DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps13B and vps13c

DIOPT Version :9

Sequence 1:	NP_651753.2	Gene:	Vps13B / 43550	FlyBaseID:	FBgn0039727	Length:	3731	Species:	Drosophila melanogaster
Sequence 2:	XP_021327607.1	Gene:	vps13c / 798746	ZFINID:	ZDB-GENE-070426-4	Length:	3755	Species:	Danio rerio

Alignment Length:	4461	Identity:	798/4461 - (17%)
Similarity:	1443/4461 - (32%)	Gaps:	1513/4461 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ESYITPILLSYVAKYVKNFRDEDAQVSLWEGEVTFQNLDLRLEVLEEELNLPVELVSGHIHELSI 69
            ||.::.:|..::..||:|......::.:|.|.|..:||.::...| .||::|.::.:|.|.:|::
Zfish     4 ESLVSDLLNRFIGDYVENLDKSQLKIGIWGGNVVLENLKVKENAL-SELDVPFKVKAGQIGKLTL 67

  Fly    70 LVPWTKLMSEPV----------------------------------------------------- 81
            .:||..|.:|.|
Zfish    68 KIPWKNLYNEAVVATLDGLYLLVVPGATIKYDAVKEERYLQEAKQKELQRIEETLQLVARRDSQA 132

  Fly    82 -KIVINTIEFVAKLPDSESKQRRASFQREQRRKSKR--ESVEQPDQTKSPGPASSSSVVNKIINN 143
             :.|.|...:|.|.|..: |.|:....::..|:||:  ...|:|.:.|.  ...:..:..::|.|
Zfish   133 GEFVFNLESYVYKNPPRD-KGRKVKKHKKPFRRSKKYEHKAEKPQEEKK--DTFAEKLATQVIKN 194

  Fly   144 INLQCHNIILKYVEDDI-------VVSMNVQTLNFSSAGEDWKPTMVDIHPVSVVMRKLLQVSDL 201
            :.::..:|.::| |||:       .:.:.:..|:..:|.|:||..:  ::..:.::.||
Zfish   195 LQVKITSIHIRY-EDDVSDPQKPLAMGLTLSELSLQTADENWKTCI--LNEAAKIIYKL------ 250

  Fly   202 TICLDKRNTAGRIE-VC-----QEPVLYRCTLECRVLRKYNANTVSTTSTTRIGVFTKSLDINVS 260
                      ||:| .|     ..|:.|:.:.| .::.|..|           |:.||:.::...
Zfish   251 ----------GRLECFCAYWNVNGPIFYKDSWE-GIVEKLKA-----------GISTKNEELQGY 293

  Fly   261 SLQFPMVMRLVKMLLELKPAEFE-DDPQ---NPEDQEAVAEGSESQQGTESAGRSVFWWAWSLLP 321
            ...|..:....:|.:. ..||.| ..|:   :.|.|....|.::||          :.....||.
Zfish   294 QYIFKPIFASARMCIN-PNAEVELKSPKANLHLEVQNIAIEMTKSQ----------YLSMVDLLE 347

  Fly   322 SFDTEAPSSSCDTPTG--HAF--DLGVYAEELNFQLKNSEYFTDQSMGGIKRIRYTPILRISLGG 382
            |.|       |....|  ..|  |:.|:        :|:..:....:..|..:
Zfish   348 SID-------CMVKNGPYRKFRPDVPVH--------RNARQWWKYGISSILEV------------ 385

  Fly   383 LYYERTILKECDWANVKAGLSSMCMEPLGAYRSDDLVDRNLVNTQEFQQERSFIDKSLFDENYMF 447
              :.|...:..:|.|:|..     .:.|.||::     ...|...:..:.|...||.:.:
Zfish   386 --HVRRFNQMWNWTNIKKH-----RQTLKAYKA-----AYKVKLTQSAKVREDADKQIQE----- 433

  Fly   448 AERSWCSYNYADYVARNTDEYMLFRSPVLAFDVIEHRVPKPSSHPVAESQLRDLGVRIQYRLLSA 512
                         :.:..|.:.:    |||...::..|.:.....||:        :...:..|.
Zfish   434 -------------LEKGLDVFNI----VLARQQVQMEVVRSGQKLVAK--------KAATQKQSG 473

