Protein Alignment Vps13B and VPS13D

DIOPT Version :9

• Sequence 1: NP_651753.2
• Gene: Vps13B / 43550
• FlyBaseID: FBgn0039727
• Length: 3731
• Species: Drosophila melanogaster
• Sequence 2: NP_056193.2
• Gene: VPS13D / 55187
• HGNCID: 23595
• Length: 4388
• Species: Homo sapiens
• Alignment Length: 4757
• Identity: 842/4757 - (17%)
• Similarity: 1472/4757 - (30%)
• Gaps: 1733/4757 - (36%)

  Fly     4 LESYITPILLSYVAKYVKNFRDEDAQVSLWEGEVTFQNLDLRLEVLEEELNLPVELVSGHIHELS 68
            ||..:..:|.:|:.|||.|...:...|:|.:|.|..:||.|:.:.| :||.||.|:.:|.|.:::
Human     2 LEGLVAWVLNTYLGKYVNNLNTDQLSVALLKGAVELENLPLKKDAL-KELELPFEVKAGFIGKVT 65

  Fly    69 ILVPWTKLMSEPVKIVINTIEFVA---KLPDSESKQRRASFQREQRRKSKRESVEQ------PDQ 124
            :.:|:.:...:|..|.|:::..:.   |:.|...::.:. .:|| |:|:..:::|:      ..:
Human    66 LQIPFYRPHVDPWVISISSLHLIGAPEKIQDFNDEKEKL-LERE-RKKALLQALEEKWKNDRQQK 128

  Fly   125 TKSPGPASSSSVVNKIINNINLQCHNIILKYVEDDI-------VVSMNVQTLNFSSAGEDWKPTM 182
            .:|...:.::|||.:|:.||.|:..::.|:: ||.:       ...:.::.::..:|..:
Human   129 GESYWYSVTASVVTRIVENIELKIQDVHLRF-EDGVTNPSHPFAFGICIKNVSMQNAVNE----- 187

  Fly   183 VDIHPVSVVMR-KLLQVSDLTICLD------------------KRNTAGRI-EVCQEPVLYRCTL 227
                ||..:|| |.|.|::.:|..|                  .|:...|. ....|||.....|
Human   188 ----PVQKLMRKKQLDVAEFSIYWDVDCTLLGDLPQMELQEAMARSMESRSHHYVLEPVFASALL 248

  Fly   228 ECRVLRKYNANTVSTTSTTRI--GVFTKSLDINVSSLQFPMVMRLVKMLLELKPAEFE------- 283
            :    |..:...:.:..:.||  .:..:::.:.:|.||:..:|..:|. ||.|..:.:
Human   249 K----RNCSKKPLRSRHSPRIDCDIQLETIPLKLSQLQYRQIMEFLKE-LERKERQVKFRRWKPK 308

  Fly   284 ----------------------------------------------------------------- 283
                                                                             
Human   309 VAISKNCREWWYFALNANLYEIREQRKRCTWDFMLHRARDAVSYTDKYFNKLKGGLLSTDDKEEM 373

  Fly   284 ---DDPQNPED--------------QEAVAEGSESQQ--------GTESAG---------RSVF- 313
               ::.|:.|:              ||.:||.....|        |....|         :|.|
Human   374 CRIEEEQSFEELKILRELVHDRFHKQEELAESLREPQFDSPGACPGAPEPGGGSGMLQYLQSWFP 438

  Fly   314 -WWAW--------------------SLLPS--------FDTEAPSSSCDTPT--GHAFDLGVYAE 347
             |..|                    ..:|.        ||..|.:|..:|.|  .|.|      .
Human   439 GWGGWYGQQTPEGNVVEGLSAEQQEQWIPEEILGTEEFFDPTADASCMNTYTKRDHVF------A 497

