DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps13B and Vps13b

DIOPT Version :9

Sequence 1:	NP_651753.2	Gene:	Vps13B / 43550	FlyBaseID:	FBgn0039727	Length:	3731	Species:	Drosophila melanogaster
Sequence 2:	NP_796125.2	Gene:	Vps13b / 666173	MGIID:	1916380	Length:	3993	Species:	Mus musculus

Alignment Length:	4299	Identity:	990/4299 - (23%)
Similarity:	1738/4299 - (40%)	Gaps:	1013/4299 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LESYITPILLSYVAKYVKNFRDEDAQVSLWEGEVTFQNLDLRLEVLEEELNLPVELVSGHIHELS 68
            ||||:||||:|||.:|:||.:..|.|:|||.|:|....|:|:|:|||:||.||...:|||||||.
Mouse     2 LESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSGHIHELR 66

  Fly    69 ILVPWTKLMSEPVKIVINTIEFVAKLPD----------SESKQRRASFQREQRRKSKRESVEQPD 123
            |.||||||.||||.|.|||:|.:.||.|          |.|..|..:...:...|.:|.....|.
Mouse    67 IHVPWTKLGSEPVVITINTMECILKLKDGIQDDHESCGSNSTNRSTAENTKSSIKPRRIQQAAPA 131

  Fly   124 QTKSPGPASSSSVVNKIINNINLQCHNIILKYVEDDIVVSMNVQTLNFSSAGEDWKPTMVDIHPV 188
            ....| |....|::.:::||:|:..:|:||||||||||:|:|:.:....:.||.|....:||...
Mouse   132 DPDLP-PGYVQSLIRRVVNNVNIVINNLILKYVEDDIVLSVNITSAECYTVGELWDRAFMDISAT 195

  Fly   189 SVVMRKLLQVSDLTICLDKRNTAGRIEVCQEPVLYRCTLECRVLRKYNANTVSTTSTTRIGVFTK 253
            .:|:||.:..||.|:||||||.:|:||..|:|:||:|:...|:...|:.......|..:|....:
Mouse   196 DLVLRKAINFSDCTVCLDKRNASGKIEFYQDPLLYKCSFRTRLHFTYDNLNSKMPSVIKIHTLVE 260

  Fly   254 SLDINVSSLQFPMVMRLVKMLLEL--------KPAEFEDDPQNPEDQEAVAEGSESQQGTES--- 307
            ||.::::..|.||.:|::::.:.|        |..|.||.|...:|..|...|:|.:...:.
Mouse   261 SLKLSITDQQLPMFIRIMQLGIALYYGEIGNFKDGETEDPPCLSKDTLANLTGTEEESRIDMQYP 325

  Fly   308 ---AGRSVF---------W--WAWSLLP---SFD--------TEAPS----SSCDTPTGHAFDLG 343
               .|:.::         |  ||||.:|   |:|        |:..|    ....|.......:|
Mouse   326 APYKGQELYSQDYEEPQGWVSWAWSFVPAIVSYDDGEEDDLGTDPASIMHQQKAQTLKDPIVSVG 390

  Fly   344 VYAEELNFQLKNSEYFTDQSMGGIKRIRYTPILRISLGGLYYERTILKE----CDWANVKAGLSS 404
            .|..:.....|.:|...:.|....::::...:|.....|...|..::.|    |....|  |..:
Mouse   391 FYCTKATVTFKLTEMQAENSYYSPQKVKSKEVLCWEQEGTTIEALMMGEPFFDCQIGFV--GCRA 453

  Fly   405 MCMEP-LGAYRSDDLVDRNLVNTQEF-------QQERSFIDKSLFDENYMFAERSWCSYNY---- 457
            ||::. ||....::.::|:......|       .:..:::..||||  |...|.:.....:
Mouse   454 MCLKGILGVKDFEEHMNRSETEACFFICGENLSTKGLTYLTNSLFD--YRSPENNGTRAEFILDA 516

  Fly   458 ADYVARNTDEYMLFRSPVLAFD---VIEHRVPK-PSSH---PVAESQLRDLGVRIQYR----LLS 511
            |.:...:||...:.|......|   .:||...| |:|.   |..:::  |||: :|.:    |:.
Mouse   517 AHHKETHTDIAGIQRFGAFYMDYLYTVEHSSGKGPTSQQDFPSGKNE--DLGI-VQEKSTKSLVI 578

