Protein Alignment TkR99D and Qrfpr

DIOPT Version :10

• Sequence 1: NP_001263092.1
• Gene: TkR99D / 43551
• FlyBaseID: FBgn0004622
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_937835.1
• Gene: Qrfpr / 229214
• MGIID: 2677633
• Length: 433
• Species: Mus musculus
• Alignment Length: 490
• Identity: 123/490 - (25%)
• Similarity: 201/490 - (41%)
• Gaps: 112/490 - (22%)

  Fly    35 SSVLSASNHTPLPDFGQELALSTSSFNHSQTL-----STDLPAVGDVEDAAEDAAASMETGSFAF 94
            |.:|||.|            |:...|.|...|     :.:|||
Mouse    12 SRLLSAHN------------LTREQFIHRYGLRPLVYTPELPA---------------------- 42

  Fly    95 VVPWWRQVLWSILFGGMVI-VATGGNLIVVWIVMTTKRMRTVTNYFIVNLSIADAMVSSLNVTFN 158
                 |..|...|.|.::. :|..||.:|:::|..:|.||||||.||.:|:::|.:::...:...
Mouse    43 -----RAKLAFALAGALIFALALFGNSLVIYVVTRSKAMRTVTNIFICSLALSDLLIAFFCIPVT 102

  Fly   159 YYYMLDSDWPFGEFYCKLSQFIAMLSICASVFTLMAISIDRYVAIIRPLQPR--MSKRCNLAIAA 221
            ....:...|..|.|.||:..|:...::...:.|:..|:::|:..:|.|.:.:  .:.|....|..
Mouse   103 MLQNISDKWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLIHPFKMKWQYTTRRAFTILG 167

  Fly   222 VIWLASTLISCPMM----------IIYRTEEVPVRGLSNRTVCYPEWPDGPTNHSTMESLYNILI 276
            |:|||:.::..||.          .:|..|.|         .|..||. .|.:    :.:|...|
Mouse   168 VVWLAAIIVGSPMWHVQRLEIKYDFLYEKEHV---------CCLEEWA-SPMH----QRIYTTFI 218

  Fly   277 IILTYFLPIVSMTVTYSRVGIELWGSKTIGECTPRQV-------ENVRSKRRVVKMMIVVVLIFA 334
            :::.:.||:|.|.|.||::|.|||..|.:|:.:..|.       :..|.|:|.|.||:.||.:||
Mouse   219 LVILFLLPLVVMLVLYSKIGYELWIKKRVGDSSALQTIHGKEMSKIARKKKRAVVMMVTVVALFA 283

  Fly   335 ICWLPFH------SYFIITSCYPAITEAPFIQELYLAIYWLAMSNSMYNPIIYCWMNSRFRYGFK 393
            .||.|||      .|......|..:|    |:.::.....:...||:.||.:|.:||..|:..|.
Mouse   284 ACWAPFHVVHMMVEYSNFEKEYDDVT----IKMVFAVAQTIGFFNSICNPFVYAFMNENFKKNFL 344

  Fly   394 MVFRWCLFVRVGTEPFSRRENLTSRYSCSG-SPDHNRIKRNDTQKSILYTCPSSPKSHRISHSGT 457
            ....:|: ||....|..:..|       || |....|.|.:.:|:.:     :..|....|.:..
Mouse   345 SAVCYCI-VRETFSPGQKPGN-------SGISMMQKRAKLSRSQRPV-----AEAKGDLFSDANV 396

  Fly   458 --------GRSATLRNSLP--AESLSSGGSGGGGH 482
                    |....|:..|.  :..||...:.|.||
Mouse   397 DVKLCEQPGEKRQLKRQLAFFSSELSENSTFGSGH 431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR99D	NP_001263092.1	7tmA_TACR	102..392	CDD:320512	88/315 (28%)
		TM helix 1	103..129	CDD:320512	8/26 (31%)
		TM helix 2	136..162	CDD:320512	6/25 (24%)
		TM helix 3	174..204	CDD:320512	6/29 (21%)
		TM helix 4	215..236	CDD:320512	7/30 (23%)
		TM helix 5	269..298	CDD:320512	10/28 (36%)
		TM helix 6	317..347	CDD:320512	16/35 (46%)
		TM helix 7	360..385	CDD:320512	5/24 (21%)
Qrfpr	NP_937835.1	7tmA_QRFPR	46..343	CDD:320333	88/314 (28%)
		TM helix 1	47..73	CDD:320333	7/25 (28%)
		TM helix 2	80..106	CDD:320333	6/25 (24%)
		TM helix 3	118..148	CDD:320333	6/29 (21%)
		TM helix 4	161..182	CDD:320333	7/20 (35%)
		TM helix 5	211..236	CDD:320333	8/24 (33%)
		TM helix 6	266..296	CDD:320333	15/29 (52%)
		TM helix 7	311..336	CDD:320333	5/24 (21%)