DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps13B and Vps13D

DIOPT Version :9

Sequence 1:	NP_651753.2	Gene:	Vps13B / 43550	FlyBaseID:	FBgn0039727	Length:	3731	Species:	Drosophila melanogaster
Sequence 2:	NP_729825.2	Gene:	Vps13D / 39448	FlyBaseID:	FBgn0052113	Length:	3919	Species:	Drosophila melanogaster

Alignment Length:	4451	Identity:	829/4451 - (18%)
Similarity:	1497/4451 - (33%)	Gaps:	1423/4451 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LESYITPILLSYVAKYVKNFRDEDAQVSLWEGEVTFQNLDLRLEVLEEELNLPVELVSGHIHELS 68
            |...||.:|.:|:.||::|.......|:|..|||..:|:.:|.:.| ...|||||:.:|.|.::.
  Fly     2 LRDLITWVLNTYLGKYLENLNSAQLSVALLSGEVELENIPIRKDAL-RSFNLPVEVTAGSIRKIK 65

  Fly    69 ILVPWTKLMSEPVKIVINTIEFV-------------AKLPDSESK-----QRRASFQREQRRKSK 115
            :.:|..:..:.|..|.|..:..:             .||.|.|.|     ...|.::.|:.::.:
  Fly    66 LQIPVRQFRTSPWCISIEGLFCIICPKNLDNWDYEKEKLQDLEYKLAVLDTAEAGWRSEKGKQME 130

  Fly   116 RESVEQPDQTKSPGPASSSSVVNKIINNINLQCHNIILKYVEDDIV--------VSMNVQTLNFS 172
            .......:.....|    :::...||:||.|:..::..::  :|||        ..:.:.:|...
  Fly   131 SYYFSSYNNWLKYG----TNMATNIIDNIELKISDVHFRF--EDIVDTGKSKICTGIKIGSLTAQ 189

  Fly   173 SAGEDWKPTMVDIHPVSVVMRKLLQVSDLTICLDKRNTAGRIEVCQ----EPVLYRCTLECRVLR 233
            |...||......::. :.:..||:::.:|::..|..:...:   ||    :.:|.:....|. ||
  Fly   190 SCDCDWTNGSYKMNN-NEMNYKLVELKELSVYWDLLHEDIK---CQSYSNQEILEKMHSTCE-LR 249

  Fly   234 KYN-----------------ANTVSTTSTTRIG--VFTKSLDINVSSLQFPMVMRLVKMLLELKP 279
            .:|                 ...:.|....|:.  :....:.|::|.:|   .::::..|.|::.
  Fly   250 SHNFIIKPICATARWKRDKCQQVIRTKDKPRVSCELLVPEVVIDISKVQ---RLQMLDKLSEIRQ 311

  Fly   280 AE-------------FEDDPQNPEDQEAVAEGSESQQGTESAGRSVFWWAWSLLPSFDTEAPSSS 331
            .:             .|.:|                         :.||.::.:
  Fly   312 VKEVRQYRLKRPTCTVESNP-------------------------IAWWKYATI----------- 340

  Fly   332 CDTPTGHAFDLGVYAEELNFQLKNSEYFTDQSMGGIKRIRYTPILRISLGGLYYERTILKECDWA 396
            |     |.||.          .||.|.:....    :.:||.         |.|:..||
  Fly   341 C-----HGFDF----------KKNEEKWLMLK----ENLRYM---------LLYKSIIL------ 371

  Fly   397 NVKAGLSSMCMEPLGAYRSD----DL-VDRNLVNTQEFQQERSFIDKSLFDENYMFA-ERSWCSY 455
            |....||:...|......||    || :.|.:...:.|.:..:|..::...:|.:|. ..:|..:
  Fly   372 NPNENLSAADKEFKAYIESDRKISDLTIMRRICFEKVFTKGFAFESQNEQGKNMLFHWFPNWMGW 436

  Fly   456 ---------NYADYVARNTDEYMLFRSPVLAFDVIEHRVPKPSSHPVAESQLRDLGVRIQYRLLS 511
                     |..|...::.::.:|.        .:|:.:...|.                  |.|
  Fly   437 YANSPSTPNNEQDESLKHLEDDILV--------ALENSLQNSSD------------------LKS 475

