Protein Alignment TkR99D and Cckbr

DIOPT Version :10

• Sequence 1: NP_001263092.1
• Gene: TkR99D / 43551
• FlyBaseID: FBgn0004622
• Length: 564
• Species: Drosophila melanogaster
• Sequence 2: NP_031653.1
• Gene: Cckbr / 12426
• MGIID: 99479
• Length: 453
• Species: Mus musculus
• Alignment Length: 435
• Identity: 103/435 - (23%)
• Similarity: 187/435 - (42%)
• Gaps: 119/435 - (27%)

  Fly    38 LSASNHTPLPDFGQELA------LSTSSFNHSQTLSTDLPAVGDVEDAAEDAAASMETGSFAFVV 96
            |:.|...|.|..|..|.      |::||   :..||.:.|.:           ....|......:
Mouse     6 LNRSLQGPGPGSGSSLCRPGVSLLNSSS---AGNLSCETPRI-----------RGTGTRELELTI 56

  Fly    97 PWWRQVLWSILFGGMVIVATGGNLIVVWIVMTTKRMRTVTNYFIVNLSIADAMVSSLNVTFNYYY 161
               |..|::::|    :::.|||::::.::..::|:|||||.|:::|:::|.:::...:.|....
Mouse    57 ---RITLYAVIF----LMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLP 114

  Fly   162 MLDSDWPFGEFYCKLSQFIAMLSICASVFTLMAISIDRYVAIIRPLQPRMSKRCNLAIAAVI--W 224
            .|...:.||...||...::..:|:..|...|.||:::||.||.||||.|:.:..:.|...::  |
Mouse   115 NLMGTFIFGTVICKAVSYLMGVSVSVSTLNLAAIALERYSAICRPLQARVWQTRSHAARVILATW 179

  Fly   225 LASTLISCPMMIIYRTEEVPVRGLSNRTVCYPEWPDGPTNHSTMESLYNILIIILTYFLPIVSMT 289
            |.|.|:..|..:....:.|..|.|.    |...||.     ..::.::::|::||.:|:|.|.|.
Mouse   180 LLSGLLMVPYPVYTVVQPVGPRILQ----CMHLWPS-----ERVQQMWSVLLLILLFFIPGVVMA 235

  Fly   290 VTYSRVGIELW-------------------------------------GSKTIGECT-------- 309
            |.|..:..||:                                     |.:.:...|
Mouse   236 VAYGLISRELYLGLRFDGDNDSETQSRVRNQGGLPGGAAAPGPVHQNGGCRHVTSLTGEDSDGCY 300

  Fly   310 -------------------------PRQVENVRSKRRVVKMMIVVVLIFAICWLPFHS-----YF 344
                                     |.|.: :.:|:|||:|::|:||:|.:||||.:|     .|
Mouse   301 VQLPRSRLEMTTLTTPTTGPGPGPRPNQAK-LLAKKRVVRMLLVIVLLFFVCWLPVYSANTWRAF 364

  Fly   345 IITSCYPAITEAPFIQELYLAIYWLAMSNSMYNPIIYCWMNSRFR 389
            .......|:..||.     ..|:.|:.:::..||::||:|:.|||
Mouse   365 DGPGARRALAGAPI-----SFIHLLSYTSACANPLVYCFMHRRFR 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TkR99D	NP_001263092.1	7tmA_TACR	102..392	CDD:320512	89/365 (24%)
		TM helix 1	103..129	CDD:320512	5/25 (20%)
		TM helix 2	136..162	CDD:320512	6/25 (24%)
		TM helix 3	174..204	CDD:320512	10/29 (34%)
		TM helix 4	215..236	CDD:320512	6/22 (27%)
		TM helix 5	269..298	CDD:320512	9/28 (32%)
		TM helix 6	317..347	CDD:320512	15/34 (44%)
		TM helix 7	360..385	CDD:320512	6/24 (25%)
Cckbr	NP_031653.1	7tm_GPCRs	55..407	CDD:475119	90/372 (24%)
		TM helix 1	57..81	CDD:320645	6/27 (22%)
		TM helix 2	90..112	CDD:320645	5/21 (24%)
		TM helix 3	128..150	CDD:320645	6/21 (29%)
		TM helix 4	173..189	CDD:320645	4/15 (27%)
		TM helix 5	216..239	CDD:320645	8/22 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..276		0/18 (0%)
		TM helix 6	338..360	CDD:320645	11/21 (52%)
		TM helix 7	375..400	CDD:320645	8/29 (28%)