  Fly   348 ELNFQLK----------------NSEYFTDQSMGGIKRI------RYTPILRISLGGLYY----- 385
            :||.||:                |...|.......:|.:      |.:.:|.:.||||:.
Human   498 KLNLQLQRGTVTLLHKEQGTPQMNESAFMQLEFSDVKLLAESLPRRNSSLLSVRLGGLFLRDLAT 562

  Fly   386 ERTIL---------KECDWANVKAGLSSMCMEPLGAYRSDD--------LVDRN----------- 422
            |.|:.         ||....:...||.:...:....|.:.|        |.:||
Human   563 EGTMFPLLVFPNPQKEVGRVSQSFGLQTTSADRSDHYPAADPDGPVFEMLYERNPAHSHFERRLN 627

  Fly   423 --------LVNTQEFQQERSFIDKSLF---------DENYMFAERSWCSYNYADYVARNTDEYML 470
                    :.|.|..::...|..|...         :.....||.:...||......:......|
Human   628 VSTRPLNIIYNPQAIKKVADFFYKGKVHTSGFGYQSELELRVAEAARRQYNKLKMQTKAEIRQTL 692

  Fly   471 FRSPVLAFDVIEHRVPKPSSHPVAESQLRDLGVRIQYRL-LSA-GITFHFSQSFVQVKKVISDL- 532
            .|  :|..|.||            ||:      |...|| :|| .:.|.....|.....|:.||
Human   693 DR--LLVGDFIE------------ESK------RWTVRLDISAPQVIFPDDFKFKNPVLVVVDLG 737

  Fly   533 ----------IRPYDYPGYRSESMKDED----------RGVPEPE--NKNSEMTIP------DLE 569
                      .|.....|..||..:..|          ...|.||  :.|.|.|.|      ..|
Human   738 RMLLTNTQDNSRRKSRDGSASEETQFSDDEYKTPLATPPNTPPPESSSSNGEKTPPFSGVEFSEE 802

  Fly   570 YLMG-LVPTCNY-KIELRNIVVQLYPRQQQDESSAINQHQL-TTTVRQSLLPYLQLKISLV---E 628
            .|.. |:.|..| :..|..:.:|:...:.:|....:....: .|.|.:....:|||:..|:   :
Human   803 QLQAHLMSTKMYERYSLSFMDLQIMVGRVKDNWKHVQDIDVGPTHVVEKFNVHLQLERRLIYTSD 867

  Fly   629 GTMCGPVNPVRLVQLITHLEEKPRDVVNACYNCFHFNVKNLALMIMNTTPDNGRAKLLNIPRVQV 693
            ....|.|....|..|..|:.|   |.::|..|||       ||:   |||:      :.....|:
Human   868 PKYPGAVLSGNLPDLKIHINE---DKISALKNCF-------ALL---TTPE------MKTSDTQI 913

  Fly   694 NWNRLLAPHLWRQNEAPLETSEIKSEIITLEFSKRELIIAKRLVPLISSFSGQDLCDLAHIVAN- 757
              ...:.|...::.........:...|:.||...||:::..:|:             ||....|
Human   914 --KEKIFPQEEQRGSLQDSVMNLTQSIVLLEQHTREVLVESQLL-------------LAEFKVNC 963

  Fly   758 ----VNVNSDVIKLQSV-GTKLNLVYHKYHTHLAAVGSLQGVH----TDAVHTKMNIRNVVLSTS 813
                |..|...|.:..| ||..:.|...|...::..     ||    .|.:.|.....::::::.
Human   964 MQLGVESNGRYISVLKVFGTNAHFVKRPYDAEVSLT-----VHGLLLVDTMQTYGADFDLLMASH 1023

  Fly   814 KNADNKWLEMQCQFPLEEVHSE--QEKIPGTVVCLWLEPFRITTDIYLLQFLNFSDNSGRQITKD 876
            ||       :....|...:...  |..:.|..|.            :|......:|.|...::.|
Human  1024 KN-------LSFDIPTGSLRDSRAQSPVSGPNVA------------HLTDGATLNDRSATSVSLD 1069

