Protein Alignment TkR99D and Grpr

DIOPT Version :10

• Sequence 1: NP_001263092.1
• Gene: TkR99D / 43551
• FlyBaseID: FBgn0004622
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_032203.1
• Gene: Grpr / 14829
• MGIID: 95836
• Length: 384
• Species: Mus musculus
• Alignment Length: 392
• Identity: 108/392 - (27%)
• Similarity: 175/392 - (44%)
• Gaps: 82/392 - (20%)

  Fly    92 FAFVVPWWRQVLWSILFGGMVIVATGGNLIVVWIVMTTKRMRTVTNYFIVNLSIAD--AMVSSLN 154
            |.:|:|        .::|.::::...||:.::.|..|.|.||.|.|.||.:|::.|  .:|:...
Mouse    40 FIYVIP--------AVYGLIIVIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAP 96

  Fly   155 VTFNYYYMLDSDWPFGEFYCKLSQFIAMLSICASVFTLMAISIDRYVAIIRPLQPRMS----KRC 215
            |..:.|  |...|.||...|||..||.:.|:..|||||.|:|.|||.||:||:..:.|    |.|
Mouse    97 VDASKY--LADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKIC 159

  Fly   216 NLAIAAVIWLASTLISCPMMIIYRTEEVPVRGLSNRTV--CYPEWPDGPTNHSTMESLYNILIII 278
              ..||:||:.|.|::.|..:........|:. :|:|.  |.| :|.....|..:.|:.:.|:.
Mouse   160 --LKAALIWIVSMLLAIPEAVFSDLHPFHVKD-TNQTFISCAP-YPHSNELHPKIHSMASFLVF- 219

  Fly   279 LTYFLPIVSMTVTY---------SRVGIELWGSKTIGECTPRQVENVRSKRRVVKMMIVVVLIFA 334
              |.:|:..::|.|         |...:.:.|:..:    .:|:|   |::|:.|.::|.|.:||
Mouse   220 --YVIPLAIISVYYYFIARNLIQSAYNLPVEGNIHV----KKQIE---SRKRLAKTVLVFVGLFA 275

  Fly   335 ICWLPFHSYFIITSCYPAITEAP---FIQELYLAIYWLAMSNSMYNPIIYCWMNSRFRYGFKMVF 396
            .||||.|..::..|.:.:..:..   |:..:...:  ||.:||..||.....::..||..|....
Mouse   276 FCWLPNHVIYLYRSYHYSEVDTSMLHFVTSICARL--LAFTNSCVNPFALYLLSKSFRKQFNTQL 338

  Fly   397 RWCLFVRVGTEP-FSRRENLTSRYSCSGSPDHNRIKRNDTQKSILYTCPSSPKSHRISHSGTGRS 460
            ..|       :| ...|.:.|.|.:                     ||.:|.||       |..|
Mouse   339 LCC-------QPGLMNRSHSTGRST---------------------TCMTSFKS-------TNPS 368

  Fly   461 AT 462
            ||
Mouse   369 AT 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR99D	NP_001263092.1	7tmA_TACR	102..392	CDD:320512	90/309 (29%)
		TM helix 1	103..129	CDD:320512	4/25 (16%)
		TM helix 2	136..162	CDD:320512	8/27 (30%)
		TM helix 3	174..204	CDD:320512	17/29 (59%)
		TM helix 4	215..236	CDD:320512	8/20 (40%)
		TM helix 5	269..298	CDD:320512	7/37 (19%)
		TM helix 6	317..347	CDD:320512	12/29 (41%)
		TM helix 7	360..385	CDD:320512	6/24 (25%)
Grpr	NP_032203.1	7tmA_GRPR	42..334	CDD:320252	92/317 (29%)
		TM helix 1	43..69	CDD:320252	6/33 (18%)
		TM helix 2	76..102	CDD:320252	7/25 (28%)
		TM helix 3	114..144	CDD:320252	17/29 (59%)
		TM helix 4	156..176	CDD:320252	8/21 (38%)
		TM helix 5	208..233	CDD:320252	6/27 (22%)
		TM helix 6	258..288	CDD:320252	13/32 (41%)
		TM helix 7	302..327	CDD:320252	7/26 (27%)