DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps13B and VPS13C

DIOPT Version :9

Sequence 1:	NP_651753.2	Gene:	Vps13B / 43550	FlyBaseID:	FBgn0039727	Length:	3731	Species:	Drosophila melanogaster
Sequence 2:	NP_065872.1	Gene:	VPS13C / 54832	HGNCID:	23594	Length:	3753	Species:	Homo sapiens

Alignment Length:	4555	Identity:	797/4555 - (17%)
Similarity:	1465/4555 - (32%)	Gaps:	1704/4555 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LESYITPILLSYVAKYVKNFRDEDAQVSLWEGEVTFQNLDLRLEVLEEELNLPVELVSGHIHELS 68
            |||.:..:|..::..||:|......::.:|.|.|...||.::...| .||::|.::.:|.|.:|:
Human     3 LESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENAL-SELDVPFKVKAGQIDKLT 66

  Fly    69 ILVPWTKLMSEPVKIVINTIE--FVAKLPDS--------------ESKQRRASFQRE-------- 109
            :.:||..|..|   .|:.|:|  ::..:|.:              :.||:..|...|
Human    67 LKIPWKNLYGE---AVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEEALQKAAEK 128

  Fly   110 ----------------------QRRKSKRESVEQP----DQTK-SPGPASSSSVVNK----IINN 143
                                  ::||..::..::|    |::| .|..|...:.|.|    :|.|
Human   129 GTHSGEFIYGLENFVYKDIKPGRKRKKHKKHFKKPFKGLDRSKDKPKEAKKDTFVEKLATQVIKN 193

  Fly   144 INLQCHNIILKYVEDDIV-------VSMNVQTLNFSSAGEDWKPTMVDIHPVSVVMRKLLQVSDL 201
            :.::..:|.:|| |||:.       ..:.:..|:..:|.|.|.|.:  ::....::.||:::..|
Human   194 VQVKITDIHIKY-EDDVTDPKRPLSFGVTLGELSLLTANEHWTPCI--LNEADKIIYKLIRLDSL 255

  Fly   202 TI-----C-----------LDK-RN---TAGRIEVCQEPVLYRCTLECRVLRKYNANTVSTTSTT 246
            :.     |           ||: :|   |:|.|     |..|          :|....:|.::..
Human   256 SAYWNVNCSMSYQRSREQILDQLKNEILTSGNI-----PPNY----------QYIFQPISASAKL 305

  Fly   247 RIGVFTKS------LDINVS------SLQFPMVMRLVKMLLELKPAEFEDDPQNPEDQEAVAEGS 299
            .:..:.:|      ||.|:.      .|..|..:.::.:|
Human   306 YMNPYAESELKTPKLDCNIEIQNIAIELTKPQYLSMIDLL------------------------- 345

  Fly   300 ESQQGTESAGRSVFWWAWSLLPSFDTEAPSSSCDTPTGHAFDLGVYAEELNFQLKNSEYFTDQSM 364
                                                           |.:::.::|:.|
Human   346 -----------------------------------------------ESVDYMVRNAPY------ 357

  Fly   365 GGIKRIRYTPILRISLGGL------------YYERTILKECDWANVKAGLSSMCMEPLGAYRSDD 417
                 .:|.|.|.:...|.            .:.|...:...|:|:|..     .:.|.:|:
Human   358 -----RKYKPYLPLHTNGRRWWKYAIDSVLEVHIRRYTQMWSWSNIKKH-----RQLLKSYK--- 409

  Fly   418 LVDRNLVN----TQEFQQERSFIDKSLFDENYMFAER-------------------------SWC 453
            :..:|.:.    ::|.|:|...::|:|...|.:.|.:                         .|.
Human   410 IAYKNKLTQSKVSEEIQKEIQDLEKTLDVFNIILARQQAQVEVIRSGQKLRKKSADTGEKRGGWF 474

  Fly   454 SYNYADYVARNTDEYMLFRSPVLAFDVIEHRVPKPSSHPVAESQLRDLGVRIQYRLLSAGITFHF 518
            |..:....::..||              |..:|:.....:...:...|...|.|...:..:|.
Human   475 SGLWGKKESKKKDE--------------ESLIPETIDDLMTPEEKDKLFTAIGYSESTHNLTL-- 523