  Fly   877 KEVETDLESVNQSEPPITQSVSNYSTISASAIAFN---DFQPRRISRNNSRKISVPEETVHL--- 935
            |.:..:.||:.:.|         |..:|:...:.|   ..|...:..||...|..||..|.|
Human  1070 KILTKEQESLIKLE---------YQFVSSECPSMNLDSTLQVISLQVNNLDIILNPETIVELIGF 1125

  Fly   936 -----SSERDERHTQAEPLTIPVANKPQPSNFDTTDFVKRLTKM-----------VVLVEIAQAK 984
                 ..|:|:.             .|||.   .|||.:...:.           .|.|||.:..
Human  1126 LQKSFPKEKDDL-------------SPQPL---MTDFERSFREQGTYQSTYEQNTEVAVEIHRLN 1174

  Fly   985 IDVCEVMMRKTPGHTDVEYTSIRLPHMKV--------------KSGNCEAIQ-----RGNIRG-- 1028
            :     ::.:|.|..:.|....::....:              .:|:...:|     :.|::.
Human  1175 L-----LLLRTVGMANREKYGRKIATASIGGTKVNVSMGSTFDMNGSLGCLQLMDLTQDNVKNQY 1234

  Fly  1029 VIPVASNTELLNWVFDLNEFNVCYRRANVTEMIIAPVRTTITLALSFKTSDKVDGSKGKEDKCAN 1093
            |:.:.::....|.:.|:..|...:.|..         ...:|.||||...:     :.|::...|
Human  1235 VVSIGNSVGYENIISDIGYFESVFVRME---------DAALTEALSFTFVE-----RSKQECFLN 1285

  Fly  1094 TCSINVHVDMSAINIFAQRVKLLHEHCLIISKM----YGSLCPDEPASKWQTGKMKPRLEVYTGS 1154
            ....::|.:.||        |.|.|..|.:.::    .|.|         ::...|....:.|.:
Human  1286 LKMASLHYNHSA--------KFLKELTLSMDELEENFRGML---------KSAATKVTTVLATKT 1333

  Fly  1155 AQNYPVIKEFLELDPNFEAPKVKSAPKSSVILFCQWTIPRISFEMENSN--DFKHSKIVMSLEDL 1217
            |       |:.|:...||.|:....|                |.:|.:.  .|..:...:....|
Human  1334 A-------EYSEMVSLFETPRKTREP----------------FILEENEIYGFDLASSHLDTVKL 1375

  Fly  1218 LLNIDKHSDFNKITTK---------------IENFGLNYYEEKHEEWEKIDDLHIKMLGDSTNLP 1267
            :|||:..|....|..|               |:||...      ::..:.|.|.:::    .::.
Human  1376 ILNINIESPVVSIPRKPGSPELLVGHLGQIFIQNFVAG------DDESRSDRLQVEI----KDIK 1430

  Fly  1268 LISVVITTVSLEDLYAKIGAR---------------NPHNKQHTISEVL---------------- 1301
            |.|:..|.::..:.....|:|               ..|..:|...|.|
Human  1431 LYSLNCTQLAGREAVGSEGSRMFCPPSGSGSANSQEEAHFTRHDFFESLHRGQAFHILNNTTIQF 1495

  Fly  1302 -IEVQPIE------MVLNLDQI---------TEFMVPIC---------EVLEIIGN--------- 1332
             :|..|||      ..|:.|.:         .:|:.|:.         :||:.:.|
Human  1496 KLEKIPIERESELTFSLSPDDLGTSSIMKIEGKFVNPVQVVLAKHVYEQVLQTLDNLVYSEDLNK 1560

  Fly  1333 -SASAQSANKPSAPVPSKITTVQDLPMVHLNSKGIYVYLPLS-TGKKSCSV-------------- 1381
             .|||.|:..|.:|:|...|..:.  .|.....|::.:..|| |.:||.||
Human  1561 YPASATSSPCPDSPLPPLSTCGES--SVERKENGLFSHSSLSNTSQKSLSVKEVKSFTQIQATFC 1623