  Fly   513 GITFHFSQSFVQVKKVISDLIRPYDYPGYRSESMKDEDRGVPEPENKNSEMTIPDLEYLMGLVPT 577
            |   .|..||.                |.:....::||:   |||:.:|.||:.:...|...:
Zfish   474 G---GFFSSFF----------------GKKEGKKEEEDK---EPESIDSIMTVEEKSKLYTAI-- 514

  Fly   578 CNYKIELRNIVVQLYPRQQQDESSAINQHQLTTTVRQSLLPYLQLKISLVEGTMCGPVNPVRLVQ 642
             .|.....|:              |:.:|.:...|...|   |...::..|......:..|:::.
Zfish   515 -GYSGSSHNL--------------ALPKHYVAVIVNFKL---LSTSVTFREEPGVPEILKVQMID 561

  Fly   643 LITHLEEKP-RDVVNACYNCFHFNVKNLALM-----IMNTTPDNGRAKLLNIPRVQVNWNRLLAP 701
            |.|.:.::| ...:.......|:.|..|...     ::.:..|:. :.||:: |.::|.....|.
Zfish   562 LSTSISQRPGAQAIRVEAKLEHWYVTGLQQQGEVPSLIASLGDSD-SSLLSV-RFEINPEDSPAD 624

  Fly   702 HLWRQNEAPLETSEIKSEIITL-EFSKR------ELIIAKRLVPLISSFSGQDLCDLAHIV---- 755
            .|.|.:..|:|.......:|:: ||.|.      |:|.:..|..| .....:....|:||:
Zfish   625 QLLRVHSQPVEIIYDALTVISITEFFKTGKGVDLEVITSATLSKL-EEIKEKTATGLSHIIETRK 688

  Fly   756 ---ANVNVNSDVIKLQSVG---------------TKLNLVYHKYHTHL-AAVGSLQGVHTDAVHT 801
               ..:::....:.|...|               .:||.|....|..: |:..||:.:...|...
Zfish   689 VLDLRIDLKPSYLLLPKSGFYDGKSELMIVDFGYLQLNSVDQGGHQQVSASFSSLEEIMDRAYER 753

  Fly   802 -KMNIRNVVLSTSKNADNKWLEMQCQFPLEEVH----------------SEQEKIPGTVVCLWLE 849
             .:.:|:|.:..|::.: || :..|...|...|                .:..::|
Zfish   754 YSLELRSVQILYSRSGE-KW-KSACHEGLSHQHILQPMDFTLQLAKCMVDKDARMP--------- 807

  Fly   850 PFRITTDIYLLQFLNFSDN-------------------------SGRQI-------TKDK----- 877
            .|:::.::.||. |..||.                         :|:::       |:.|
Zfish   808 RFKVSGELPLLH-LKISDQKIQGVLELVDSIPLPQTGSSPPSSPTGKKVLGMPLSNTRPKVLALD 871

  Fly   878 -----------------EVETDLESVNQSEPPITQ------------SVSNYSTISASAIAFNDF 913
                             |...|.||:..:...:|:            .::..:......:||:..
Zfish   872 PTVLSYAVESESDEDTSEKSVDEESLRSTLEELTEVQFQFEVKAVLFELTRQAAQEDVVLAFSVS 936

  Fly   914 QPRRISRNNSRKISVPEETVHLSSER-DERHTQAEPLTIPVANKPQPSNFDTTDFVK-------- 969
            |.....|..:..:||......:|.:. :|:..|.:||.:..::....|:....:::|
Zfish   937 QLGAEGRIRTFDLSVTSYLKKISLDYCEEKDVQNQPLHLITSSDKHGSDLLKVEYIKADVNGPSF 1001

  Fly   970 ----RLTKMVVLVEIAQAKIDVCEVMMRKTPGHTDVEYTSIRLPHMKVKSGNCEAIQRGNI---- 1026
                ..|:..:.||.:.     .:.::......:.:.|.:..:|.....:...|..:|.:.
Zfish  1002 CTLFNNTEQTLKVEFSS-----LDFLLHTKALLSTINYMNSAIPQELTANKERETRRRADRAAAG 1061