  Fly   519 SQSFVQVKKVISDLIRPYDYPGYRSESMKDEDRGVPEPENKNSEMTIPDLEYLMGLVPTCNYKIE 583
                  .|:.::.::           ::|.....|...||||    ||::           .||:
Human   524 ------PKQYVAHIM-----------TLKLVSTSVTIRENKN----IPEI-----------LKIQ 556

  Fly   584 LRNIVVQL--YPRQQQDESSAINQHQLTTTVR-QSLLPYL----------QLKISLVEGTMCGPV 635
            :..:..|:  .|..|..:..|..:|...|.:| |.::|.|          .|||.........|.
Human   557 IIGLGTQVSQRPGAQALKVEAKLEHWYITGLRQQDIVPSLVASIGDTTSSLLKIKFETNPEDSPA 621

  Fly   636 NPVRLVQLITHLEEKPRDV------VNACYNCFHFN-------VKNLALMIMNTTPDNGRAKLLN 687
            :...:||      .:|.:|      |||....|..|       :.:..||.:....:.....|.:
Human   622 DQTLIVQ------SQPVEVIYDAKTVNAVVEFFQSNKGLDLEQITSATLMKLEEIKERTATGLTH 680

  Fly   688 I--------PRVQVNWNRLLAPHLWRQNEAPLETSEIKSEIITLEFSKRELIIAKRLVPLISSFS 744
            |        .|:.:..:.|:.|.....:|        ||:::.|:|...:|....:.:...::.|
Human   681 IIETRKVLDLRINLKPSYLVVPQTGFHHE--------KSDLLILDFGTFQLNSKDQGLQKTTNSS 737

  Fly   745 GQDLCDLAHIVANVNVNSDVIKLQSVGTKLNLVYHKYHTHLAAVGSLQGVHTDAVHTKMNIRNVV 809
            .:::.|.|                         |.|:                    .:.|:||.
Human   738 LEEIMDKA-------------------------YDKF--------------------DVEIKNVQ 757

  Fly   810 LSTSKNADNKWLEMQCQFPLE-------EVHSEQEKIPGTVVCLWLEPFRITTDIYLLQF----- 862
            |..:: |:..|.:.:.|.|..       ::|.|..|.            .:..||.:.:|
Human   758 LLFAR-AEETWKKCRFQHPSTMHILQPMDIHVELAKA------------MVEKDIRMARFKVSGG 809

  Fly   863 -----LNFSDNSGRQITKDKEVETDLESVNQSEPPITQSVSNYSTISASAIAFNDFQPRRISRNN 922
                 :..||.      |.|:|...:.|:     |:.|..|..|
Human   810 LPLMHVRISDQ------KMKDVLYLMNSI-----PLPQKSSAQS--------------------- 842

  Fly   923 SRKISVPEETVHLSSERDERHTQAEPLTIPVANKPQPSNFDTTDFVKRLTKMVVLVEIAQAKIDV 987
                  ||..|.               :||:          .:...|.|....:|::..:::
Human   843 ------PERQVS---------------SIPI----------ISGGTKGLLGTSLLLDTVESE--- 873

  Fly   988 CEVMMRKTPGHTDVEYTSIRLPHMKVKSG---NCEAIQRGNIRGVIPVASNTELLNWV--FDLNE 1047
                       :|.||       ...:.|   .|::::...::....| .|.||:|.:  |::.|
Human   874 -----------SDDEY-------FDAEDGEPQTCKSMKGSELKKAAEV-PNEELINLLLKFEIKE 919

  Fly  1048 FNVCYRRA----------NVTEM-IIAPVRTTITLALSF--KTS---DKVDGSKGKEDKCANTCS 1096
            ..:.:.:.          |||:: ..|.:||.....:|:  |.|   .:::|||.|.
Human   920 VILEFTKQQKEEDTILVFNVTQLGTEATMRTFDLTVVSYLKKISLDYHEIEGSKRKP-------- 976

  Fly  1097 INVHVDMSAINIFAQRVKLLHEHCLIISKMYGSLCPDEPASKWQT--GKMKPRLEVYTGSAQNYP 1159
              :|:..|:.......:|:.:            :..|:....:||  ||.:..::| ..|:.|..
Human   977 --LHLISSSDKPGLDLLKVEY------------IKADKNGPSFQTAFGKTEQTVKV-AFSSLNLL 1026

