DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TkR99D and Tacr3

DIOPT Version :9

Sequence 1:	NP_001263092.1	Gene:	TkR99D / 43551	FlyBaseID:	FBgn0004622	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_067357.1	Gene:	Tacr3 / 21338	MGIID:	892968	Length:	452	Species:	Mus musculus

Alignment Length:	470	Identity:	178/470 - (37%)
Similarity:	275/470 - (58%)	Gaps:	52/470 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 NWSNWSTPAGVLFSAMSSVLSASNHTPLPDFGQELALSTSSFNHSQTLSTDLPAVGDVEDAAEDA 83
            ||::.:...|.....:|:.|..:         :.|||...:|:.    :..||.   ...|....
Mouse     9 NWTDGTAGVGSHTGNLSAALGIT---------EWLALQAGNFSS----ALGLPV---TSQAPSQV 57

  Fly    84 AASMETGSFAFVVPWWRQVLWSILFGGMVIVATGGNLIVVWIVMTTKRMRTVTNYFIVNLSIADA 148
            .|::..   .||.|.||..|||:.:|.:|.||..|||||:||::..||||||||||:|||:.:||
Mouse    58 RANLTN---QFVQPSWRIALWSLAYGLVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDA 119

  Fly   149 MVSSLNVTFNYYYMLDSDWPFGEFYCKLSQFIAMLSICASVFTLMAISIDRYVAIIRPLQPRMSK 213
            .|::.|...|:.|.:.|:|.||..||:...|..:.::.||::::.||::|||:|||.||:||:|.
Mouse   120 SVAAFNTLVNFIYGVHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSA 184

  Fly   214 RCNLAIAAVIWLASTLISCPMMIIYRTEEVPVRGLSNRTVCYPEWPDGPTNHSTMESLYNILIII 278
            .....:...||:.:.|::.|..:..:.:.:|     .||:||.:||:||..|.|    |:|::||
Mouse   185 TATKIVIGSIWILAFLLAFPQCLYSKIKVMP-----GRTLCYVQWPEGPKQHFT----YHIIVII 240

  Fly   279 LTYFLPIVSMTVTYSRVGIELWGSKTIGECTPRQVENVRSKRRVVKMMIVVVLIFAICWLPFHSY 343
            |.|..|::.|.|||:.|||.|||.:..|:...:..|.:::||:||||||:||:.|||||||:|.|
Mouse   241 LVYCFPLLIMGVTYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVVTFAICWLPYHVY 305

  Fly   344 FIITSCYPAITEAPFIQELYLAIYWLAMSNSMYNPIIYCWMNSRFRYGFKMVFRWCLFVRVGTEP 408
            ||:|:.|..:....:||::|||.:|||||::||||||||.:|.|||.|||..||||.|::|.:
Mouse   306 FILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIQVSS-- 368

  Fly   409 FSRRENLTSRYSCSGSPDHNRIKRNDTQKSILYTCPSSPKSHRI----SHSGTGRSATLRNSLPA 469
            :...|..|:|:             :.|::|.|||. |..:|..:    |.....:|:..:.::|.
Mouse   369 YDELELKTTRF-------------HPTRQSSLYTV-SRMESVTVLYDPSEGDPAKSSRKKRAVPR 419

  Fly   470 ESLSSGGSGGGGHRK 484
            :..::|.|    ||:
Mouse   420 DPSANGCS----HRE 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TkR99D	NP_001263092.1	7tm_4	113..396	CDD:304433	132/282 (47%)
TkR99D	NP_001263092.1	7tm_1	118..381	CDD:278431	120/262 (46%)
Tacr3	NP_067357.1	7tm_4	81..>204	CDD:304433	54/122 (44%)
		7tm_1	89..343	CDD:278431	120/262 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	401..452		7/34 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	267	1.000	Domainoid score	I1851
eggNOG	1	0.900	-	-		E1_KOG4219
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H824
Inparanoid	1	1.050	326	1.000	Inparanoid score	I2455
Isobase	1	0.950	-	0	Normalized mean entropy	S4763
OMA	1	1.010	-	-		QHG45276
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000620
OrthoInspector	1	1.000	-	-		mtm8831
orthoMCL	1	0.900	-	-		OOG6_105137
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3520
SonicParanoid	1	1.000	-	-		X257
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.710