  Fly  1027 RGVIPVASNTELLNWVFD--LNEFN--VCYRRANVTEM-----------------IIAPVRTTIT 1070
            :.|...:.:..::|:...  |..|.  ||..|:|:.::                 :.|.:|..:.
Zfish  1062 KTVSKGSKDAGVVNFKLSAVLGSFRVAVCDDRSNIADIRVQGIDASVMVQAKETDVFARLRDIVV 1126

  Fly  1071 LALSFKTSDKVDGS-KGKE---------------DKCANTCSINVHVDMSAINIFAQRVKLLHEH 1119
            |.:..||..|...| .|:|               |...:|..::..|.|   .:...::..||:.
Zfish  1127 LDVDPKTIHKKAVSIVGEEVFSFKMTLYPGATEGDGYTDTSKVDGKVIM---RLGCIQIVYLHKF 1188

  Fly  1120 CLIISKMYGSLCP--DEP-ASKWQTGKMKPRLEVYTGSAQNYPV--IKEF------LELDPNFEA 1173
            .:.:...:....|  ||. ...:||.  |..|...|..|.....  :::|      |.:|...:|
Zfish  1189 LMSLLDSFSYQYPSADEMFVDNFQTA--KEALSAATAQAAEKAASSVRDFAQKSFRLAMDIRLKA 1251

  Fly  1174 PKVKSAPKSSVILFCQWTIPRISFEMENSNDFKHSKIVMSLEDLLLNIDKHSDFNKITTKIENFG 1238
            |.: ..|:||.                     .|:..|:.|.  |:.:...  |:.:..  |.|.
Zfish  1252 PLI-IIPQSST---------------------SHNAFVVDLG--LITVGNR--FSLLAA--EGFP 1288

  Fly  1239 LNYYEEKHEEWEKIDDLHIKMLGDSTNLPLISVVITTVSLEDLYAKIGARNPHNKQHTISEVL-- 1301
            |.         ..::.:.||:    |.|.|...|:                .|:..|...|:|
Zfish  1289 LP---------AVLETMDIKL----TQLKLSRTVL----------------KHDADHLDIEILEP 1324

  Fly  1302 ---------------------IEVQPIEMVLNLDQITEFMVPICEVL-EII--GNSASAQSANKP 1342
                                 :||..:.|.:|:....|.:..:..:| |.|  |:.|:|....|.
Zfish  1325 INLELLVKRNLAAAWYNKIPGVEVNGVLMSMNMSLGQEDLGVLMRILAENIGEGSKAAAVEGTKA 1389

  Fly  1343 SAPVPSKIT--TVQDLPM-------------------VHLNSKGIYVYLPLSTGKKSCSVLLLRI 1386
            ||...:.|.  .:|.||:                   |.||.:...|.|.|...|.......|.:
Zfish  1390 SAKDEAVIDEGLMQTLPVGIGSLPALTNGAFTENVVNVLLNFEIKKVMLMLKKSKNGDESPFLVL 1454

  Fly  1387 ESIQLTPSLENPLVRQLVRPDIYQKAAELNMLSTPGALVEDRQYELSVRRVSLSTGNWKQTQEYR 1451
            :..||  .::..:.:..:....|.|...:..|..|.:..|    .|.:  :|.|..:.....|.:
Zfish  1455 DVSQL--GIDTKVRKYDMEATTYIKTISMKCLEFPDSNGE----PLCI--ISSSAESGADLLEVK 1511

  Fly  1452 IEKTLASKHDNPAFEWNNQSQSTELDHMEIFKDFDFIMIYAPAISYDRFLVCGQSVEYNCATDFV 1516
            ..|   :..:.|.|.  :..|:||.....:|...| :|::..|:.              ...||:
Zfish  1512 YFK---ADRNGPNFA--SLYQNTEQKMNVVFSSLD-LMLHTEALL--------------STMDFL 1556

  Fly  1517 -ASLNTHQISLISCIIVRAQRLGCIIDQVCVKNAELPK-ARSHKTLGNISKYNSVDNSIYFPADP 1579
             |:|:|                           :.||. .|..|...::...::...::..|:|.
Zfish  1557 SAALST---------------------------SSLPSPERESKKSEDMKTTSAKSTALSSPSDG 1594

