DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TkR99D and npr-22

DIOPT Version :9

Sequence 1:	NP_001263092.1	Gene:	TkR99D / 43551	FlyBaseID:	FBgn0004622	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001023541.1	Gene:	npr-22 / 190424	WormBaseID:	WBGene00022004	Length:	434	Species:	Caenorhabditis elegans

Alignment Length:	462	Identity:	135/462 - (29%)
Similarity:	222/462 - (48%)	Gaps:	77/462 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SSVLSASNHTPLPDFGQELALSTSSFNHSQTLSTDLPAVGDVEDAAEDAAASMETGSFAFVVPWW 99
            ||:||....|     ..|:.:      .::..:|:.|||             .|......:.|..
Worm     9 SSLLSRITTT-----ASEIMM------RNEPTTTENPAV-------------QEMNHIYHLTPSM 49

  Fly   100 RQVLWSILFGGMVIV-ATGGNLIVVWIVMTTKRMRTVTNYFIVNLSIADAMVSSLNVTFNYYYML 163
            :.:  .|||..::.| ...||::|:.:::..||:||.||..|:||::||.::|...:.|:|:.:|
Worm    50 KML--CILFYSILCVCCVYGNVLVILVIVYFKRLRTATNILILNLAVADLLISVFCIPFSYWQVL 112

  Fly   164 ---DSDWPFGEFYCKLSQFIAMLSICASVFTLMAISIDRYVAIIRPLQP--RMSKRCNLAIAAVI 223
               |..|.||...|.|..|:..:::..|.:||:.||.||::||:..|.|  |:::|..|.:.|..
Worm   113 IYDDQRWLFGSMMCSLLAFLQAMAVFLSAWTLVVISFDRWMAIMFLLTPNIRITRRRALYLVAAT 177

  Fly   224 WLASTLISCPMMIIYRTEEVPVRGLSNRTVCYPEWPDGPTNHSTMESLYNILIIILTYFLPIVSM 288
            |:.|.|::.|::...|..| ...||.|   |...|.....:...:..:|:.:::||.|.:|...:
Worm   178 WIFSILMALPLLFTTRFFE-DQDGLPN---CGENWTYFGDSGEQVRKVYSSMVLILQYVVPQAVL 238

  Fly   289 TVTYSRVGIELWGSKTIG---ECTPRQ-VENVRSKRRVVKMMIVVVLIFAICWLPFHSYF-IITS 348
            .:||:.:||::|.|:..|   ..|.:. |:...|.:::|.|:|::..:||:||||..... :|..
Worm   239 IITYTHIGIKMWNSRVPGMQNGATKKMIVDRHESVKKLVPMVILISALFALCWLPLLILINVIPE 303

  Fly   349 CYPAITEAPFIQELYLAIYWLAMSNSMYNPIIYCWMNSRFRYGFKMVFRWCLF------------ 401
            .||.|....:|..|:...:.||||:||.|||||...|:|||.||      |.|
Worm   304 FYPDINSWGYILYLWWFAHGLAMSHSMVNPIIYFIRNARFREGF------CFFSSKLLPCISFKE 362

  Fly   402 VRVGTEPFSRRENLTSRYSCSGSPDHNRIKRNDTQKSILYTCPSSPKSHRISHSG-----TGRSA 461
            :|:.|:..||.....||:|...:|..:..|            |::..: |.|.||     |.|||
Worm   363 LRLLTDNTSRSFRNRSRFSGVINPTSSDEK------------PATSLT-RYSRSGVLDRQTCRSA 414

  Fly   462 TLRNSLP 468
            ....:.|
Worm   415 RFFEARP 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TkR99D	NP_001263092.1	7tm_4	113..396	CDD:304433	99/293 (34%)
TkR99D	NP_001263092.1	7tm_1	118..381	CDD:278431	90/272 (33%)
npr-22	NP_001023541.1	7tmA_PR4-like	51..347	CDD:320514	100/301 (33%)
		TM helix 1	52..78	CDD:320514	7/27 (26%)
		TM helix 2	85..110	CDD:320514	10/24 (42%)
		TM helix 3	126..156	CDD:320514	11/29 (38%)
		TM helix 4	169..190	CDD:320514	6/20 (30%)
		TM helix 5	219..248	CDD:320514	8/28 (29%)
		TM helix 6	271..301	CDD:320514	10/29 (34%)
		TM helix 7	315..340	CDD:320514	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314830at33208
OrthoFinder	1	1.000	-	-		FOG0000620
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920