  Fly   512 AGITFHFSQSFVQ--VKKVISDLIRPYD-YPGYRSESMKDEDRGVPEPENKNS-EMTIPDLEYLM 572
            ..:......|.|.  :|.::..|...|: |...:.|| |||...|.:||..:| |..||.....:
Mouse   579 GPLDCRLDSSAVHRVLKMIVCALEHEYEPYSRLKPES-KDEKETVLDPEEVSSLEEYIPTRHTSV 642

  Fly   573 GLVP-TCNYKIELRNIVVQLYPRQQQDESSAINQHQLTTTVRQSL--LPYLQLKISLVEGTMCGP 634
            .|:. ||...:...|::..|.|.....::|:   :....|..|||  ||.:|:.:..:......|
Mouse   643 TLLKCTCTVFMAEFNLLDCLLPVIMGGKNSS---NVTNATNFQSLRPLPSIQILVDKINLEHSVP 704

  Fly   635 VNPVRLVQLITHLEEKPRDVVNACYNCFHFNVKNLALMIMNTTPDNGRAKLLNIPRV----QVNW 695
            :...:||.:::.|.:...::::.||  .|..:|........|..|:..:..|..|.:    ...:
Mouse   705 MYAEQLVHVVSSLNQPSDNLLHYCY--VHCYLKVFGFQAGLTCLDHSGSYCLPAPIIPSFSTALY 767

  Fly   696 NRLL-APHLWRQNEAPLETSEI-KSEIITLEFSKRELIIAKRLVPLISSFSGQDLCDLAHI--VA 756
            .:|| .|.||.:....:.|..| :...:|::.::.:.::   |..:..|:|        ||  |:
Mouse   768 GKLLKLPALWTKRSQTVVTEGIFELPNLTIQATRAQTLL---LQAIYQSWS--------HIGNVS 821

  Fly   757 NVNVN----SDVIKLQSVGTKLNLVYHKYHTHLAAVGSLQGVHTDAVHTKM---------NIRNV 808
            :..||    ::|..:..|.:|..|.        ...||:|.|......|.:         :|:..
Mouse   822 SSTVNEALMNEVFPMTGVKSKNPLP--------TLEGSIQNVELKYCSTSLVKCASGTLGSIKIC 878

  Fly   809 VLSTSKNADNKWLEMQCQFPLE--EVHS----EQEKIPGTVVCLWLEPFRITTDIYLLQFLNFSD 867
            ..:...:...|.:.: .|.|.:  ::||    .:.:.|.::    |.|..|...|.:.|::::..
Mouse   879 AKAPGDSGKEKLIPL-LQGPSDTRDLHSSKWLNESRKPESL----LAPDLIAFTIQVPQYMDYCH 938

  Fly   868 NSGRQ-ITKDKEVETDLESV----------------NQSEP----PITQSVS------------- 898
            :||.. :...:.:..:::.:                .|.:|    |:..||:
Mouse   939 HSGAVFLCSVQGLAVNIDPILYTWVIYQPQKRANRHAQQQPVVAVPLVTSVNRRKEDELSIGSAP 1003

  Fly   899 --NYSTISASAIAFNDFQPRRISRNNSRKISVPEETV-----HLSSERDERH-------TQAEPL 949
              ...:..||..|.:..:.:.::  .||.:|||.:.|     ...|..|:..       ...:.|
Mouse  1004 LGKQQSYQASEYASSPIKTKTVT--ESRPVSVPVKAVLRVHEECRSPEDKMKEFIAILWNAVKSL 1066

  Fly   950 T-----------IPVANKPQPSNFDTTDFVKRLTKMVVLVEIAQAKIDVCEVMMRKTPGHTDVEY 1003
            |           ||..|.|.||...:.|....:....                    .|.|.:..
Mouse  1067 TLQLDVQSCCVFIPNDNLPSPSTIVSGDIPGTVRSWY--------------------HGQTSIPG 1111

  Fly  1004 TSIR-LPHMKVKSGN---CEAIQRGNIRGVI--PVASNTELLNWVFDLNEFNV-CYRRANVTEMI 1061
            |.:. ||.:|:.|..   .|.:|  .|..||  |:....:...|...|:.|:: ......||..:
Mouse  1112 TLVLCLPQIKIISAGHKYMEPLQ--EIPFVIPRPILEEGDAFPWTISLHHFSIYTLLGKQVTLSL 1174