  Fly  1382 -------------------LLLRIESIQLTPSLENP-------LVRQLVRPDIYQKAAE---LNM 1417
                               :.|:.:..::..|.::|       .:..|:..|:.:|..:   .|:
Human  1624 ISELQVQLSGDLTLGAQGLVSLKFQDFEVEFSKDHPQTLSIQIALHSLLMEDLLEKNPDSKYKNL 1688

  Fly  1418 LSTPGA-----------------LVEDRQY------------------ELSVRRVSLSTGNWKQT 1447
            :.:.||                 .|.:.:|                  :|..|..|.|....|:.
Human  1689 MVSRGAPKPSSLAQKEYLSQSCPSVSNVEYPDMPRSLPSHMEEAPNVFQLYQRPTSASRKKQKEV 1753

  Fly  1448 Q--EYRIEKTLASKHDNPAFEWNNQSQSTELDHMEIF----KDFDFIMIYAPAISYDRFLVCGQS 1506
            |  :|.:....:...|.|............|.|:.||    |..:|      :.||:|   ..:|
Human  1754 QDKDYPLTPPPSPTVDEPKILVGKSKFDDSLVHINIFLVDKKHPEF------SSSYNR---VNRS 1809

  Fly  1507 --VEYNCATDFVASLNTHQISLISCIIVRAQRLGCIIDQVCVKNAELPKARSHKTLGNISKYNSV 1569
              |::|| .|.:.:|.|.      .:|:....:|...|...::..  |:...|..  .:..:.|:
Human  1810 IDVDFNC-LDVLITLQTW------VVILDFFGIGSTADNHAMRLP--PEGILHNV--KLEPHASM 1863

  Fly  1570 DNSIYFPA----DPKVFKKDTWIPKSSKKLVSERLSYTNA----------------STSFTDAKG 1614
            ::.:..|.    |.||......:.|::.:|....:|...|                |.|.:|...
Human  1864 ESGLQDPVNTKLDLKVHSLSLVLNKTTSELAKANVSKLVAHLEMIEGDLALQGSIGSLSLSDLTC 1928

  Fly  1615 SSDYF------------------YGS----CQSDSGIHLGTRMKG----YSRSLAAEEI------ 1647
            ..:::                  ||.    .:.:..|.:..||..    :::...||.:
Human  1929 HGEFYRERFTTSGEEALIFQTFKYGRPDPLLRREHDIRVSLRMASVQYVHTQRFQAEVVAFIQHF 1993

  Fly  1648 ----NRSGRQ---------------------------PFVLSYPSSVS---FVAGIFVLKI---- 1674
                :..|||                           |.:|...||.|   .||.:..||:
Human  1994 TQLQDVLGRQRAAIEGQTVRDQAQRCSRVLLDIEAGAPVLLIPESSRSNNLIVANLGKLKVKNKF 2058

  Fly  1675 ---------------------------YDVLELEELERP-------------------VMKPLFL 1693
                                       :.:.:....|.|                   .:|..|:
Human  2059 LFAGFPGTFSLQDKESVPSASPTGIPKHSLRKTTSTEEPRGTHSQGQFTMPLAGMSLGSLKSEFV 2123

  Fly  1694 MTVS------QPSFMSTQNFKAAVTQASIFNVNISVAKADVD-----------GKVDSERFNESV 1741
            .:.|      ||:....|...:......:.:. :.|...|:|           .|...:...:.:
Human  2124 PSTSTKQQGPQPTLSVGQESSSPEDHVCLLDC-VVVDLQDMDIFAAERHPREYSKAPEDSSGDLI 2187

