Protein Alignment TkR99D and Gpr83

DIOPT Version :10

• Sequence 1: NP_001263092.1
• Gene: TkR99D / 43551
• FlyBaseID: FBgn0004622
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: XP_030099918.1
• Gene: Gpr83 / 14608
• MGIID: 95712
• Length: 480
• Species: Mus musculus
• Alignment Length: 524
• Identity: 138/524 - (26%)
• Similarity: 217/524 - (41%)
• Gaps: 135/524 - (25%)

  Fly    26 PAGVLFSAMSSVLSASNHTPLPDF-GQELAL----STSSFNHSQTLSTDLPAVGDVEDAAEDAAA 85
            |..:|...:|||.:......:.:. ..|.||    ::|.|..:.|.|.....||.....||....
Mouse     4 PPVLLLFLLSSVRATEQPQVVTEHPSMEAALTGPNASSHFWANYTFSDWQNFVGRRRYGAESQNP 68

  Fly    86 SMETGSFAFVVPWWRQVLWSILFGGMVIVATGGNLIVVWIVMTTKRMRTVTNYFIVNLSIADAMV 150
            ::             :.|..:.:...::.:..||::|..::...:||.:.|:.|||||::||.|:
Mouse    69 TV-------------KALLIVAYSFTIVFSLFGNVLVCHVIFKNQRMHSATSLFIVNLAVADIMI 120

  Fly   151 SSLNVTFNYYYMLDSDWPFGEFYCKLSQFIAMLSICASVFTLMAISIDRY--------------- 200
            :.||..|.....::|.|.||:..|.:|:|....|:..|..||.||::||:
Mouse   121 TLLNTPFTLVRFVNSTWVFGKGMCHVSRFAQYCSLHVSALTLTAIAVDRHQGLELQKMVRPRGDG 185

  Fly   201 ------------------------------------------VAIIRPLQPRMSKRCNLAIAAVI 223
                                                      ..|:.||:||:|....:...|||
Mouse   186 GELRSPSVTFVPSSLCPALFTCKRPWDFQESQSLHDTLFPPLEVIMHPLKPRISITKGVIYIAVI 250

  Fly   224 WLASTLIS-----CPMMIIYRTEEVPVRGLSNRTVCYPEWPDGPTNHSTMESLYNILIIILTYFL 283
            |:.:|..|     |..:..::..|..||.|     |.|::|: |.:  ......::...||.|.|
Mouse   251 WVMATFFSLPHAICQKLFTFKYSEDIVRSL-----CLPDFPE-PAD--LFWKYLDLATFILLYLL 307

  Fly   284 PIVSMTVTYSRVGIELWGSKTIGECTPRQVENVRSKRR-VVKMMIVVVLIFAICWLPFHSYFIIT 347
            |:..::|.|:||..:||...|||:.|..|...:|.|:: .|||:::||::||:||.|.:.|.::.
Mouse   308 PLFIISVAYARVAKKLWLCNTIGDVTTEQYLALRRKKKTTVKMLVLVVVLFALCWFPLNCYVLLL 372

  Fly   348 SCYPAITEAPFIQELYLAIYWLAMSNSMYNPIIYCWMNSRFRYGFKMVFRWCLFVRVGTEPFSRR 412
            |.....|.    ..||.|.:|.|||::.|||.||||:|..||...|.:...|      ..|
Mouse   373 SSKAIHTN----NALYFAFHWFAMSSTCYNPFIYCWLNENFRVELKALLSMC------QRP---- 423

  Fly   413 ENLTSRYSCSGSPDHNRIKRNDTQKSILYTCPSSPKSHRI-----SHSGTGRSATLRN-SLPAES 471
                      ..|..:|:             ||...|.|:     ||   ||.|.|.| .||:..
Mouse   424 ----------PKPQEDRL-------------PSPVPSFRVAWTEKSH---GRRAPLPNHHLPSSQ 462

  Fly   472 LSSG 475
            :.||
Mouse   463 IQSG 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR99D	NP_001263092.1	7tmA_TACR	102..392	CDD:320512	102/352 (29%)
		TM helix 1	103..129	CDD:320512	4/25 (16%)
		TM helix 2	136..162	CDD:320512	12/25 (48%)
		TM helix 3	174..204	CDD:320512	11/86 (13%)
		TM helix 4	215..236	CDD:320512	7/25 (28%)
		TM helix 5	269..298	CDD:320512	9/28 (32%)
		TM helix 6	317..347	CDD:320512	13/30 (43%)
		TM helix 7	360..385	CDD:320512	14/24 (58%)
Gpr83	XP_030099918.1	7tmA_GPR83	72..413	CDD:320511	102/352 (29%)
		TM helix 1	73..99	CDD:320511	4/25 (16%)
		TM helix 2	106..131	CDD:320511	12/24 (50%)
		TM helix 3	144..231	CDD:320511	11/86 (13%)
		TM helix 4	242..263	CDD:320511	6/20 (30%)
		TM helix 5	293..322	CDD:320511	9/28 (32%)
		TM helix 6	342..372	CDD:320511	12/29 (41%)
		TM helix 7	381..406	CDD:320511	14/24 (58%)