  Fly  1062 IAPVRTTITLALSFKTSDKV--DGSKGKEDKCANTCSINVHVDMSAINIFAQ--RVKLLHEHCLI 1122
            :.|:..|.|||:   ||.|:  .|..|:     ::..:.:|||:.::.|...  :|:|::|....
Mouse  1175 VEPMGCTSTLAV---TSQKLLPVGPDGR-----HSFVVCLHVDLESLEIKCSNPQVQLIYELADT 1231

  Fly  1123 ISKMY------GSLCPDE----------PASK-WQT-GKMKPRLEVYTGSAQNYPVIKEFLELDP 1169
            :||::      |:|.|..          |.|. |.: |...|.....:.||          ::..
Mouse  1232 MSKVWSKIQKRGNLSPSSVYPETVAGPIPGSPVWSSVGTAPPDTSTCSPSA----------DIGT 1286

  Fly  1170 NFEAPKVKSAPKS--------------------SVILFCQWTIPRISFEMENSN-DFKHSKIVM- 1212
            ..|...|::...|                    .|.|:.||.:|:.:.::...: :.|.:::.|
Mouse  1287 TTEGDSVQAGDDSPFSDSVTLEQTTSNIGGSSGRVSLWMQWVLPKATVKLFAPDLEKKGTEVCMV 1351

  Fly  1213 -SLEDLLLNIDKHSDFNKITTKIENFGLNYYEEK-HEEWEK--IDDLHI----------KML-GD 1262
             .||||..:||....:.|:..|:|:|.:::|:.: .|.|:.  .:.:.:          |:| |.
Mouse  1352 SELEDLSASIDVQDVYTKVKCKVESFSIDHYQSRPGEGWQSGHFEGVFLQCKEKPVTTTKLLDGA 1416

  Fly  1263 STNLPLISVVITTVSLEDLYAKIGARNPHNKQHTISEVLIEVQP---IEMVLNLDQITEFMVPIC 1324
            ......:|:..|....:::..|:.:||.....:.:||.|::..|   .|::|:..   .|.:.:|
Mouse  1417 HQQHGFLSLTYTKAVTKNVRHKLTSRNERRSFYKLSEGLMDGSPHFLHEILLSAQ---AFDIVVC 1478

  Fly  1325 -EVLEIIGN-------SASAQSANKPSAPVPSKITTVQDLPMVHLNSKGIYVYLPLSTGKKSC-- 1379
             .:|..|.:       ....:.......|:.:...|.::||::::|:..|.:::|.:...:|.
Mouse  1479 FPLLNAIASVFHTKLPKTQREKRKSSGQPMRTHTLTSRNLPLIYINTSVIRIFVPQTEETQSTVA 1543

  Fly  1380 -------SVLLLRIESIQLTPSLENPLVRQLVRPDIYQKAAELNMLSTPGALVEDRQYELSVRRV 1437
                   ..::|::.||.:.|..:|||.|.::|.||||||..|.:|..||:.:|||||::.::.:
Mouse  1544 VNQAAKEDTMVLKVGSIAMAPQADNPLGRSVLRKDIYQKALNLGILRDPGSEIEDRQYQIDLQSI 1608

  Fly  1438 SLSTGNWKQTQEYRIEKTLAS---------KHDNPAFEWNNQSQSTELDHME-------IFKDFD 1486
            ::.|..|.|.:.   ||...|         ...|||.|||..|....  |.|       |..||.
Mouse  1609 NIGTAQWDQLKP---EKGSGSGGVPTESERNSQNPALEWNMASSIQR--HQERRAILTPILTDFS 1668

  Fly  1487 FIMIYAPAISY-----------DRFLVCGQSVEYNCATDFVASLNTHQISLISCIIVRAQRLGCI 1540
            ..:..||||.:           :..||||.|:|.|..|:....|:..|:.|:..:|| |...|.
Mouse  1669 VRITGAPAIIFTKIISQENLHMEEILVCGHSLEVNITTNLDFFLSVAQVQLLHQLIV-ANMTGL- 1731

  Fly  1541 IDQVCVKNAELPKARSHK-------TLGNISKYNSVDNSIYFPADPKVFKKDTWIPKSSKKLVSE 1598
              :...|..|:.|....|       |....|:|:..              :|:.|...|.|:...
Mouse  1732 --EPSTKATEISKQEQKKVDTFDGGTAETSSRYSGA--------------QDSGIGSDSVKIRIV 1780

