Protein Alignment TkR99D and NPBWR1

DIOPT Version :10

• Sequence 1: NP_001263092.1
• Gene: TkR99D / 43551
• FlyBaseID: FBgn0004622
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_005276.2
• Gene: NPBWR1 / 2831
• HGNCID: 4522
• Length: 328
• Species: Homo sapiens
• Alignment Length: 365
• Identity: 92/365 - (25%)
• Similarity: 166/365 - (45%)
• Gaps: 56/365 - (15%)

  Fly    39 SASNHTPLPDFGQELALSTSSFNHSQTLSTDLPAVGDVEDAAEDAAASMETGSFAFVVPWWRQVL 103
            |.|...|....|.:.|||.|   ::.||: .|||                  ..|..||
Human     5 SFSEPWPANASGPDPALSCS---NASTLA-PLPA------------------PLAVAVP------ 41

  Fly   104 WSILFGGMVIVATGGNLIVVWIVMTTKRMRTVTNYFIVNLSIADAMVSSLNVTFNYYYMLDSDWP 168
              :::..:..|...||..|:::::...||:||||.||:||:|||.:. :|.:..|....|...||
Human    42 --VVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELF-TLVLPINIADFLLRQWP 103

  Fly   169 FGEFYCKLSQFIAMLSICASVFTLMAISIDRYVAIIRPLQP-RMSKRCNLAIAAV---IWLASTL 229
            |||..|||...|...:..:|::.|..:|.|||:.::...:. |::.|...|..||   :|...||
Human   104 FGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTL 168

  Fly   230 ISCPMMIIYRTEEVPVRGLSNRTVCYPEWPDGPTNHSTMESLYNILIIILTYFLPIVSMTVTYSR 294
            :..|..:..|.::.     ..|..|...:|...........||.   ::|.:.:|:.::.|.|:.
Human   169 VVLPFAVFARLDDE-----QGRRQCVLVFPQPEAFWWRASRLYT---LVLGFAIPVSTICVLYTT 225

  Fly   295 VGIELWGSKTIGECTPRQVENVRSKRRVVKMMIVVVLIFAICWLPFHSYFIITSCYPAIT----E 355
            :...|...:.  :...:.:|  |:|:||..:::.::.:..:||.|:|...::     |:|    :
Human   226 LLCRLHAMRL--DSHAKALE--RAKKRVTFLVVAILAVCLLCWTPYHLSTVV-----ALTTDLPQ 281

  Fly   356 APFIQELYLAIYWLAMSNSMYNPIIYCWMNSRFRYGFKMV 395
            .|.:..:...|..|:.:||..||.:|.::::.||...:.:
Human   282 TPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQL 321

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR99D	NP_001263092.1	7tmA_TACR	102..392	CDD:320512	76/297 (26%)
		TM helix 1	103..129	CDD:320512	4/25 (16%)
		TM helix 2	136..162	CDD:320512	11/25 (44%)
		TM helix 3	174..204	CDD:320512	10/29 (34%)
		TM helix 4	215..236	CDD:320512	7/23 (30%)
		TM helix 5	269..298	CDD:320512	6/28 (21%)
		TM helix 6	317..347	CDD:320512	8/29 (28%)
		TM helix 7	360..385	CDD:320512	7/24 (29%)
NPBWR1	NP_005276.2	7tmA_NPBWR	47..318	CDD:320215	76/288 (26%)
		TM helix 2	72..98	CDD:320215	11/26 (42%)
		TM helix 3	109..139	CDD:320215	10/29 (34%)
		TM helix 4	153..175	CDD:320215	7/21 (33%)
		TM helix 5	200..229	CDD:320215	6/31 (19%)
		TM helix 6	244..274	CDD:320215	8/34 (24%)
		TM helix 7	286..311	CDD:320215	7/24 (29%)