  Fly  1160 VIKEFLELDPNFEAPKVKSAPKS-SVILFCQWTIPRISFEMENSNDFKHSKIVMSLEDLLLNIDK 1223
            :..:.|....|:....:.|..:| ||....|     ||.|.:..|......||.|.:..::
Human  1027 LQTQALVASINYLTTIIPSDDQSISVAKEVQ-----ISTEKQQKNSTLPKAIVSSRDSDII---- 1082

  Fly  1224 HSDFNKITTKIENFGLNYYEEKHEEWEKIDDLHIKMLGDSTNLP---------LISVVITTVSLE 1279
              || ::..|:..|.:....||:    .|.::.|:.|..|.:|.         |.::::|.|..:
Human  1083 --DF-RLFAKLNAFCVIVCNEKN----NIAEIKIQGLDSSLSLQSRKQSLFARLENIIVTDVDPK 1140

  Fly  1280 -------------------DLYAKIGARNPHNKQHTISEVLIEVQPIEMVLNLD----QITEFMV 1321
                               |||          ...|..::..::..::.||:|:    ||.....
Human  1141 TVHKKAVSIMGNEVFRFNLDLY----------PDATEGDLYTDMSKVDGVLSLNVGCIQIVYLHK 1195

  Fly  1322 PICEVLEIIGN---------SASAQSANKPSAPVPSKITTVQDLPM------VHLNSKGIYVYLP 1371
            .:..:|..:.|         :|:||:|.:.:       |:|:||..      ::::.|...:.:|
Human  1196 FLMSLLNFLNNFQTAKESLSAATAQAAERAA-------TSVKDLAQRSFRVSINIDLKAPVIVIP 1253

  Fly  1372 ---LSTGKKSCSVLLLRIES--------------------IQLTPSLENPLVRQLVRPDIYQKAA 1413
               :||......:.|:|:.:                    :|||   :..|.|.:::|.||....
Human  1254 QSSISTNAVVVDLGLIRVHNQFSLVSDEDYLNPPVIDRMDVQLT---KLTLYRTVIQPGIYHPDI 1315

  Fly  1414 ELNMLSTPGALVEDRQYELSVRRVSLSTGNWKQTQEYRIEKTLASK--HDNPAFEWNNQSQSTEL 1476
            :|                  :..::|         |:.:.:.||:.  |..|..|...     .|
Human  1316 QL------------------LHPINL---------EFLVNRNLAASWYHKVPVVEIKG-----HL 1348

  Fly  1477 DHMEIFKDFDFIMIYAPAISYDRFLVCGQSVEYNCATDFVASLNTHQISLISCIIV--------- 1532
            |.|.:                                    |||...::|:..|:.
Human  1349 DSMNV------------------------------------SLNQEDLNLLFRILTENLCEGTED 1377

  Fly  1533 ------RAQRLGCIIDQVCVK-NAELPKARSHKTLGNISKYNSVD--NSIY-FPADPKVFKKDTW 1587
                  |.|..|.|.:.:.:. :.::..:::..|.| :.:..|||  |.:. |.....|.   |.
Human  1378 LDKVKPRVQETGEIKEPLEISISQDVHDSKNTLTTG-VEEIRSVDIINMLLNFEIKEVVV---TL 1438

  Fly  1588 IPKSSKK-----------LVSERLSYTNASTS-------------FTDAKGSSDYFYGSCQ-SDS 1627
            :.||.||           |..|....|...|:             |||:||...:...|.. :|.
Human  1439 MKKSEKKGRPLHELNVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFTDSKGEPLHIINSSNVTDE 1503

  Fly  1628 GIHLGTRMKGYSRSLAAEEINRSGRQPFVLSYPSSVSFVAGIFVLKIYDVLELEEL--------- 1683
            .:......|..|.....:.|:.|.:|...:|:.|          |.:  ||.||.|
Human  1504 PLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFAS----------LDL--VLHLEALLSFMDFLSS 1556