  Fly  1599 RLSYTNASTSFTDAKGSS-------------DYFYGSCQSDSGIHLGTRMKGYSRSLA------- 1643
            ::...:.::....|:.|.             |.|.    :.|.|.|.|    || |:|
Mouse  1781 QIEQYSGASQHRIARPSHQSSIVKNLNFIPFDIFI----TASRISLMT----YS-SVALPKFKLP 1836

  Fly  1644 -AEEINRSGRQPFVLS----------------------YPSSVSFVAGIFVLKIYDVLELEELER 1685
             .:|..::||....|:                      ..||.||.:|    |...||.||.|..
Mouse  1837 EQKEDGKTGRTFLNLAEVDSDVAKPNQACVSMVTAEDPLSSSTSFSSG----KKVRVLSLESLHA 1897

  Fly  1686 P-------------VMKP-----------LFL-MTVSQPSFMSTQNFKAAVTQASIFNVNISVAK 1725
            .             |.:|           ||| :.|||||.:.:.:.:....:.|||:..:....
Mouse  1898 STRSSARQALGVTVVRQPGRRGTGDLELDLFLHLIVSQPSLLLSCHHRKQRVEVSIFDAMLKGVP 1962

  Fly  1726 ADV----DGKV--DSERFNESVFATLPGQLGS-SGIPPPLLTIKTQYDRLHQK-------EVDVE 1776
            :|.    .||.  ::..:|.....|:||:..| |||||.|:|       ||.|       ::.::
Mouse  1963 SDYTCTDPGKTLPEASDYNIVWLQTVPGETDSKSGIPPSLVT-------LHIKDFLNGPADIYLD 2020

  Fly  1777 LRKPILLRICENTIKQL---ASDVFRIYTVLH----ETP---CFNVRSPRPVPEGSQLRQLKMNC 1831
            :.||:...:....:.|:   ...:.:.::..|    .||   ..|:..| |||:          |
Mouse  2021 VSKPLKANLSFTKLDQINHFLKKIKKAHSSAHSKETSTPSDSILNMDEP-PVPK----------C 2074

  Fly  1832 YNA--DRFHLSCDRITAKFYDEE--RSYKCSFVWLDV-STRIKFS----SRPQKAVIRSNI---- 1883
            |..  .:..:.||......:.|.  |:..| |..:.| :|:|..|    ..|.|..:.:::
Mouse  2075 YRGKLSKTKVHCDEAQKTSFQENIWRAISC-FQKVSVHTTQIVVSMETVPHPHKPCVLASLSNLN 2138

  Fly  1884 GSFYVQSGEK-----------MLLHPLLMRLSVD----LVSEPWSEELLVNATLKLN-------- 1925
            ||..|::.:|           :.:|.:|::.|:.    ::..|:|      ||:.|.
Mouse  2139 GSLTVKAAQKVPGASLGSSFLLSIHDVLLKTSLKERSRILIGPFS------ATVNLEAKWCKHSG 2197

  Fly  1926 -----------YLHIDAGVFSILQLQKAQQGVNRIREYADREWQQFLRSRPVLGTPKDVSPCNLI 1979
                       .:.:..|:..:...|:....:..:.|..:...|:.....||
Mouse  2198 NPGPQQSIPKISMDLRGGLLQVFWGQEHLNCLALLHELFNGYLQEGKSEMPV------------- 2249

  Fly  1980 KCTPSHESIERIKRPLKSNAEF----YQDDLRAGAFQFVYLNSESV-LPMPYQVQI---IKKNYG 2036
                 .||..::..|::....|    ..||||.|.||:|. ::||: ||..|:|..   .:::.|
Mouse  2250 -----PESAPQMPSPVEKTQAFKTEQSSDDLRTGIFQYVQ-DAESLKLPGVYEVLFYNETEESPG 2308

  Fly  2037 IICWRYPQPRQMTSIHIYPVPMPVSRP-----------IHIRCRMEYFSETHETFLHYCDFMLSE 2090
            ::.||||:||.:|.:.|.|||...:..           :.:.|.:||:.|..:.|:.:.:|.|||
Mouse  2309 MMLWRYPEPRVLTLVRITPVPFNTTEDPDISTADLGDVLQVPCGLEYWDELQKVFVAFQEFSLSE 2373