  Fly  1580 KVFKKDTWIPKSSKKLVSERLSYTNASTSFTDAKGSSDYFYGSCQ-SDSGIHLGTRMKGY----- 1638
            .:.  |..:   :.:|.:..:...:..::..|.|...  ..||.| ..:..|:.||::.:
Zfish  1595 DII--DLMV---NMQLGAFNVLVCDQKSNMADIKIQG--LDGSLQMKGTQTHMFTRLRDFIVINV 1652

  Fly  1639 -SRSLAAEEINRSGRQPFVLSYPSSVSFVAGIFVLKIYDVLELEELERPVMKPLFLMTVSQPSFM 1702
             |:::..:.|:..|.:.|..|...:.....|........|....:|....::.::|    ...||
Zfish  1653 DSKTIHKKAISIVGDEVFSFSMSLTPKATEGAGYTDTSKVDGKVKLNVGCIQVVYL----HKFFM 1713

  Fly  1703 STQNFKAAVTQASIFNVNISVAKADVDGKVDSERFNESVFATLPGQLGSSGIPPPLLTIKTQYDR 1767
            |..||.....:|   ...:|.|.|....|..|                         :::....:
Zfish  1714 SLLNFSNNFQEA---KEALSAATAQAAEKAAS-------------------------SVRDFAQK 1750

  Fly  1768 LHQKEVDVELRKPILLRICENTIKQLASDVFRIYTVLHETPCFNVRSPRPVPE-----GSQLRQL 1827
            ..:..:|::|:.|:::....:|..........:.||.:......|.. ||:|.     ..||.||
Zfish  1751 SFRLAMDIKLKAPLIIIPQSSTSHNAVEADLGLITVGNRFSLLPVEG-RPLPAVIDNMDIQLTQL 1814

  Fly  1828 KMNCYNADRFHLSCDRITAKFYDEERSYKCSFVWLDVSTRIKFSSRPQKAVIRSNIGSFYVQSGE 1892
            |::            ||:.:...::.|.|
Zfish  1815 KLS------------RISMELDSDQTSSK------------------------------------ 1831

  Fly  1893 KMLLHPLLMRLSV--DLVSEPWSEELL---VNATLKLNYLHIDAGVFSILQLQKAQQGVNRIREY 1952
              ||.|:.:.|||  :|.|. |.:::.   |:..||...:.:.....|:| |:...:.:.   |.
Zfish  1832 --LLEPVNLVLSVKRNLASS-WYQKMAAIEVDGDLKPMKVALSQDDLSVL-LRILMENIG---EA 1889

  Fly  1953 ADREWQQFLRSRPVLGTPKDVSPCNLIKCTPSHESIERIKRPLKSNAEFYQDDLRAGAFQFVYLN 2017
            :|.:....||...||                       ::....:.:|..::.|
Zfish  1890 SDIQSDTALRQENVL-----------------------VRARTATGSEILEEKL----------- 1920

  Fly  2018 SESVLPMPYQVQIIKKNYGIICWRYPQPRQMTSIHIY---PVPMPVSRPIHIRCRMEYFSETHET 2079
            |||.|.....::.::.::.:         :...:.:|   |     |:|    |       .||.
Zfish  1921 SESKLKETELLESVRFSFNV---------ESLGLTLYNNDP-----SQP----C-------VHEE 1960

  Fly  2080 FLHYCDFML--SETSTKQLTPPDRPICATIWRVVIL---QSLISVDGTCFEGSEDEDLS-----I 2134
            .....:|||  .:.|.|.|...:..: :||.....|   :|.|....:...|..||:.|     :
Zfish  1961 KSCLGEFMLCKMKMSGKMLNNGNMEV-STILTTCTLDDRRSGIQRVTSRMLGRRDEETSEPMIDV 2024

  Fly  2135 EYLQSDFKVDENNDFILHPKVLVGCMRIDTVFRAEKVPKLQLLLCCQDIEL------NFV----- 2188
            .|.||   |||.:                      .|..||.|..|..:|.      .||
Zfish  2025 TYSQS---VDERS----------------------VVAVLQKLYLCASVEFLLAVADFFVQALPT 2064

  Fly  2189 ---NQTDNTGELP-KQLNKYRLRQTPNIT--------QTFLTVHVEDLQMHSRIYSRN------- 2234
               .|.:.|.:|| |.:::.::...|...        :|.|...|.|.::   ::..|
Zfish  2065 SPPTQREKTNQLPLKYVSEPKIHTEPKAVYLSSVPAQRTKLRAVVVDPEV---VFVANLMKADAP 2126