  Fly   512 AGITFHFSQSFVQVKKVISDLIRPYDYPGYRSESMKDEDRGVPEPENKNSEMTIPDLEYLMGLVP 576
            ..:..|||      .|::..|:           .::.||: :.:..||:.||...:....:.|.|
  Fly   476 DAVFGHFS------IKLLKGLV-----------ILQTEDK-LNDGRNKSMEMQFNNFSAYLQLSP 522

  Fly   577 -TCNYKIELRNIVVQLYPRQQQDESSAINQHQLTTTVRQSLLPYLQLKISLVEGTMCGPVNPVRL 640
             ..:|.:.:....|.|.     |::|:...|..                 |::........|.:|
  Fly   523 QLTSYTVGISLQEVYLI-----DKTSSDTMHNY-----------------LIKPQTGNTATPNQL 565

  Fly   641 VQ-------LITHLEEKPRDVVNACYNC----FHFNVKNLAL-MIMNT----------------- 676
            |:       ::..|:.:         ||    |..|:|:..| :|.|.
  Fly   566 VKNAALQEDILFQLQYE---------NCNHLRFQLNIKSKGLDLIYNEDAIQWLLDFLADSNSFK 621

  Fly   677 -TPDNGRAKLLNIPRVQVNWNRLLAPH-----LWR---QNEAP----LETSEIKSEI-ITLEFSK 727
             :|.|..||..:..:   |||.:.:.:     :|.   :..||    ||..::.:.: :.|:|.|
  Fly   622 YSPRNRVAKKTDFMK---NWNEMFSGNEVNRKIWMFEIEIFAPRIIFLENYKVSNSLMVLLDFGK 683

  Fly   728 REL--IIAKRLVPLISSFSGQDLCD---------------------LAHIVANVNVNSDVIKLQS 769
            .|:  :..||::|:|.|...::..|                     ...::.|....|.:.|
  Fly   684 LEMRKMEVKRVIPVIESAVTENTSDDDETYLTPCSTPPASEKSGSESPTLLENPKTESFLNK--- 745

  Fly   770 VGTKLNLVYHK--YHTHLAAVGSLQGVHTDAVHTKMNIR-NVVLSTSKNAD-------NKWLEMQ 824
             ..:|..|.|.  |..:|....:||     .:..|...| ...|.||.|..       |..||.:
  Fly   746 -NVQLEYVLHNKIYDKYLINFTNLQ-----VLVCKYEERWQACLKTSSNFHLIDKFNINLTLEQR 804

  Fly   825 CQFPLEE---------------VHSEQEKIPGTVVCLWLEP-----------FRITTDIYLLQFL 863
            ..|.::.               :|..:|.|..  .|..::|           :|....||..:.:
  Fly   805 NIFTVDPEYPSFMLFGTCPTILIHGNEELINN--CCNIMKPIIKASKEMENIYRGGNTIYASERI 867

  Fly   864 -NFSDNSGRQITKDKEVETDLESVNQSEPPITQSVSNYSTISASAIAFNDFQPRRISRNNSRKIS 927
             |.:::...::..:..::..:..:..:|    :|::....|.|.|....:.....||.:....:.
  Fly   868 KNLAEDDRSRVVIEFVMDQLVIEMQSTE----RSIAELQIIGARAGLTKEPHETNISMSVHGLLL 928

  Fly   928 V-------PEETVHLSSERDERHTQAEPLT--------IPVANKPQPSNFDTTDFVKRLTKMVVL 977
            |       |:..:.::|   .||...:.|:        :...:...|:.||.......:||.|..
  Fly   929 VDAIQSFGPDFELLVAS---HRHVGMDSLSGSLKHSAIVSPTSPGSPNFFDRATSPHMITKAVQN 990

  Fly   978 VEIAQAKIDVCEVMMRKTPGHTDVEYTSIRLPHMKVKSGNCEAIQRGNIRGVIPVASNTELLNWV 1042
            :::.....:.|:          |.:.|::....:|:               |.|..||:..|:
  Fly   991 IKMGDRSTEFCD----------DEDSTALISVDIKI---------------VPPNESNSMQLH-- 1028