  Fly  2091 TSTKQLTPPD--------RPICATIWRVVILQSLISVDGTCFEGSEDEDLSIEYLQSDFKVDENN 2147
            :...:|..||        :.:.:.:||:|:..:..:.|.   :.|..|..|    ||..:.
Mouse  2374 SKVCELQLPDINLVHDQKKLVSSDLWRIVLNNNQNTTDD---QSSASESGS----QSTCEP---- 2427

  Fly  2148 DFILHPKVLVGCMRIDTVFRAEKVPKLQLLLCCQDIELNFVNQTDNTGEL-PKQLNKYRLRQTPN 2211
              ::.|..|..|.|:|:.|....||.|.:......:|....:..|..|.. |:.|..:...:...
Mouse  2428 --LVTPTALAACTRVDSCFTPWFVPSLCMSFQFAHLEFRLCHHLDQLGTASPQYLQPFISDKNVP 2490

  Fly  2212 ITQTFLTVHVEDLQMHSRIYSRNDFSLQTEMRARVKC--LDYGFLNMLDVLEPMKFSSYVRL-TD 2273
            ....::.:...:..:|.|.::......:.:..:::.|  |:...:.|..|::|......:.| :|
Mouse  2491 SELEYMIISFREPNLHLRQWNSGPVCQEIKFSSQMDCKLLECRNVTMQTVVKPFGICGQMALSSD 2555

  Fly  2274 YPRSLVQANFLVDKLRLNCGPHVIHTLLSSKYHWQEVLQQK--DVRHVLMPKLVIVNRIQTPISF 2336
            ..:.|:.:..:||.:.:|.|.||:|:|.::...||   |.|  :|..::....||.|..|..:.|
Mouse  2556 GVQKLLDSTVIVDSVLVNFGQHVVHSLNTAIQAWQ---QNKCPEVEELVFSHFVICNDTQETLRF 2617

  Fly  2337 GQTNTVEKIPVNPGEVQLYHFRSCSHVQELTFFI--------TNPKTLLVDSSDSVHIALKFEDE 2393
            ||.:|.|.|.:.......|.:||....|.|...|        :.|.|  ||.:.:....::::..
Mouse  2618 GQVDTDENILLASLHSHQYSWRSHKSPQLLHICIEGWGNWRWSEPFT--VDHAGTFIRTIQYKGR 2680

  Fly  2394 EKIHNLRVGEYCITLKLAKLSTTQIYILVKGQIELVSMVPFNLVTEFREEEINYD-ESTPPEHL- 2456
            ..         .:.:|:..||..|..|::.|:..:.|.:..::..:..:..|..| ::...||.
Mouse  2681 TA---------SLIIKVRALSGVQKQIIICGRQIICSYLSQSIELKVVQHYIGQDGQAVVREHFD 2736

  Fly  2457 -LLSKERSSYYQNVKRNADINMRLKLTAGLGRGRTGDIPLKTNNNLPW---------------LV 2505
             |.:|::...|  :..|.::.               ::.:|...:..|               ::
Mouse  2737 CLTAKQKLPSY--ILENNELT---------------ELCVKAKGDEDWSRDVCLEPKASEYSTVI 2784

  Fly  2506 KVPTQSAQQFISIWVRILREDIKMDKPAEDFQPQKILICIWPIFEICNMLSCAVKATESTTGESS 2570
            :||| |....|.:|..:|..:       .:.|.|:.:|...|:|.:.:.|.
Mouse  2785 QVPT-SNSSIIYVWCTVLTLE-------PNSQVQQRMIVFSPLFIMRSHLP-------------- 2827

  Fly  2571 TIEAMGGRWALNTATTHATEHNIGFTFSGILRGSSKDEYSLMLRTMD----WHKFFY----YDPT 2627
                       :....|..:.::|.:.:.|:.|..::.   .|:.::    .|..|.    |||:
Mouse  2828 -----------DPIIIHLEKRSLGLSETQIIPGRGQEN---PLQNVEPDLVHHLTFQAREEYDPS 2878

  Fly  2628 --VWTIENALHKL---------------------GKSSKRKWPLNDPEELRVSRVLDFENAFDVK 2669
              ...|..||.|.                     .||.:..||.::.:..|..::..:::...||
Mouse  2879 DCAVPISTALIKQIATKIQPGGTVNEMLDEFYGPEKSQEPTWPYSNKDSDRNEQLSQWDSPMRVK 2943