  Fly  2235 --------DFSLQTE-----MRARVKCLDY---------GFLNMLDVLEPMKFSSYVRL-TDYPR 2276
                    ||||.:|     |:|.|:.|..         |...:..||.|..    |.| |..|.
Zfish  2127 ALVASFQCDFSLLSEEAGQTMKANVRSLKVLACPFIRAEGDKAVTTVLRPCS----VELETKMPA 2187

  Fly  2277 SL-VQANFLVDKLRLNCGPHVIHTLLS-----SKYHWQEVLQQKDVRHVLMPKLVIVNRIQTPIS 2335
            :. :..:..|:::.:...|.:::|:::     :....:|:.|||....         |.:.:.:|
Zfish  2188 NAPLAGSMTVEEVIVKISPIILNTVITITAAMAPKPKEELSQQKSGDQ---------NSLWSLMS 2243

  Fly  2336 FGQTNTVEKIPVNPGEVQLYHFRSCSHVQELTFFITNPKTLLVDSS-DSVHIALKFEDEEKIHNL 2399
            ....|              |.|.......|:|...|:     |||| |.....|..:..:.....
Zfish  2244 VANAN--------------YWFLGVDTASEVTESFTD-----VDSSKDGETFGLTVKVVQVTLES 2289

  Fly  2400 RVGEYCITLKLAKLSTTQIYILVKGQIELVSMVPFNLVTEFREEEINYDESTPP--EHLLLSKER 2462
            .:|...:.|.||:.|.:   :..:....|:|      |:.....|:||...|..  |.||   ||
Zfish  2290 GLGHRTVPLLLAESSFS---VTAQNWSSLLS------VSADMTLEVNYFNETHAVWEPLL---ER 2342

  Fly  2463 SSYYQNVKRNADINMRLKLTAGLGRGRTGDIPLKTNNNLPWLVKVPTQSAQQFISIWVRILREDI 2527
               ..|.||..::.:.:|                   |.|...|.|.
Zfish  2343 ---VDNGKRRWNLKLDMK-------------------NNPVRDKSPV------------------ 2367

  Fly  2528 KMDKPAEDF----QPQ-KILICIWPIFEI-----C-NMLSCAVKA-TESTTGESSTIEAMGGRWA 2580
                |.:||    .|: .|.||......|     | |:.:...|| :|||   :||.:
Zfish  2368 ----PGDDFIMLPDPRTAITICSKDTMNITVSKCCLNVFNNLAKAFSEST---ASTFD------- 2418

  Fly  2581 LNTATTHATEHNIGFTFSGILRGSSKDEYSLMLRTMDWHKFFYYDPTVWTIENALHKLGKSSKRK 2645
                  |:.:....||....|..:...::|..||..                      |.|:
Zfish  2419 ------HSLKEKSPFTIRNALGVALIVQHSANLRVP----------------------GSST--- 2452

  Fly  2646 WPLNDPEELRVSRVLDFE-NAFD-VKYQTKATREFSCCQGLDVTAWG--------MFINGTGLYV 2700
              |....||.|.:.||.| ::|: ...|:...|:.||...|.:...|        :...|..||.
Zfish  2453 --LGKVHELAVDKSLDLEYSSFERSSRQSALQRQESCLFNLSIVPSGYSEISNIPLGKPGRRLYN 2515

  Fly  2701 AIFMIQEQA---RLDLKANSLQMMPKLKSAFTIDVRFDNGWKSSTPICLEDFTQKSSSNAGRSLY 2762
            ....:||::   .|.:.|:....:..::|...|...|      |.|..:    .|.||..|
Zfish  2516 VRQPMQEESVSVLLQIDASEGNKVITVRSPLQIKNHF------SVPFAI----LKYSSELG---- 2566

  Fly  2763 LRYNSFVDIVIVERDEVLRLILE-YRQE------DDGRRLFK---------------------LR 2799
                ..|::.:.|.::...:.|| ||.:      ....:|::                     |:
Zfish  2567 ----GMVNVGVAEPEKECHVPLEAYRSQLFLLPVGPLEKLYRASTTCIAWKEKVHVSSEVHAVLQ 2627