  Fly  1742 FAT-LPGQLGSSGIPPPLLTIKTQYDRLHQKEV------------------DVELRKPILLR-IC 1786
            |.: ...|.|.|.:..| ..:|.|.:|...||:                  .::|.|..|:| :.
Human  2188 FPSYFVRQTGGSLLTEP-CRLKLQVERNLDKEISHTVPDISIHGNLSSVHCSLDLYKYKLIRGLL 2251

  Fly  1787 ENTIKQLASDVFRIYTVLHETPCFNVRSPR--PVPEGSQLRQLKMNCYNADRFHLSCDRITAKFY 1849
            ||.:.:...:..|.|         :::.||  .|..|        ..|....|.:....::.:..
Human  2252 ENNLGEPIEEFMRPY---------DLQDPRIHTVLSG--------EVYTCMCFLIDMVNVSLELK 2299

  Fly  1850 DEERS-----------YKCSFVWLDVSTRIKFSSRPQKAVIRSNIGSFYVQ-SGEKMLLHPLLMR 1902
            |.:|.           .||..::...|.:.|..:     ::..::.:|..: :|:|  ..|.:..
Human  2300 DPKRKEGAGSLARFDFKKCKLLYESFSNQTKSIN-----LVSHSMMAFDTRYAGQK--TSPGMTN 2357

  Fly  1903 LSVDLVSEPWSEELLVNATLKLNYLHI----DAGVFSILQLQKAQQGVNRIREYADREWQQFLRS 1963
            : ...:.:|.........::::. ||.    |:..|:::        :|.:|.:...:|  .|..
Human  2358 V-FSCIFQPAKNSSTTQGSIQIE-LHFRSTKDSSCFTVV--------LNNLRVFLIFDW--LLLV 2410

  Fly  1964 RPVLGTPKDVSPCNLIKCTPSHESIERIKRPLKSNAEFYQDDLRAGAFQFVYLNSESVLPMPYQV 2028
            ...|.||.|:...|.:  |||        |...|::|                  .:::|...:.
Human  2411 HDFLHTPSDIKKQNHV--TPS--------RHRNSSSE------------------SAIVPKTVKS 2447

  Fly  2029 QIIKKNYGIICWRYPQPRQMTSIHIYPVPMPVSRPIHIRCRMEYFSETHETFLHYCDFMLSETS- 2092
            .::.|...                     :|||...|:..::   :.|...|:...|....:|:
Human  2448 GVVTKRSS---------------------LPVSNERHLEVKV---NVTGTEFVVIEDVSCFDTNA 2488

  Fly  2093 -----TKQLT-PP---DRPICATIWRVVILQSLISVDGTCFEGSE-DEDLSI-EYLQSDFKVDEN 2146
                 |..|| .|   |||...:::.:.:.        :|..|:| |..||| :.:|...::..|
Human  2489 IILKGTTVLTYKPRFVDRPFSGSLFGIEVF--------SCRLGNEHDTALSIVDPVQIQMELVGN 2545

  Fly  2147 NDFILHPKVLVGCMRIDTVFRAEKVPK-LQLLLCCQDIELNFVNQTDNTGEL--------PKQLN 2202
            :.:    :...|.|   ..|.:|..|. |::.|...||.|::     |..:|        |:|.|
Human  2546 SSY----QNSSGLM---DAFNSEDFPPVLEIQLQALDIRLSY-----NDVQLFLAIAKSIPEQAN 2598

  Fly  2203 KYRLRQTPNITQ-------TFL-------------TVHVED--LQMHSRIYSRNDFSLQTEMRAR 2245
                ...|:...       |:|             |.|..|  |::.........||:....:|.
Human  2599 ----AAVPDSVALESDSVGTYLPGASRVGEEIREGTRHTLDPVLELQLARLQELGFSMDDCRKAL 2659

  Fly  2246 VKC-------LDYGFLNMLDVLEPMKFSSYVRLT-DYPRSLV----------------------- 2279
            :.|       ..:.|.|    .||:|..|....: |.|.::.
Human  2660 LACQGQLKKAASWLFKN----AEPLKSLSLASTSRDSPGAVAAPLISGVEIKAESVCICFIDDCM 2720