  Fly  1684 -----------ERPVMKPLFLMTVSQPSFMSTQNFKAAVTQASIFNVNISVAK------------ 1725
                       :...:|||    |.:...::.:...:.::|..:|::.|:...
Human  1557 AAPFSEPSSSEKESELKPL----VGESRSIAVKAVSSNISQKDVFDLKITAELNAFNVFVCDQKC 1617

  Fly  1726 --ADV-----DGKVDSERFNESVFATLPGQLGSSGIPPPLLTIKTQYDRLHQKEVDVELRKPILL 1783
              ||:     |..:..:.....|||.|          ..::.:......:|:|.|.:
Human  1618 NIADIKIHGMDASISVKPKQTDVFARL----------KDIIVMNVDLQSIHKKAVSI-------- 1664

  Fly  1784 RICENTIKQLASDVFRIYTVLHETPCFNVRSPRPVPEGSQLRQL---------KMNCYN---ADR 1836
                     |..:|||....|:.          ...||.....:         |:.|..   ..:
Human  1665 ---------LGDEVFRFQLTLYP----------DATEGEAYADMSKVDGKLSFKVGCIQIVYVHK 1710

  Fly  1837 FHLS----------------------CDRITAKFYD-EERSYKCSFVWLDVSTRIKFSSRPQKAV 1878
            |.:|                      .:|..:...| .::|::   :.:|::.:......||.:|
Human  1711 FFMSLLNFLNNFQTAKEALSTATVQAAERAASSMKDLAQKSFR---LLMDINLKAPVIIIPQSSV 1772

  Fly  1879 ----IRSNIGSFYVQSG------EKMLLHPLLMRLSVDLVSEPWSEELLVNATLKLNYLHIDAGV 1933
                :.:::|...|::.      |...|.|::.:::::|.....|..:| .|:|..|.:.|...|
Human  1773 SPNAVIADLGLIRVENKFSLVPMEHYSLPPVIDKMNIELTQLKLSRTIL-QASLPQNDIEILKPV 1836

  Fly  1934 FSILQLQKAQQGVNRIREYADREWQQFLRSRPVLGTPKDVSPCNLIKCTPSHESIERIKRPLK-S 1997
            ..:|.:|         |..|...:.|.                      |..|    ||..|| .
Human  1837 NMLLSIQ---------RNLAAAWYVQI----------------------PGME----IKGKLKPM 1866

  Fly  1998 NAEFYQDDLRAGAFQFVYLNSESVLPMPYQVQIIKKNYGIICWRYPQPRQ--MTSIHIYPVPMPV 2060
            .....:|||             :||     ::|:.:|.|... ..|.|.|  ..::.:..|.:.
Human  1867 QVALSEDDL-------------TVL-----MKILLENLGEAS-SQPSPTQSVQETVRVRKVDVS- 1911

  Fly  2061 SRPIHIR-----------------CRMEYFSETHETFL-------------HYCDFMLSETSTKQ 2095
            |.|.|::                 .:.::..|:....|             |...|.|.|.....
Human  1912 SVPDHLKEQEDWTDSKLSMNQIVSLQFDFHFESLSIILYNNDINQESGVAFHNDSFQLGELRLHL 1976

  Fly  2096 LTPPDRPICATIWRVVILQSLISVDGTCFEGSE-----------DEDLSIEYLQSDFKVDENNDF 2149
            :....:........|.:.....::| ...||.|           |:|.:...:...:|.|:|..
Human  1977 MASSGKMFKDGSMNVSVKLKTCTLD-DLREGIERATSRMIDRKNDQDNNSSMIDISYKQDKNGS- 2039

  Fly  2150 ILHPKVLVGCMRIDTVFRAEKVPKLQLLLCCQDIELNFV--------------NQTDNTGELPKQ 2200
                       :||.|        |..|..|..:|....              |....|..||:|
Human  2040 -----------QIDAV--------LDKLYVCASVEFLMTVADFFIKAVPQSPENVAKETQILPRQ 2085

  Fly  2201 --LNKYRLRQ----TPNITQTFLTVHVEDLQMHSRI--------------YSRNDFSLQTEMRAR 2245
              ..|.::.:    .||:|...:....|.:.:.|..              .|.:...|:..|.|.
Human  2086 TATGKVKIEKDDSVRPNMTLKAMITDPEVVFVASLTKADAPALTASFQCNLSLSTSKLEQMMEAS 2150

