DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TkR99D and tacr1

DIOPT Version :9

Sequence 1:	NP_001263092.1	Gene:	TkR99D / 43551	FlyBaseID:	FBgn0004622	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001106489.1	Gene:	tacr1 / 100127678	XenbaseID:	XB-GENE-5835469	Length:	407	Species:	Xenopus tropicalis

Alignment Length:	452	Identity:	166/452 - (36%)
Similarity:	246/452 - (54%)	Gaps:	72/452 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 FVVPWWRQVLWSILFGGMVIVATGGNLIVVWIVMTTKRMRTVTNYFIVNLSIADAMVSSLNVTFN 158
            |:.|.|:..||||.:..:|||:..||:||:||::..||||||||||:|||:.|:|.:|:.|...|
Frog    25 FLQPAWQIALWSIAYSIIVIVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVIN 89

  Fly   159 YYYMLDSDWPFGEFYCKLSQFIAMLSICASVFTLMAISIDRYVAIIRPLQPRMSKRCNLAIAAVI 223
            :.|.:.:.|.:|..|||...|..:.::.:|::::.||::|||:|||.||:||:|......:.|||
Frog    90 FTYAIHNHWYYGLIYCKFHNFFPISAVFSSIYSMTAIALDRYMAIIHPLKPRLSATATRIVIAVI 154

  Fly   224 WLASTLISCPMMIIYRTEEVPVRGLSNRTVCYPEWPDGPTNHSTMESLYNILIIILTYFLPIVSM 288
            |..:..::.|.......|..|     :|.|||.|||:  :.:...|.:|.:|:..|.||||::.:
Frog   155 WGFAFALAFPQGYFATVEPTP-----DRVVCYMEWPE--SENRKFEKVYQVLLFGLIYFLPLLVI 212

  Fly   289 TVTYSRVGIELWGSKTIGECTPRQVENVRSKRRVVKMMIVVVLIFAICWLPFHSYFIITSCYPAI 353
            ..:|:.:|:.||.|:..|:.:.|..|.|.:||:|||||||||..|||||||:|.||::....|..
Frog   213 GCSYTFIGMTLWASEIPGDSSDRYHEQVVAKRKVVKMMIVVVCTFAICWLPYHIYFLLQLFLPDE 277

  Fly   354 TEAPFIQELYLAIYWLAMSNSMYNPIIYCWMNSRFRYGFKMVFRWCLFVRVGTEPFSRRENLTSR 418
            :: .|.|:|||.|.||.||::||||||||.:|.|||.|||.|||||.|:..|  .:...|..::|
Frog   278 SQ-KFYQQLYLGIMWLGMSSTMYNPIIYCCLNDRFRIGFKHVFRWCPFIHAG--EYEGLEMKSTR 339

  Fly   419 YSCSGSPDHNRIKRNDTQKSILYTCPSSPKSHRISHSGTGRSATL-RNSLPAESLSSGGSGGGGH 482
            |.             .||.|:          ::||...|..|:.| .|...||..:...
Frog   340 YL-------------QTQSSM----------YKISRIETTVSSVLSANDEDAEETTKSS------ 375

  Fly   483 RKRLSYQQEMQQRWSGPNSATAVTNSSSTANTTQLLSXQPAIQVVPPEMQTQIVCSSPYNNN 544
             ||||..               :|::.|:.:..:.:| .                ||.|:||
Frog   376 -KRLSLD---------------LTSNGSSRSVCKTMSDS----------------SSFYSNN 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TkR99D	NP_001263092.1	7tm_4	113..396	CDD:304433	125/282 (44%)
TkR99D	NP_001263092.1	7tm_1	118..381	CDD:278431	113/262 (43%)
tacr1	NP_001106489.1	7tmA_NK1R	33..315	CDD:320668	127/289 (44%)
		TM helix 1	34..60	CDD:320668	13/25 (52%)
		TM helix 2	67..93	CDD:320668	12/25 (48%)
		TM helix 3	105..135	CDD:320668	10/29 (34%)
		TM helix 4	146..167	CDD:320668	5/20 (25%)
		TM helix 5	193..222	CDD:320668	10/28 (36%)
		TM helix 6	241..271	CDD:320668	21/29 (72%)
		TM helix 7	283..308	CDD:320668	17/24 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	246	1.000	Domainoid score	I2128
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	314	1.000	Inparanoid score	I2521
OMA	1	1.010	-	-		QHG45276
OrthoDB	1	1.010	-	-		D314830at33208
OrthoFinder	1	1.000	-	-		FOG0000620
OrthoInspector	1	1.000	-	-		mtm9492
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X257
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.980