  Fly  2280 ------------QANFLVDKLRLNCGPH-VIHTLLSSKYH------WQEVL---------QQKDV 2316
                        :.|||   .|:...|. ..|..||..|:      |:..:         ||:..
Human  2721 DCDVPLAELTFSRLNFL---QRVRTSPEGYAHFTLSGDYYNRALSGWEPFIEPWPCSVSWQQQAA 2782

  Fly  2317 RHVLMPKLVIVNRIQTPISFGQTNTVEKIPVNPGEVQLYHFRSCSHVQELTFFITNPKTLLVD-- 2379
            ..:..|:|.:           :.....::.:|                     ||   ::|:|
Human  2783 SRLHPPRLKL-----------EAKAKPRLDIN---------------------IT---SVLIDQY 2812

  Fly  2380 -SSDSVHIALKFEDEEKIHNLRVGE------------------YCITLKLAKLSTTQIYILVKGQ 2425
             |:....:|...:|::.|.:.:..:                  |..|...|.|:..:..|..:.:
Human  2813 VSTKESWMADYCKDDKDIESAKSEDWMGSSVDPPCFGQSLPLVYLRTRSTASLTNLEHQIYARAE 2877

  Fly  2426 IELVS----MVPFNLVTEFREEEINYDE--------STPPEHLLLSKERS--------------- 2463
            ::...    .|||.|        .|:..        :|.|....||...|
Human  2878 VKTPKRRQPFVPFAL--------RNHTGCTLWFATLTTTPTRAALSHSGSPGVVPEGNGTFLDDT 2934

  Fly  2464 ---SYYQNVKRNADINMRLKLTAGLGRGRTGDIPLKTNNNLPWLVKVPTQSAQQFISIWVRILRE 2525
               |.::.|....:|....:....|....|.|:.:              ...|..::.|.::  .
Human  2935 HNVSEWREVLTGEEIPFEFEARGKLRHRHTHDLRI--------------HQLQVRVNGWEQV--S 2983

  Fly  2526 DIKMDKPAEDFQ------------------------PQKILICIWPIFEICNMLSCAVKATESTT 2566
            .:.:||....|:                        ||.....:.|           |:...:.|
Human  2984 PVSVDKVGTFFRYAAPDKNSSSSTIGSPSSRTNIIHPQVYFSSLPP-----------VRVVFAVT 3037

  Fly  2567 GESSTIEAMGGRWALNTATTHATEHNIGF----------TFSGILRGSSKDEYSLMLRTMDWH-- 2619
            .|.|..:.:..|.||.......|...:..          ....|:.|   |.:::.|....|.
Human  3038 MEGSARKVITVRSALIVRNRLETPMELRLDSPSAPDKPVVLPAIMPG---DSFAVPLHLTSWRLQ 3099

  Fly  2620 -------KFFYYDPTVWTIENALHKLG-KSSKRKWPLNDPEELRVSR---VLDFENAFDVK---- 2669
                   .||...|..||  |.:.... .||||:....|.|:.|..|   .:..||..|..
Human  3100 ARPKGLGVFFCKAPIHWT--NVVKTAEISSSKRECHSMDTEKSRFFRFCVAIKKENYPDYMPSNI 3162

  Fly  2670 YQTKATREFS--------------C----CQGLDVTAWGMFINGT---GLYVAIFMIQEQARLDL 2713
            :...|.:.|.              |    |: ||....||.||||   |...|:........::|
Human  3163 FSDSAKQIFRQPGHTIYLLPTVVICNLLPCE-LDFYVKGMPINGTLKPGKEAALHTADTSQNIEL 3226

  Fly  2714 KANSLQMMPKLKSAFTIDVRFDNGWKSSTPICLEDFTQKSSSNAGRSLYLRYNSFVDIVIVERDE 2778
                             .|..:|     .|:|.|......:.|     |:......|:...:.:.
Human  3227 -----------------GVSLEN-----FPLCKELLIPPGTQN-----YMVRMRLYDVNRRQLNL 3264