  Fly  2800 SKFVFTNFTDVVLNALTLAMDHKENSTREEVE-------------------AYSICKKARSLVSS 2845
            .....:||..:|:|.|.:..|....:...|||                   .|||    |.|:..
Zfish  2628 CPATESNFLPLVVNTLAMPDDLSHIANHGEVEWDPAYLIHLHPPVTVKNLLPYSI----RYLLEG 2688

  Fly  2846 ES--------------TKNCSGNAMDVFYDLNAHKAKH-------------------NCDT--AF 2875
            .:              ..|.||..|::.  |..::.::                   ||||  |.
Zfish  2689 SADIYELQEGSAADVLNSNVSGEIMELI--LIKYQGRNWTGRMRISRDMPEFITICFNCDTGEAL 2751

  Fly  2876 VYFVCF---SVGGSREISIPIPL-AVPFTRRCFSLQAGPESIPLMITLIEKDNVHYLNVFRDTAP 2936
            ...||.   .|.|...:|:..|. .:..|.|....:|            |...|.:.:.|||
Zfish  2752 TVDVCVHVSRVSGKFILSVHSPYWIINKTSRVLQYRA------------EDTFVKHPSDFRD--- 2801

  Fly  2937 AIVIS-------NNTNVKFIVAQTSASENSN---------VSCTNSE---FVGRNFEWNQLVLPH 2982
            .|:.|       :...::..|:.:|.||..:         |.|.:..   .||.:.:.:...|..
Zfish  2802 VILFSFKKKNIFSKNKLQLCVSTSSWSEGFSLDTVGSYGCVRCPDKSGDYLVGVSIQMSSFNLTR 2866

  Fly  2983 ---SNCYYTPPQMYANFPDVEFTMCNLSLAVYKDKLCAKNKIAW-------SKPIRTDKSWQK-- 3035
               .:.:||.         |..::..|.:...::...:.||  |       ..|...:.|.:|
Zfish  2867 IVTMSPFYTL---------VNKSLFELEVGEVQNNNGSSNK--WHYISSTECLPFWPESSTEKLC 2920

  Fly  3036 ----------------------FLHVPHHGD--VKVVVCDKHRAIRLNIYY-------IAQQLEF 3069
                                  .|.:..:|.  |.|.:.|....|....||       :......
Zfish  2921 VRVVGCESSSKSFFFNKQDSGTLLRMDQYGGVIVDVNISDHSTVISFTDYYDGAAPALVVNHTPS 2985

  Fly  3070 SVKDLRSRLTKPENVLMPSQEQ-------AAPR------PDESSEQE------------------ 3103
            :..:.|.|..:....|.|.:.|       |..|      .|.|.|.:
Zfish  2986 ATVNFRQRGCEECWALRPGEAQRFAWDDPAGVRKLCWSCQDHSGELDLVKDECGQFAYSSLVQIH 3050

  Fly  3104 -----NDTKRVTL----PNMVTCAHFNEECESKTQTRIKIFIKSFVFSLQTDNRENDFVKTEVCN 3159
                 :..:||.:    ..:||.|...||.| :.|..:.:.:::...||     .|:.::.|:..
Zfish  3051 WVSFLDGRQRVLIFTEDVGIVTKARQAEELE-QFQQEVNVSLQNLGLSL-----INNDIRQEIAY 3109

  Fly  3160 IYADDSMLIYD------------------------------------------------------ 3170
            :....|.::::
Zfish  3110 VGITSSGVVWEMRPKNRWKSFNHKNIGLLEKAYQNHINKSDPGWTMLETGIEVNFGRVPMLMRQP 3174

  Fly  3171 ------------------DDDDQRELRLQLPNLQVDNQLYSSGKYDFPVLLCAEKLYRRNCSLPQ 3217
                              ....||.||.||..|||||||..:   .||.:.       ....||:
Zfish  3175 FSCQIRRNFLPGIHVELKQSPHQRSLRAQLYWLQVDNQLPGA---IFPTVF-------HPVPLPK 3229

  Fly  3218 VYDLDHVYKQQAQRTP---VSLFT-FIFYQDEMQLQNVRCQIPPFRVYIEDAYLNQLLEALVECE 3278
                  ...|.::..|   ||:.| |..:...||.:.....:....|.|:..:|..:|
Zfish  3230 ------SIVQDSEPKPFIDVSIITRFNEHSQVMQFKYFMALVQEMAVKIDQGFLGAIL------- 3281

