DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TkR99D and Tacr2

DIOPT Version :9

Sequence 1:	NP_001263092.1	Gene:	TkR99D / 43551	FlyBaseID:	FBgn0004622	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_033340.3	Gene:	Tacr2 / 21337	MGIID:	98477	Length:	384	Species:	Mus musculus

Alignment Length:	381	Identity:	145/381 - (38%)
Similarity:	218/381 - (57%)	Gaps:	34/381 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 TDLPAVGDVEDAAEDAAASMETGSFAFVVPWWRQVLWSILFGGMVIVATGGNLIVVWIVMTTKRM 132
            ||...:..:|..|        ||..||.:|.|:..||:..:..:|:||..||..|:||::..:||
Mouse     8 TDTNILSGLESNA--------TGVTAFSMPGWQLALWATAYLALVLVAVTGNATVIWIILAHERM 64

  Fly   133 RTVTNYFIVNLSIADAMVSSLNVTFNYYYMLDSDWPFGEFYCKLSQFIAMLSICASVFTLMAISI 197
            ||||||||:||::||..:::.|.|||:.|...:.|.||..:|.......:.::..|::::.||:.
Mouse    65 RTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIYSMTAIAA 129

  Fly   198 DRYVAIIRPLQPRMSKRCNLAIAAVIWLASTLISCPMMIIYRTEEVPVRGLSNRTVCYPEWPDGP 262
            |||:||:.|.|||:|.....|:.|||||.:..::.| ...|.|..|.    ...|.|...||:
Mouse   130 DRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASP-QCFYSTITVD----QGATKCVVAWPN-- 187

  Fly   263 TNHSTMESLYNILIIILTYFLPIVSMTVTYSRVGIELWGSKTIGECTPR------QVENVRSKRR 321
            .|...|..||::::.:|.||||:|.|...||.:|:.||     ....||      .:.::::|::
Mouse   188 DNGGKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLW-----KRAVPRHQAHGANLRHLQAKKK 247

  Fly   322 VVKMMIVVVLIFAICWLPFHSYFIITSCYPAITEAPFIQELYLAIYWLAMSNSMYNPIIYCWMNS 386
            .||.|::||:.|||||||:|.|||:.:....|....|||::|||::|||||::||||||||.:|.
Mouse   248 FVKAMVLVVVTFAICWLPYHLYFILGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNH 312

  Fly   387 RFRYGFKMVFRWCLFVRVGTEPFSRRENLTSRYSCSGSPDHNRIKRNDTQKSILYT 442
            |||.||::.||.|.:   ||.....|..||...|.|     .|:.|..|::::..|
Mouse   313 RFRSGFRLAFRCCPW---GTPTEEDRLELTHTPSIS-----RRVNRCHTKETLFMT 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TkR99D	NP_001263092.1	7tm_4	113..396	CDD:304433	118/288 (41%)
TkR99D	NP_001263092.1	7tm_1	118..381	CDD:278431	107/268 (40%)
Tacr2	NP_033340.3	7tm_4	42..>168	CDD:304433	51/126 (40%)
		7tm_1	50..307	CDD:278431	107/268 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..384
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837173
Domainoid	1	1.000	267	1.000	Domainoid score	I1851
eggNOG	1	0.900	-	-		E1_KOG4219
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	326	1.000	Inparanoid score	I2455
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45276
OrthoDB	1	1.010	-	-		D314830at33208
OrthoFinder	1	1.000	-	-		FOG0000620
OrthoInspector	1	1.000	-	-		mtm8831
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3520
SonicParanoid	1	1.000	-	-		X257
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.800