Protein Alignment TkR99D and tkr-1

DIOPT Version :10

• Sequence 1: NP_001263092.1
• Gene: TkR99D / 43551
• FlyBaseID: FBgn0004622
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_499064.2
• Gene: tkr-1 / 192055
• WormBaseID: WBGene00006576
• Length: 406
• Species: Caenorhabditis elegans
• Alignment Length: 339
• Identity: 112/339 - (33%)
• Similarity: 176/339 - (51%)
• Gaps: 43/339 - (12%)

  Fly    80 AEDAAASMETGSFAFVVPWWR-----QVLWSILFGGMVIVATGGNLIVVWIVMTTKRMRTVTNYF 139
            ||:.....|.....|..|..|     ||..:|.|..::..|..||.:|:||:...|.|....|||
 Worm    17 AENLTLPAELEGIFFCAPSSRESLATQVFVAIAFVLLMATAIIGNSVVMWIIYQHKVMHYGFNYF 81

  Fly   140 IVNLSIADAMVSSLNV----TFNYYYMLDSDWPFGEFYCKLSQFIAMLSICASVFTLMAISIDRY 200
            :.|::.||.:::..||    |:|.||    ||.:|:. |.|:.|..:.....||.::||:|.||.
 Worm    82 LFNMAFADLLIALFNVGTSWTYNLYY----DWWYGDL-CTLTSFFGIAPTTVSVCSMMALSWDRC 141

  Fly   201 VAIIRPLQPR-MSKRCNLAIAAVIWLASTLISCPMMI------IYRTEEVPVRGLSNRTVCYPEW 258
            .|::.|||.| :|::.::....:||:.||:.:.|..|      :| |.:|....:|...||
 Worm   142 QAVVNPLQKRPLSRKRSVIAILIIWVVSTVTALPFAIAASVNSLY-TYDVVTSTVSKAHVC---- 201

  Fly   259 PDGPTNHSTMESLYNILIIILTYFLPIVSMTVTYSRVGIELWGSKTIGECTPRQVEN--VRSKRR 321
             ..|.|     :.:..::..:.|.|||:.:..|::|:.:..   :...|.|...::|  .|:|.:
 Worm   202 -SAPVN-----TFFEKVLFGIQYALPIIILGSTFTRIAVAF---RATNEATDSSLKNNHTRAKSK 257

  Fly   322 VVKMMIVVVLIFAICWLPFHSY--FIITSCYPAITEAPFIQELYLAIYWLAMSNSMYNPIIYCWM 384
            .|||:.::|:.|.:||||:|.|  |.:...:.|...    :..||.|||:|||:..|||||||:.
 Worm   258 AVKMLFLMVVAFVVCWLPYHIYHAFALEEFFDAARG----KYAYLLIYWIAMSSCAYNPIIYCFA 318

  Fly   385 NSRFRYGFKMVFRW 398
            |.|||.||:.||||
 Worm   319 NERFRIGFRYVFRW 332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR99D	NP_001263092.1	7tmA_TACR	102..392	CDD:320512	99/304 (33%)
		TM helix 1	103..129	CDD:320512	8/25 (32%)
		TM helix 2	136..162	CDD:320512	11/29 (38%)
		TM helix 3	174..204	CDD:320512	11/29 (38%)
		TM helix 4	215..236	CDD:320512	5/20 (25%)
		TM helix 5	269..298	CDD:320512	6/28 (21%)
		TM helix 6	317..347	CDD:320512	14/31 (45%)
		TM helix 7	360..385	CDD:320512	15/24 (63%)
tkr-1	NP_499064.2	7tm_GPCRs	44..326	CDD:475119	99/304 (33%)
		TM helix 1	46..70	CDD:320512	8/23 (35%)
		TM helix 2	79..101	CDD:320512	8/21 (38%)
		TM helix 3	116..138	CDD:320512	6/21 (29%)
		TM helix 4	160..176	CDD:320512	4/15 (27%)
		TM helix 5	207..230	CDD:320512	5/22 (23%)
		TM helix 6	259..281	CDD:320512	11/21 (52%)
		TM helix 7	294..319	CDD:320512	15/24 (63%)