Protein Alignment TkR99D and GALR1

DIOPT Version :10

• Sequence 1: NP_001263092.1
• Gene: TkR99D / 43551
• FlyBaseID: FBgn0004622
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_001471.2
• Gene: GALR1 / 2587
• HGNCID: 4132
• Length: 349
• Species: Homo sapiens
• Alignment Length: 309
• Identity: 93/309 - (30%)
• Similarity: 154/309 - (49%)
• Gaps: 44/309 - (14%)

  Fly   106 ILFGGMVIVATGGNLIVVWIVMTTK--RMRTVTNYFIVNLSIADAMVSSLNVTFNYYYMLDSDWP 168
            ::||.:..:...||.:|:.::..:|  :.|:.||.||:||||||.......:.|.........|.
Human    38 VVFGLIFALGVLGNSLVITVLARSKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWV 102

  Fly   169 FGEFYCKLSQFIAMLSICASVFTLMAISIDRYVAII---RPLQPRMSKRCNLAIAAVIWLASTLI 230
            .|.|.||...:...:|:..|:|||.|:|:||||||:   |....|:|:...|.:.. ||..|..:
Human   103 LGAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGC-IWALSIAM 166

  Fly   231 SCPMMIIYRTEEVPVRGL-----SNRTVCYPEWPDGPTNHSTMESLYNILIIILTYFLPIVSMTV 290
            :.|  :.|.      :||     ||:|.|:.:|||  ..|   :..|.:...:..|.||::.:..
Human   167 ASP--VAYH------QGLFHPRASNQTFCWEQWPD--PRH---KKAYVVCTFVFGYLLPLLLICF 218

  Fly   291 TYSRVGIELWGSKTIGECTPRQVENV-----RSKRRVVKMMIVVVLIFAICWLPFHSYFIIT--S 348
            .|::|...|          .::::|:     .||::..:.::|||::|.|.|||.|...:..  .
Human   219 CYAKVLNHL----------HKKLKNMSKKSEASKKKTAQTVLVVVVVFGISWLPHHIIHLWAEFG 273

  Fly   349 CYPAITEAPFIQELYLAIYWLAMSNSMYNPIIYCWMNSRFRYGFKMVFR 397
            .:| :|.|.|:  ..:..:.||.|||..|||||.:::..||..:|.||:
Human   274 VFP-LTPASFL--FRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFK 319

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR99D	NP_001263092.1	7tmA_TACR	102..392	CDD:320512	90/302 (30%)
		TM helix 1	103..129	CDD:320512	5/22 (23%)
		TM helix 2	136..162	CDD:320512	11/25 (44%)
		TM helix 3	174..204	CDD:320512	14/29 (48%)
		TM helix 4	215..236	CDD:320512	5/20 (25%)
		TM helix 5	269..298	CDD:320512	6/28 (21%)
		TM helix 6	317..347	CDD:320512	11/29 (38%)
		TM helix 7	360..385	CDD:320512	10/24 (42%)
GALR1	NP_001471.2	7tmA_Gal1_R	34..314	CDD:320226	90/302 (30%)
		TM helix 1	35..61	CDD:320226	5/22 (23%)
		TM helix 2	70..96	CDD:320226	11/25 (44%)
		TM helix 3	108..138	CDD:320226	14/29 (48%)
		TM helix 4	150..170	CDD:320226	5/22 (23%)
		TM helix 5	197..226	CDD:320226	6/28 (21%)
		TM helix 6	240..270	CDD:320226	11/29 (38%)
		TM helix 7	282..307	CDD:320226	11/26 (42%)