  Fly  2246 V---KCLDYGFL------NMLDVLEPMKFSSYVRLTDYPRSLVQANFLVDKLRLNCGPHVIHTLL 2301
            |   |.|...||      |:..||:|.  |.::....:.......|.:|.:..:...|.:::|:|
Human  2151 VRDLKVLACPFLREKRGKNITTVLQPC--SLFMEKCTWASGKQNINIMVKEFIIKISPIILNTVL 2213

  Fly  2302 S------------------------------SKYH-W-------QEVLQQ-KDVRHVLMPKL--V 2325
            :                              :.|: |       .|:.:. |.:.|.|:.:.  |
Human  2214 TIMAALSPKTKEDGSKDTSKEMENLWGIKSINDYNTWFLGVDTATEITESFKGIEHSLIEENCGV 2278

  Fly  2326 IVNRIQTPISFGQTNTVEKIPVNPGE---------------------VQLYHFRSCSHVQE---- 2365
            :|..||..:..|..:  ..:|:...|                     :|::::.....|.|
Human  2279 VVESIQVTLECGLGH--RTVPLLLAESKFSGNIKNWTSLMAAVADVTLQVHYYNEIHAVWEPLIE 2341

  Fly  2366 ---------LTFFI-TNP---KTLLVDSSDSVHIALKFEDEEKIH-------NLRVGEYCITL-- 2408
                     |...: .||   |:|| ...|.:.     |.:..||       |:.:.:.|:.:
Human  2342 RVEGKRQWNLRLDVKKNPVQDKSLL-PGDDFIP-----EPQMAIHISSGNTMNITISKSCLNVFN 2400

  Fly  2409 KLAK-----LSTTQIYIL-------VKGQIELVSMVPFNL---VTEFREE------------EIN 2446
            .|||     .::|..|.|       ||..:.:...|..|.   |..|.|:            |:.
Human  2401 NLAKGFSEGTASTFDYSLKDRAPFTVKNAVGVPIKVKPNCNLRVMGFPEKSDIFDVDAGQNLELE 2465

  Fly  2447 YDESTPPEH---LLLSKERSSYY-----------------------------QNVKRNADINMRL 2479
            |....|...   .:||::.||::                             .|...:..:.:::
Human  2466 YASMVPSSQGNLSILSRQESSFFTLTIVPHGYTEVANIPVARPGRRLYNVRNPNASHSDSVLVQI 2530

  Fly  2480 KLTAGLGRGRTGDIPLKTNN--NLPWLVKVPTQSAQQFISIWVRILREDIKMDKPAEDF------ 2536
            ..|.| .:..|...||:..|  ::.:::       .:|:.. |::| |.|.:.:|.|:|
Human  2531 DATEG-NKVITLRSPLQIKNHFSIAFII-------YKFVKN-VKLL-ERIGIARPEEEFHVPLDS 2585

  Fly  2537 -------QPQKIL---------ICIWP-----IFEICNMLSC---------AVKATESTTGESST 2571
                   ||..||         ...|.     ..|:..||.|         .:..|.:...|.|.
Human  2586 YRCQLFIQPAGILEHQYKESTTYISWKEELHRSREVRCMLQCPSVEVSFLPLIVNTVALPDELSY 2650

  Fly  2572 IEAMGGRWALNTATTHATEHNIGF--------TFSGILRGSSKDEYSLMLRTMDWHKFFYYDPTV 2628
            |            .||..:.::.:        |...:|      .|||.         :..:.|.
Human  2651 I------------CTHGEDWDVAYIIHLYPSLTLRNLL------PYSLR---------YLLEGTA 2688

  Fly  2629 WTIENALHKLGKSSKRKWPLNDPEELRVSRVLDFENAFDVKYQTKATREFSCCQGLDVTAWGMFI 2693
            .|     |:|.:.|..     |....|:|.  :......||||.|              .|
Human  2689 ET-----HELAEGSTA-----DVLHSRISG--EIMELVLVKYQGK--------------NW---- 2723