  Fly  2779 VLRLILEYRQEDDGRRLFKLRSKFVFTNFTDVVLNALTLAMDHKENSTREEVEAYSICKKARSLV 2843
            .:|::.   :.:...::| :.:.:...|.|.:   .|....|:.:.....:.|.:.:.:....|:
Human  3265 TIRIVC---RAEGSLKIF-ISAPYWLINKTGL---PLIFRQDNAKTDAAGQFEEHELARSLSPLL 3322

  Fly  2844 SSESTKN---------------------CSGNAMDVFYDLNAHKA-KHNCDTAFVYFVCFSV--G 2884
            ...:.|.                     |.|.::|....:.|.|. :.......:|.:...|  |
Human  3323 FCYADKEQPNLCTMRIGRGIHPEGMPGWCQGFSLDGGSGVRALKVIQQGNRPGLIYNIGIDVKKG 3387

  Fly  2885 GSREISIPIPLAVP-------------FTRRCFSL---QAGPE----SIP--------------- 2914
            ..|.|...:.:..|             |.:|.|:.   .|.||    ::|
Human  3388 RGRYIDTCMVIFAPRYLLDNKSSHKLAFAQREFARGQGTANPEGYISTLPGSSVVFHWPRNDYDQ 3452

  Fly  2915 -LMITL-------------IEKDNVHYLNV------------------------FRDT---APAI 2938
             |.:.|             :.|:|..::|:                        |.||   .|..
Human  3453 LLCVRLMDVPNCIWSGGFEVNKNNSFHINMRDTLGKCFFLRVEITLRGATYRISFSDTDQLPPPF 3517

  Fly  2939 VISNNTNVKFIVAQTSASENSNVSCTNSEFVGRNFEWNQLVLP-------------HSNCYYTPP 2990
            .|.|.:.|..:..|...:| ..:..........::.|::..||             ..||.....
Human  3518 RIDNFSKVPVVFTQHGVAE-PRLRTEVKPMTSLDYAWDEPTLPPFITLTVKGAGSSEINCNMNDF 3581

  Fly  2991 Q-----MYANFPDVEFTMCNLSLAVYKDKLCAKNK-------------------IAWSKPIRTDK 3031
            |     .|.||..:..|.....|.....:..|.||                   :...:|.:..:
Human  3582 QDNRQLYYENFIYIAATYTFSGLQEGTGRPVASNKAITCAELVLDVSPKTQRVILKKKEPGKRSQ 3646

  Fly  3032 SWQ-----KFLH----VPHHGDVKVVVCDKHRAIRLNIYYIAQQLEFSVKDLRSR---LTKP--- 3081
            .|:     ...|    |||:.:..........:..|:|..:|     :|.|.|..   |.||
Human  3647 LWRMTGTGMLAHEGSSVPHNPNKPSAARSTEGSAILDIAGLA-----AVTDNRYEPLMLRKPDRR 3706

  Fly  3082 ------------------------------------ENVLMP--SQEQAAPRPDESSEQENDTK- 3107
                                                |.||.|  |.|...|.|.|  :|..:.|
Human  3707 RSTTQTWSFREGKLTCGLHGLVVQAKGGLSGLFDGAEVVLGPDTSMELLGPVPPE--QQFINQKM 3769

  Fly  3108 ---------RVTLPNMVTCAHFNEECESK------------------------TQTRIKIFIK-S 3138
                     ||............:.|..|                        |:..:::.:: .
Human  3770 RPGSGMLSIRVIPDGPTRALQITDFCHRKSSRSYEVDELPVTEQELQKLKNPDTEQELEVLVRLE 3834