  Fly  2670 YQTKATREFSCCQGLDVTAWGMFINGTGLYVAIFMIQEQARLDLKANSLQMMPKLKSAFTIDVRF 2734
              ....:.:.....:::..|.:.||.:...:.:|. .|:..|.:.|..:.:.|..:.||.|.:.:
Mouse  2944 --LSIWKPYVRTLLIELLPWALLINQSKWDLWLFE-GEKIVLQVPAGKIIIPPNFQEAFQIGIYW 3005

  Fly  2735 DNG---WKSSTPICLEDFTQ---KSSSNAGRSLYLRYNSFVDIVIVERDEVLRL--------ILE 2785
            :|.   .|:.....:.:.|.   |...| |..:.|...:|||..|       ||        :.:
Mouse  3006 ENTNTVHKTLAIKLVHNLTSPKWKDGGN-GEVVTLDEEAFVDAEI-------RLGAFPGHQKLCQ 3062

  Fly  2786 Y---RQEDDGRRLFKLRSKFVFTNFT--DVVLN---ALTLAMDHKENSTREEVEAYSICKKARSL 2842
            :   .....|.::.::..|....|.|  .:|..   |::.:...||:....:...:|||......
Mouse  3063 FCISSMVQHGIQVIQIEDKTTVINNTPYQIVYKPHLAISNSYSGKEHCHVPDSATFSICPGGEHP 3127

  Fly  2843 VSSESTKNCSGNAMDVFYDLNAHKAKHNCDTAFVYFVCFSVGGSREISI---PIPLAVPFTRRCF 2904
            ....|:..|        :|:.........|||.:         .::|.:   |:|.|  .:.:|:
Mouse  3128 AVRSSSLPC--------WDVTPAVGSSELDTATL---------QKQILLGFSPVPGA--DSAQCW 3173

  Fly  2905 SLQA--GPE------SIP-------------LMITLIEKDNVHYLNVFRDTAPAIVISNNTNVKF 2948
            ||.|  |.|      ::|             :.:|..|...|.|:.:..|.:|.:|..|...|..
Mouse  3174 SLPAIIGGEFPRQSVAVPFGTGRENGFCTRAIALTYQEHLGVTYITLSEDPSPRVVFHNRCPVPM 3238

  Fly  2949 IVAQTSAS-ENSNVSCTNSEFVGRNFEWNQLVLPHSNCYYTPPQMYANFPDVEFTMCNLSLAVYK 3012
            ::.:.... ...:|.|             :.:.|.|:.::.......::||.:......||.:..
Mouse  3239 LMKENIRDIPKFDVYC-------------KKIPPESSVHHELYHQIISYPDCKTKDLLPSLFLRI 3290

  Fly  3013 DKLCAKNKIAWSKPIRTDKSWQKFLHVPHHGDVKVVVCDK---------------------HRAI 3056
            |.: .:....||.|:..:....:.:.:...|.|.|.:..:                     .||:
Mouse  3291 DSM-EEMTAEWSDPVDINSQGTQVVFLTGFGYVYVDIAQQCGTVFIILAPEGKAGPIFTSTSRAL 3354

  Fly  3057 RLNIYY--IAQQLEFSVKDLRSRLTKPENVLMPSQEQAAPRPDESSEQENDTKRVTLPNMVTCAH 3119
            ...:.:  ...||..:|.|                       |.:.:..::..|:||.|
Mouse  3355 ERMVTFRMFITQLSLAVSD-----------------------DLTHQAPSELLRLTLDN------ 3390

  Fly  3120 FNEECESKTQTRIKIFIKSFVFSLQTDNRENDFVKTEVCNIYADDSMLIYDDDDDQRELRLQLPN 3184
                        :.:.:......|..:...:.|.:.....:|..|
Mouse  3391 ------------VFLHVSPVPALLPGEEPPSSFFQLYGVEVYCGD-------------------- 3423

  Fly  3185 LQVDNQLYSSGKYDFPVLLC---------------------AEKLYRRNCSLPQVYDLDHVYKQQ 3228
            ||:|||||:...:.|.||:|                     |.:.|:.||.:.....   |.:.:
Mouse  3424 LQLDNQLYNKSNFHFAVLVCQGERTDPAQYSRVQSLLVSSKALEEYKENCFIKLCLT---VSEGK 3485