  Fly  2694 NGTGLYVAIFMIQEQARLDLKANSLQMMPKLKSAFTIDVRFDNGWKSSTPICLEDFTQKSSSNAG 2758
            ||.      |.|::            .:|:.     ..|.|.:.....|.:.|....::..|...
Human  2724 NGH------FRIRD------------TLPEF-----FPVCFSSDSTEVTTVDLSVHVRRIGSRMV 2765

  Fly  2759 RSLYLRYNSFVDIVIVERDEVLRLILEYRQED-------DGRR--LFKLRSKFVFTNFTDVVLNA 2814
            .|::..|      .::.:   ...:|:||.||       |.|.  ||..:.|.:||.      |.
Human  2766 LSVFSPY------WLINK---TTRVLQYRSEDIHVKHPADFRDIILFSFKKKNIFTK------NK 2815

  Fly  2815 LTLAMDHKENSTREEVEAYSICKKARSLVSSESTKNCSGNAMDVFYDLNAHKAKHNCDTAFVYFV 2879
            :.|.:     ||.....::|:     ..|.|.....|..|.|:....::...:..|.
Human  2816 VQLKI-----STSAWSSSFSL-----DTVGSYGCVKCPANNMEYLVGVSIKMSSFNL-------- 2862

  Fly  2880 CFSVGGSREISIPIPLAVPFTRRCFSLQAG-------------------------PESI--PLMI 2917
                  ||.::: .|......:....|:.|                         |||:  .|.:
Human  2863 ------SRIVTL-TPFCTIANKSSLELEVGEIASDGSMPTNKWNYIASSECLPFWPESLSGKLCV 2920

  Fly  2918 TLI------------EKDNVHYLNVFRDTAPAIVISNNTNVKFIVAQTSASENSNVSCTNSEF-- 2968
            .::            .:||...|:: .|....|::..||           :|:|.| .|.|::
Human  2921 RVVGCEGSSKPFFYNRQDNGTLLSL-EDLNGGILVDVNT-----------AEHSTV-ITFSDYHE 2972

  Fly  2969 ------VGRNFEWNQLVLPHSNCYYTPPQMYANFPDVEFTMCNLSLAVYKDKLCAKNKIAWSKPI 3027
                  :..:..|:.|....|.   :|.:|.              |...:.:|     .||:.|.
Human  2973 GSAPALIMNHTPWDILTYKQSG---SPEEMV--------------LLPRQARL-----FAWADPT 3015

  Fly  3028 RTDK-SWQKFLHVPHHGDVKVVVCDKHRAIRLNIYYIAQQLEFSVKDLRSR-LTKPENVLMPSQE 3090
            .|.| :|....:|..|..:|...........:.|:::      |..|.|.| |...::|.:.|:.
Human  3016 GTRKLTWTYAANVGEHDLLKDGCGQFPYDANIQIHWV------SFLDGRQRVLLFTDDVALVSKA 3074

  Fly  3091 QAAPRPDESSEQ-------------ENDTKR------VTLPNMVTCAHFNEECESKTQTRIKIFI 3136
            ..|...:::..:             .|::|:      :|...:|        .|.|.:.:.|.|.
Human  3075 LQAEEMEQADYEITLSLHSLGLSLVNNESKQEVSYIGITSSGVV--------WEVKPKQKWKPFS 3131

  Fly  3137 KSFVFSLQTDNR-------------ENDF--------------VKTEVCNIYADDSMLIYDDDDD 3174
            :..:..|:...:             :|:|              :::.:...:.....:.:.....
Human  3132 QKQIILLEQSYQKHQISRDHGWIKLDNNFEVNFDKDPMEMRLPIRSPIKRDFLSGIQIEFKQSSH 3196

  Fly  3175 QRELRLQLPNLQVDNQLYSSGKYDFPVLLCAEKLYRRNCSLPQVYDLDHVYKQQAQRTP---VSL 3236
            ||.||.:|..|||||||..:   .|||:.       ...:.|:...||      ::..|   ||:
Human  3197 QRSLRARLYWLQVDNQLPGA---MFPVVF-------HPVAPPKSIALD------SEPKPFIDVSV 3245

  Fly  3237 FT-FIFYQDEMQLQNVRCQIPPFRVYIEDAYLNQLLEALVECEPSNCVYSPP------------V 3288
            .| |..|...:|.:.....|....:.|:..:|..::          .:::|.            :
Human  3246 ITRFNEYSKVLQFKYFMVLIQEMALKIDQGFLGAII----------ALFTPTTDPEAERRRTKLI 3300