  Fly  3279 PSNCVYSPPVE-----QDQILLPAGMTLLPDQVVAQSLYISEPLR-LNSFTVEPLNLLLSVHTSS 3337
               .:::|..:     :...|:...:..|..|::..||..:..|. ...|.:.|:.|.||:...|
Zfish  3282 ---ALFTPATDSLDSKKKNKLIQKDLDALQAQLMESSLTDTSGLSFFEHFHISPIKLHLSLSLGS 3343

  Fly  3338 R-------------------------------LYIALDHSPLSFSRYERQQILTVPLRFGQSLGL 3371
            .                               |...|.:..:.:..|.|.:::...:|
Zfish  3344 SGDESEQGDMVAIQSVNLLLKSIGATLTDVDDLIFKLAYFEVKYQFYRRDKLMWAVIR------- 3401

  Fly  3372 HYLSGAIFGAGWVVGSLEILGSPSGLARSFSTGLRDFVSMPVQGLFRGPWGFLVGVTQGSASLLR 3436
            ||....:.....:|..|::||:|.||.|..|.|:..|...|:||..:||..|..|:..|..|||.
Zfish  3402 HYTEQFLTQMYVLVLGLDVLGNPFGLIRGLSEGVEAFFYEPIQGAVQGPEEFAEGLVIGVRSLLG 3466

  Fly  3437 NVTAGTVNSVTKLAGSVARNLDRLTLDAEHIELTEARRRA---RP-QGFADGLTQGLTGLGISLL 3497
            :...|....|:::.|||.:.|..:|:|.|:    :.:||.   || :.|.:.|.:|..|....::
Zfish  3467 HTVGGAAGMVSRITGSVGKGLAAITMDKEY----QQKRREEMNRPTKDFGESLAKGGKGFLKGVV 3527

  Fly  3498 GAVGGLAHHTLEA---RSSVGVIAGLTKGIVGALTKPISGAAEMLALTGQGVLHTVGFNAMPQQV 3559
            |.|.|:....:|.   ..:.|...|:.||:||.:.:|..|..:|.:.|.||:..
Zfish  3528 GGVTGIVTKPVEGAKKEGAAGFFKGIGKGLVGVVARPTGGIVDMASSTFQGIQR----------- 3581

  Fly  3560 EPSFIRNVALHGSSNRIWSYLPEELSRDQMLFFSEIMLQISTQLRPALLFLTSSVLAIMQ---SD 3621
                         ||:..:...||:                |:|||..|.....::....   |:
Zfish  3582 -------------SNQRVAESTEEV----------------TKLRPVRLIHEDGIIRPYDHHASE 3617

  Fly  3622 SEDLAFASPISKVDVLADREDPSKLYLSLKSERRDDFEGQLNYTNERIMKFLNASRLQSIANDSL 3686
            ..||...|.|.::|....||     :......|:.:    :..||.|:|
Zfish  3618 GYDLFQRSEIKQLDGEIFRE-----HYMYPGHRKTN----IMITNRRVM---------------- 3657

  Fly  3687 NDLLQLHELDVDDRIQRQSQCIF--YIKPNI---GEHLIHY 3722
                .:.|:||.....::.:|.|  :.:|..   |:..|:|
Zfish  3658 ----CVKEIDVIGHFNKEWECQFESFQRPPCTEGGDLKIYY 3694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps13B	NP_651753.2	Chorein_N	5..117	CDD:289396	33/167 (20%)
		VPS13_C	3319..3468	CDD:293514	44/179 (25%)
		ATG_C	3473..3546	CDD:286423	23/79 (29%)
vps13c	XP_021327607.1	Chorein_N	4..113	CDD:315323	23/109 (21%)
		VPS13	186..414	CDD:318996	55/308 (18%)
		VPS13_mid_rpt	614..838	CDD:318998	42/236 (18%)
		VPS13	<1245..>2613	CDD:330393	331/1811 (18%)
		SHR-BD	2766..3018	CDD:310922	45/277 (16%)
		VPS13	<3186..3635	CDD:330393	119/525 (23%)
		VPS13_C	3323..3498	CDD:318997	44/185 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000