Protein Alignment TkR99D and npr-34

DIOPT Version :10

• Sequence 1: NP_001263092.1
• Gene: TkR99D / 43551
• FlyBaseID: FBgn0004622
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_497057.2
• Gene: npr-34 / 175131
• WormBaseID: WBGene00013187
• Length: 613
• Species: Caenorhabditis elegans
• Alignment Length: 675
• Identity: 142/675 - (21%)
• Similarity: 243/675 - (36%)
• Gaps: 196/675 - (29%)

  Fly     2 ENRSDFEADDYGDISWSNWSNWSTPAGVLFSAMSSVLSASNHTPLPDFGQELALSTSSFNHSQTL 66
            |...|:|.|:..|     |||        .:||....:...|..|     |:.:|..:
 Worm    15 ETTFDYEYDETFD-----WSN--------MTAMDCNCTHPLHKYL-----EVCISRCT------- 54

  Fly    67 STDLPAVGDVEDAAEDAAASMETGSFAFVVPWWRQVLWSILFGGMVIVATGGNLIVVWIVMTTKR 131
                        ..:|......|....|.:     .|...|:..:.:|.|.||.:|:::|...||
 Worm    55 ------------VPDDTVFFSMTDEELFEI-----ALPGFLYLTVFLVGTIGNSMVIFVVNRFKR 102

  Fly   132 MRTVTNYFIVNLSIADAMVSSLNVTFNYYYMLDSDWPFGEFYCKLSQFIAMLSICASVFTLMAIS 196
            ||.|||.|:.:||.||..:....|...:...:...|..|.|.|....:|...:...||.|:..||
 Worm   103 MRNVTNIFLASLSTADLCLIWFCVPIMFMKYMSHTWSMGRFACYSVHYIQQFTCFCSVLTMTMIS 167

  Fly   197 IDRYVAIIRPLQ-------PRMSKRCNLAIAAVIWLASTLISCPMMIIYRTEEVPVRGLSNRTV- 253
            .:|::||..|::       .|..|     :..:||::|.:::.|..:  |.:......||.:.|
 Worm   168 FERFLAIAYPMRNIWFSSIGRAKK-----VILLIWMSSAVLAVPTAV--RMDYETNLSLSGQRVH 225

  Fly   254 -C----------YPEWPDGPTNHSTMESLYNILIIILTYFLPIVSMTVTYSRVGIELWGS----- 302
             |          ||.     |:.:...::|.:|::|:   .|:::|::.|:||...::.|
 Worm   226 WCRRRFPAQFLGYPR-----TSLNKAYAMYQLLLLII---FPVLTMSICYARVSAIVYKSSKDRV 282

  Fly   303 ----------------------------------KTIGECTPRQVENVR-------SKRRVVKMM 326
                                              || ...|.:...|.|       :|:::|:|:
 Worm   283 ILSQAMVAFSKAATDAVTFSGYSAIPMITTSRNLKT-ANTTIKSYSNHRNNRVAEANKKQIVQML 346

  Fly   327 IVVVLIFAICWLPFHSYFIITS----CYPAITEAPFIQELYLAIYWLAMSNSMYNPIIYCWMNSR 387
            |.:|.::.:||||.....::||    |..:.|:.  ::.:.:....|....|..|||:|.:::..
 Worm   347 ISIVCMYTVCWLPTIVDELLTSFGYICRTSNTQT--LKHMRMGFNALTYCQSCINPILYAFISQN 409

  Fly   388 FRYGFKMVFRWCLFVRVGTEPFSRRENLTSRYSCSGSPDHNRI--------------------KR 432
            ||..||..:........|.|....|....|..|...:.:.:||                    .|
 Worm   410 FRSTFKTAYSRMKSRLQGVEEMRSRMGSCSSASMMSTRNQHRIYGSSFNTLTVPGRSMITPNMSR 474

  Fly   433 NDTQKSIL-------YTCPSSPKS---------HR------ISH-SGTGRSATLRNSLPAESLSS 474
            :.:|.|:.       :..|.||.:         ||      :|| ||..||.|
 Worm   475 DVSQLSLCRPTSQMSFCRPKSPMAGDSPSTFMRHRPRSPTDVSHDSGRPRSPT------------ 527

  Fly   475 GGSGGGGHRKRLSYQQEMQQRWSG--PNSATAVTNSSSTANTTQLLSXQPAIQVVPPEMQTQIVC 537
                      .||...:..:|.|.  |.|.|:.:..|:...:...........:.|...::..:.
 Worm   528 ----------DLSQSTKPSRRSSSIRPRSPTSTSQMSTIVRSRSPTGASDTSSLFPSRTRSPTLQ 582

  Fly   538 SSPYNNNYRRANPGLSDRDSSDDKT 562
            |:....:..|....||.||:...||
 Worm   583 SNTSGQSMERTTDRLSVRDAVRPKT 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR99D	NP_001263092.1	7tmA_TACR	102..392	CDD:320512	84/358 (23%)
		TM helix 1	103..129	CDD:320512	8/25 (32%)
		TM helix 2	136..162	CDD:320512	8/25 (32%)
		TM helix 3	174..204	CDD:320512	9/29 (31%)
		TM helix 4	215..236	CDD:320512	4/20 (20%)
		TM helix 5	269..298	CDD:320512	8/28 (29%)
		TM helix 6	317..347	CDD:320512	10/36 (28%)
		TM helix 7	360..385	CDD:320512	6/24 (25%)
npr-34	NP_497057.2	7tmA_GPRnna14-like	75..414	CDD:320132	83/356 (23%)
		TM helix 1	75..100	CDD:320132	7/24 (29%)
		TM helix 2	107..132	CDD:320132	8/24 (33%)
		TM helix 3	145..175	CDD:320132	9/29 (31%)
		TM helix 4	188..209	CDD:320132	6/25 (24%)
		TM helix 5	244..269	CDD:320132	6/27 (22%)
		TM helix 6	337..367	CDD:320132	9/29 (31%)
		TM helix 7	382..407	CDD:320132	6/24 (25%)