Protein Alignment TkR99D and npr-32

DIOPT Version :10

• Sequence 1: NP_001263092.1
• Gene: TkR99D / 43551
• FlyBaseID: FBgn0004622
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_503056.4
• Gene: npr-32 / 190990
• WormBaseID: WBGene00013782
• Length: 440
• Species: Caenorhabditis elegans
• Alignment Length: 485
• Identity: 99/485 - (20%)
• Similarity: 188/485 - (38%)
• Gaps: 130/485 - (26%)

  Fly    61 NHSQTLSTDL--PAVGDVEDAAEDAAASMETGSFAFVVPWWRQVLWSILFGGMVIVATGGNLIVV 123
            |.|..:||..  |||.:.:|.:....                :::.:|.:..:.|:.|.||..|:
 Worm     2 NISTIISTTTTPPAVSNEDDTSRTTL----------------KLVLAISYLVLFIIGTVGNGTVI 50

  Fly   124 WIVMTT-----------KRMRTVTNY---FIVNLSIADAMVSSLNVTFNYYYMLDSDWPFGEFYC 174
            .:::..           |||.:.||:   :::.|||.|.:| .|::.|....:|...|.||...|
 Worm    51 LMIINILTSMKRNVQAGKRMMSSTNHVFIYVLGLSIVDLLV-ILHLPFLVVDLLKGQWLFGVAMC 114

  Fly   175 KLSQFIAMLSICASVFTLMAISIDRYVAIIRPLQPRMSKRCNLAIAAVIWLASTLISCPMM--II 237
            |:..|...::...|.|.:..:|.|||:|:..|:: .|..|.| |.|..:.||.|:.:..::  ::
 Worm   115 KVYWFGESVNKLLSSFLMTVLSWDRYMAVCSPVK-SMKMRSN-ATALKVLLACTIFATVLLLPVL 177

  Fly   238 YR-----------------TEEVPVRGLSNRTV--CYPEWPDGPTNHSTMESLYNILIIILTYFL 283
            |.                 |||:....|:..|:  |..:          .::.:.:...::.:..
 Worm   178 YEAAVFKIDKMRMVPLLEGTEELAASDLAGTTMSKCMFD----------ADATFTLYTFVIGFAA 232

  Fly   284 PIVSMTVTYSRVGIELWGSKTIGECTPRQVENVRSKR-------------RVVKMMIVVVLIFAI 335
            |...:.:.|.:|...|..|.          .|:|..|             :|.|.::.|:|.:.:
 Worm   233 PAFLIIIFYVQVIYALQKSS----------RNIRGARGISKPDGSSNRVKKVTKRIVAVILFYFL 287

  Fly   336 CWLPFHSYFIITSCYPAITEA---PFIQELYLAIYWLAMSNSMYNPIIYCWMNSRFRYGFKMVFR 397
            ||.|..:..|: |.:..|..:   |.:..::...:.|...||..||::|.::|...|....|...
 Worm   288 CWTPQWTLNIM-SQFNLIAVSWMTPALSAMFFVAHLLVCFNSAANPVLYAYINRELRSQHVMAMH 351

  Fly   398 WCLFVRVGTEPFSRRENLTSRYSCSGSPDHNRIKRNDTQKSILYTCPSSPKS---HRISHSGTG- 458
                        .:|.:|          .|.:.:|.:..:..:.:.||...:   .::..|..|
 Worm   352 ------------RKRHSL----------GHEQQQRLNQARLSMQSRPSDASATVFSKLGDSDAGI 394

  Fly   459 --RSATLRNSLPAESLSSGGSGGGGHRKRL 486
              |.:..:.::.|..|         ||||:
 Worm   395 FNRLSNFQQNIIASIL---------HRKRI 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR99D	NP_001263092.1	7tmA_TACR	102..392	CDD:320512	75/340 (22%)
		TM helix 1	103..129	CDD:320512	6/25 (24%)
		TM helix 2	136..162	CDD:320512	9/28 (32%)
		TM helix 3	174..204	CDD:320512	10/29 (34%)
		TM helix 4	215..236	CDD:320512	6/22 (27%)
		TM helix 5	269..298	CDD:320512	3/28 (11%)
		TM helix 6	317..347	CDD:320512	10/42 (24%)
		TM helix 7	360..385	CDD:320512	6/24 (25%)
npr-32	NP_503056.4	7tm_classA_rhodopsin-like	31..339	CDD:410626	73/331 (22%)
		TM helix 1	31..63	CDD:410626	6/31 (19%)
		TM helix 2	74..102	CDD:410626	9/28 (32%)
		TM helix 3	114..144	CDD:410626	10/29 (34%)
		TM helix 4	157..176	CDD:410626	4/18 (22%)
		TM helix 5	218..243	CDD:410626	2/24 (8%)
		TM helix 6	269..299	CDD:410626	8/30 (27%)
		TM helix 7	314..339	CDD:410626	6/24 (25%)