  Fly  3229 AQRTPVSLFTFIFYQDEMQLQNVRCQIPPFRVYIEDA---YLNQLLEALVECEPSNCVYSPP--V 3288
            .....||.|||              ::.|.|:|:||.   |:..|.:          .|.||  :
Mouse  3486 DILLDVSEFTF--------------ELKPARLYVEDTFVYYIKTLFD----------TYLPPSRM 3526

  Fly  3289 EQDQILLPAGMTLLPDQVVAQSLYISEPLRLNSFTVEPLNLLLSVHTSSRLYIALDHSPLSFSRY 3353
            ......|..|..:||.||...:..:...::|....::|:|||:|:|.|.:||||.||:|||||.:
Mouse  3527 SGHHAQLFTGQQVLPVQVTQHAKALVNAVKLRKLLIQPVNLLISIHASLKLYIASDHTPLSFSVF 3591

  Fly  3354 ERQQILTVPLRFGQSLGLHYLSGAIFGAGWVVGSLEILGSPSGLARSFSTGLRDFVSMPVQGLFR 3418
            ||..:.|...:...:|.:||.:||:|.||||||||||||||:.|.||...|:.||..:|.:||.|
Mouse  3592 ERGPVFTTARQLVHALAMHYAAGALFRAGWVVGSLEILGSPASLVRSIGNGISDFFRLPYEGLTR 3656

  Fly  3419 GPWGFLVGVTQGSASLLRNVTAGTVNSVTKLAGSVARNLDRLTLDAEHIELTEARRRARPQGFAD 3483
            ||..|:.||::|:.|.:::::.|.:.|:|.||.|:|||:.||:||.||....|..||..|:...:
Mouse  3657 GPGAFVSGVSRGTTSFVKHISKGALTSITNLATSLARNMGRLSLDEEHYNRQEEWRRQLPESLGE 3721

  Fly  3484 GLTQGLTGLGISLLGAVGGLA-------HHTLEARSSV-----GVIAGLTKGIVGALTKPISGAA 3536
            ||.|||:.||||||||:.|:.       ..|.|.::|.     |||:|:.|||:|..||||.|||
Mouse  3722 GLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSETQASAGHKAKGVISGVGKGIMGVFTKPIGGAA 3786

  Fly  3537 EMLALTGQGVLHTVGFNAMP-QQVEPSFI-RNVALHGSSNRIWSYLPEELSRDQM-LFFSEIMLQ 3598
            |:::.||.|:||..|.:.:| |:.:|:.: .:.|.:.....:|..| :.|.|.:: :....::::
Mouse  3787 ELVSQTGYGILHGAGLSQLPKQRCQPTHLYADQAPNSHVKYVWKML-QSLGRPEVHMALDVVLVR 3850

  Fly  3599 ISTQLRPALLFLTSSVLAI--MQSDSEDLAFASPISKVDVLADREDPSKLYLSLKSER-RDDFEG 3660
            .|.|.....|.|||.||.:  :..|::..||  ||:::....|.:..:.|.:.||..| ..|.|
Mouse  3851 GSGQEHEGCLLLTSEVLFVVSISEDTQQQAF--PITEISCAQDTKQNNLLTVQLKQPRVASDVE- 3912

  Fly  3661 QLNYTNERI 3669
             ::...||:
Mouse  3913 -IDGARERL 3920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps13B	NP_651753.2	Chorein_N	5..117	CDD:289396	60/121 (50%)
		VPS13_C	3319..3468	CDD:293514	74/148 (50%)
		ATG_C	3473..3546	CDD:286423	38/84 (45%)
Vps13b	NP_796125.2	Chorein_N	3..102	CDD:315323	56/98 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..133		6/32 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1262..1303		9/50 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1616..1637		4/23 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1735..1770		8/48 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2048..2067		4/18 (22%)
		SHR-BD	<2605..>2685	CDD:310922	20/90 (22%)
		VPS13_C	3557..3703	CDD:318997	72/145 (50%)
		ATG_C	3705..3809	CDD:312735	44/103 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	386	1.000	Domainoid score	I801
eggNOG	1	0.900	-	-		E1_COG5043
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	761	1.000	Inparanoid score	I546
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46865
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008361
OrthoInspector	1	1.000	-	-		oto95368
orthoMCL	1	0.900	-	-		OOG6_106252
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1642
SonicParanoid	1	1.000	-	-		X10428
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.850