  Fly  3139 FVFSLQTDNR---ENDFVKTEVCNIYADDSMLIYDDDDDQRELRLQLPNLQVDNQLYSSGKYDFP 3200
            ....|...|:   |..|......|::       |........|.|.:.::||||||..:.:   |
Human  3835 GGIGLSLINKVPEELVFASLTGINVH-------YTQLATSHMLELSIQDVQVDNQLIGTTQ---P 3889

  Fly  3201 VLLCAEKLYRRN-------------CSLPQVYDLDHVYKQ---QAQRTPVSLFTFIFYQDEMQLQ 3249
            .:|....|...|             ...|....|.::||.   .|||
Human  3890 FMLYVTPLSNENEVIETGPAVQVNAVKFPSKSALTNIYKHLMITAQR------------------ 3936

  Fly  3250 NVRCQIPPFRVYIEDAYLNQLL--------EALVECEPSNCVYSPPVEQDQILLPAGMTLLPDQV 3306
                    |.|.||:..|.:||        |:.||....| ::....||       |.|  |.:.
Human  3937 --------FTVQIEEKLLLKLLSFFGYDQAESEVEKYDEN-LHEKTAEQ-------GGT--PIRY 3983

  Fly  3307 VAQSLYISEP-LRLNSFTVEPLNLLLSVHTSSRLY---------IALDHSPLSFSR---YERQQI 3358
            ..::|.||.| ::|:.||...|.|.|....|:..:         |.||    .|:|   ||.::.
Human  3984 YFENLKISIPQIKLSVFTSNKLPLDLKALKSTLGFPLIRFEDAVINLD----PFTRVHPYETKEF 4044

  Fly  3359 LTVPLRFGQSLGLHYLSGAIFGAGWVVGSLEILGSPSGLARSFSTGLRDFVSMPVQGLFRGPWGF 3423
            :.      ..:..|:....:..|..::||::.||:|.||....|.|        |.||.:  :|.
Human  4045 II------NDILKHFQEELLSQAARILGSVDFLGNPMGLLNDVSEG--------VTGLIK--YGN 4093

  Fly  3424 LVGVTQGSASLLRNVTAGTVNSVTKLAGSVARNLDRLTLDAEH-IELTEARRRARPQGFADGLTQ 3487
            :.|       |:||||.|..||..|.||:::..|.: |:|..| .|....|..|...|  :.|..
Human  4094 VGG-------LIRNVTHGVSNSAAKFAGTLSDGLGK-TMDNRHQSEREYIRYHAATSG--EHLVA 4148

  Fly  3488 GLTGLGISLLGAVGGLAHHTLEARSS----VGVIAGLTKGIVGALTKPISGAAEMLALTGQGVLH 3548
            |:.||...::|.:..:...|:|...:    .|.|:||.||:||.:|||::||.:..:.|.|.|..
Human  4149 GIHGLAHGIIGGLTSVITSTVEGVKTEGGVSGFISGLGKGLVGTVTKPVAGALDFASETAQAVRD 4213

  Fly  3549 TVGFNAMPQQVE 3560
            |...:....|.:
Human  4214 TATLSGPRTQAQ 4225

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps13B	NP_651753.2	Chorein_N	5..117	CDD:289396	32/114 (28%)
		VPS13_C	3319..3468	CDD:293514	45/161 (28%)
		ATG_C	3473..3546	CDD:286423	25/76 (33%)
VPS13D	NP_056193.2	Chorein_N	3..112	CDD:289396	31/111 (28%)
		VPS13	139..356	CDD:293513	37/231 (16%)
		VPS13_mid_rpt	614..894	CDD:293515	61/302 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	745..796		12/50 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1563..1582		8/18 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1741..1771		7/29 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2070..2108		2/37 (5%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2122..2145		5/22 (23%)
		UBA_VP13D	2642..2677	CDD:270491	6/38 (16%)
		SHR-BD	3276..3559	CDD:284143	41/287 (14%)
		VPS13_C	3984..4129	CDD:293514	48/172 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5043
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1642
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.930