGECTPRQVENVRSKRRVV 323
            .|      ......::......|.||:..:::.|.|....||.:  :|   |.......::||..
  Rat   177 ED------ARRRALDVATFAAGYLLPVAVVSLAYGRTLCFLWAA--VG---PAGAAAAEARRRAT 230

  Fly   324 ----KMMIVVVLIFAICWLPFHSYFIITSCYPAITEAPFIQELYLAIYWLAMSNSMYNPIIYCWM 384
                :.|:.|..::|:||.|.|: .|:...|.....:|......||.:.||.:||..||::|...
  Rat   231 GRAGRAMLAVAALYALCWGPHHA-LILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYSLA 294

  Fly   385 NSRFRYGFKMVFRWCLFVRVGTEPFSRRENLTSRYSCSGSPDHNRIKRNDTQKSILYTCPSSPKS 449
            :..||..|:.:  |         |..||.:   |:       |:|                   :
  Rat   295 SRHFRARFRRL--W---------PCGRRRH---RH-------HHR-------------------A 319

  Fly   450 HRISHSGTGRSATLRNSLPAESLSSGGSGGGGHRKRLSYQQE 491
            ||          .||...||   |||.:|..|..:...:..|
  Rat   320 HR----------ALRRVQPA---SSGPAGYPGDARPRGWSME 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR99D	NP_001263092.1	7tmA_TACR	102..392	CDD:320512	89/302 (29%)
		TM helix 1	103..129	CDD:320512	7/31 (23%)
		TM helix 2	136..162	CDD:320512	9/26 (35%)
		TM helix 3	174..204	CDD:320512	14/29 (48%)
		TM helix 4	215..236	CDD:320512	9/22 (41%)
		TM helix 5	269..298	CDD:320512	5/28 (18%)
		TM helix 6	317..347	CDD:320512	10/33 (30%)
		TM helix 7	360..385	CDD:320512	9/24 (38%)
Galr3	NP_062046.1	7tm_GPCRs	18..302	CDD:475119	91/310 (29%)
		TM helix 1	20..44	CDD:410628	10/32 (31%)
		TM helix 2	58..80	CDD:410628	8/21 (38%)
		TM helix 3	96..118	CDD:410628	8/21 (38%)
		TM helix 4	141..157	CDD:410628	7/15 (47%)
		TM helix 5	182..205	CDD:410628	3/22 (14%)
		TM helix 6	234..256	CDD:410628	7/22 (32%)
		TM helix 7	270..295	CDD:410628	9/24 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	317..370		13/64 (20%)