DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TkR99D and Tacr1

DIOPT Version :9

Sequence 1:	NP_001263092.1	Gene:	TkR99D / 43551	FlyBaseID:	FBgn0004622	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_033339.2	Gene:	Tacr1 / 21336	MGIID:	98475	Length:	407	Species:	Mus musculus

Alignment Length:	376	Identity:	153/376 - (40%)
Similarity:	231/376 - (61%)	Gaps:	19/376 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 FVVPWWRQVLWSILFGGMVIVATGGNLIVVWIVMTTKRMRTVTNYFIVNLSIADAMVSSLNVTFN 158
            ||.|.|:.|||:..:..:|:.:..||::|:||::..||||||||||:|||:.|:|.:::.|...|
Mouse    25 FVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVN 89

  Fly   159 YYYMLDSDWPFGEFYCKLSQFIAMLSICASVFTLMAISIDRYVAIIRPLQPRMSKRCNLAIAAVI 223
            :.|.:.:.|.:|.||||...|..:.::.||::::.|::.|||:|||.|||||:|......:..||
Mouse    90 FTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVI 154

  Fly   224 WLASTLISCPMMIIYRTEEVPVRGLSNRTVCYPEWPDGPTNHSTMESLYNILIIILTYFLPIVSM 288
            |:.:.|::.|......||.:|     :|.||..|||:.|  :.|.|..|:|.:.:|.||||::.:
Mouse   155 WVLALLLAFPQGYYSTTETMP-----SRVVCMIEWPEHP--NRTYEKAYHICVTVLIYFLPLLVI 212

  Fly   289 TVTYSRVGIELWGSKTIGECTPRQVENVRSKRRVVKMMIVVVLIFAICWLPFHSYFIITSCYPAI 353
            ...|:.|||.||.|:..|:.:.|..|.|.:||:|||||||||..|||||||||.:|::....|.:
Mouse   213 GYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDL 277

  Fly   354 TEAPFIQELYLAIYWLAMSNSMYNPIIYCWMNSRFRYGFKMVFRWCLFVRVGTEPFSRRENLTSR 418
            ....|||::|||..|||||::||||||||.:|.|||.|||..||.|.|:..|  .:...|..::|
Mouse   278 YLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAG--DYEGLEMKSTR 340

  Fly   419 YSCSGSPDHNRIKRNDTQKSILYTC---------PSSPKSHRISHSGTGRS 460
            |..:.|..: ::.|.:|..|.:...         .::|.|..::.:|:.||
Mouse   341 YLQTQSSVY-KVSRLETTISTVVGAHEDEPEEGPKATPSSLDLTSNGSSRS 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TkR99D	NP_001263092.1	7tm_4	113..396	CDD:304433	128/282 (45%)
TkR99D	NP_001263092.1	7tm_1	118..381	CDD:278431	118/262 (45%)
Tacr1	NP_033339.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		7tm_GPCRs	33..316	CDD:391938	129/289 (45%)
		TM helix 1	35..59	CDD:341315	7/23 (30%)
		TM helix 2	68..90	CDD:341315	9/21 (43%)
		TM helix 3	106..128	CDD:341315	5/21 (24%)
		TM helix 4	149..165	CDD:341315	4/15 (27%)
		TM helix 5	194..217	CDD:341315	7/22 (32%)
		TM helix 6	244..269	CDD:341315	19/24 (79%)
		TM helix 7	284..309	CDD:341315	17/24 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..407		5/29 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	267	1.000	Domainoid score	I1851
eggNOG	1	0.900	-	-		E1_KOG4219
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	326	1.000	Inparanoid score	I2455
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45276
OrthoDB	1	1.010	-	-		D314830at33208
OrthoFinder	1	1.000	-	-		FOG0000620
OrthoInspector	1	1.000	-	-		mtm8831
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3520
SonicParanoid	1	1.000	-	-		X257
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.870