  Fly  3289 EQDQILLPAGM--TLLPDQVVA---QSLYISEPLRLN------------------SFTVEPLNLL 3330
            :||...|.|.:  |.:.|..:.   :..:|| |::|:                  .|.|..:|||
Human  3301 QQDIDALNAELMETSMTDMSILSFFEHFHIS-PVKLHLSLSLGSGGEESDKEKQEMFAVHSVNLL 3364

  Fly  3331 L-----SVHTSSRLYIALDHSPLSFSRYERQQILTVPLRFGQSLGLHYLSGAIFGAGWVVGSLEI 3390
            |     ::.....|...|.:..:.:..|:|.|::...:|       ||....:.....:|..|::
Human  3365 LKSIGATLTDVDDLIFKLAYYEIRYQFYKRDQLIWSVVR-------HYSEQFLKQMYVLVLGLDV 3422

  Fly  3391 LGSPSGLARSFSTGLRDFVSMPVQGLFRGPWGFLVGVTQGSASLLRNVTAGTVNSVTKLAGSVAR 3455
            ||:|.||.|..|.|:......|.||..:||..|..|:..|..||..:...|....|:::.|||.:
Human  3423 LGNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSRITGSVGK 3487

  Fly  3456 NLDRLTLDAEHIELTEARRRARPQGFADGLTQGLTGLGISLLGAVGGLAHHTLEA---RSSVGVI 3517
            .|..:|:|.|:.:........:|:.|.|.|.:|..|....::|.|.|:....:|.   ..:.|..
Human  3488 GLAAITMDKEYQQKRREELSRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPVEGAKKEGAAGFF 3552

  Fly  3518 AGLTKGIVGALTKPISGAAEMLALTGQGV------------------LHTVGFNAMP---QQVEP 3561
            .|:.||:|||:.:|..|..:|.:.|.||:                  :|..|. ..|   |:.|.
Human  3553 KGIGKGLVGAVARPTGGIVDMASSTFQGIQRAAESTEEVSSLRPPRLIHEDGI-IRPYDRQESEG 3616

  Fly  3562 S-FIRN--VALHGSSNRIWSYLPEELSRDQMLFFSEIMLQISTQLRPALLFLTSSVLAIM----Q 3619
            | .:.|  ..|.|.:.|....:|..         .:.:|.::.  |..|......:|.:|    |
Human  3617 SDLLENHIKKLEGETYRYHCAIPGS---------KKTILMVTN--RRVLCIKEVEILGLMCVDWQ 3670

  Fly  3620 SDSEDLAFASPIS----KVDV----LADREDPS------KLYL--SLKSERRDDF--EGQLNYTN 3666
            ...||..|...:|    |:.|    |..::|.:      |:||  :..:||..:.  :.|.....
Human  3671 CPFEDFVFPPSVSENVLKISVKEQGLFHKKDSANQGCVRKVYLKDTATAERACNAIEDAQSTRQQ 3735

  Fly  3667 ERIMK 3671
            :::||
Human  3736 QKLMK 3740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps13B	NP_651753.2	Chorein_N	5..117	CDD:289396	32/157 (20%)
		VPS13_C	3319..3468	CDD:293514	44/171 (26%)
		ATG_C	3473..3546	CDD:286423	22/75 (29%)
VPS13C	NP_065872.1	Chorein_N	4..113	CDD:289396	27/112 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..176		6/25 (24%)
		VPS13	185..413	CDD:293513	48/336 (14%)
		VPS13_mid_rpt	613..833	CDD:293515	48/302 (16%)
		MRS6	1046..>2612	CDD:227376	309/1826 (17%)
		VPS13_mid_rpt	<1238..1368	CDD:293515	30/200 (15%)
		VPS13_mid_rpt	1690..1882	CDD:293515	40/248 (16%)
		SHR-BD	2764..3016	CDD:284143	56/326 (17%)
		WWE	3116..3181	CDD:295449	8/72 (11%)
		VPS13_C	3323..3500	CDD:293514	47/184 (26%)
		ATG_C	3507..3582	CDD:286423	23/74 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1642
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030