  Fly  1043 FDLNEFNVCYRRANVTEMIIAPVRTTITLALSFKTSDKVDGSKGKEDKCANTCSINVHVDMSAIN 1107
                                       |.:::|.:.|.:          ||..:|     :..:|
  Fly  1029 ---------------------------TTSITFNSLDII----------ANQDTI-----IEILN 1051

  Fly  1108 IFAQRVKLLHEHCLIISKMYGSLCPDEPASKWQTGKMKPRLEVYTGSAQNYPVIKEFLELD---- 1168
             ||:|.       |:...::.|..|:.|  |..|......::.....:.| .:..:|..|:
  Fly  1052 -FAKRT-------LLAQNIFPSESPESP--KEATEAPVDVVDQVDHKSHN-EIFFDFFRLNILLL 1105

  Fly  1169 PNFEAPKVKSAPKSSVILFCQWTIPRISFEME---------------NSNDFKHSKIVMSLEDLL 1218
            ...:..|.....|...:...:..| ..||:.:               .|..|.|.:|:....|.:
  Fly  1106 YTIKRDKFNVGRKVGTVTLTEAKI-NASFQSDLSIIGSLGGIQVIDITSEAFCHPRILSVGRDQI 1169

  Fly  1219 LNIDKHSDFNK--ITTKIEN--FGLNYYEE-KHEEWEKID-----------DLHIKMLGDS-TNL 1266
            |   :.||.||  :.:::.|  :..||.|| |.:|.:.|.           ...::|...| |:.
  Fly  1170 L---RASDTNKQTVLSQLSNEIYSNNYNEETKSDESDAISFQSHWSDKTTCTFQMRMASASYTHC 1231

  Fly  1267 PL----ISVVITTV--SLEDLYAKIGARNPHNKQHTIS-EVLIEVQPIEMV-------LNLDQIT 1317
            |.    ::..||..  ||.:....||     ||...:: |.:.:|:.:|.:       ...|...
  Fly  1232 PRFLRDVNACITYFKRSLREFATSIG-----NKATDMAKEFVQQVRAVEQIGPVYPQRNRQDNWL 1291

  Fly  1318 EFMV--PICEVLEIIGNSASAQSAN--KPSAPVPSKITTVQDLPMVHLNSKGIYVY-LPLSTGKK 1377
            :.::  ||. :|.|...|.:...||  |.|.....|..:.:......:..|..||| |.:..|:.
  Fly  1292 DIIISSPII-ILPISNTSTNVLIANLGKISCSNAVKCDSDEFNESYTIEIKNTYVYSLNIDEGEY 1355

  Fly  1378 SCSVLLLRIESIQLTPSL-ENPLVRQLVR--PDIYQKAAELNMLSTPGALVE-------DRQYEL 1432
            |.:|  ...::....|.| :..:..||..  .|...:..:||..|..|::||       .:||||
  Fly  1356 SFNV--HPAKNKDAIPILHDTAITLQLYAGYSDDNDEDKQLNRFSIKGSMVEALKVSLNRKQYEL 1418

  Fly  1433 SVRRVSLSTGNWKQTQEYRIEKTLASKHDNPAFEWNNQ--SQSTELDHMEIFKDFDFIMIYAPAI 1495
            .:..:..:|                        .::|:  ::|.|||     ::.|.    .|..
  Fly  1419 LLESIRYAT------------------------NFSNEVLNESDELD-----QNGDI----EPTA 1450

  Fly  1496 SYDRFLVCGQSVEYNCATDFVASLNTHQISLISCII----VRAQRLGCIID-QVCVKNAELPKAR 1555
            :.|...:...:::::.....:...|.:...||:...    |:....|...| :|.:|:..:...:
  Fly  1451 NIDAESIISTTIQFSVPVFQINLQNEYHNDLINLTFKNFNVKHISKGFDKDVEVVLKSVLMEDLK 1515

  Fly  1556 SHKTLGNISKYNSVDNSIYFPADPKVFKKDTWIPKSSKKLVSERLSYTNASTSFTDAKGSSDYFY 1620
            |..|....:...|||      .:.|: ||:.....|...|.|...|..|.|:|....      ||
  Fly  1516 SDLTSPFRNMVTSVD------LEQKI-KKNEMTSSSCPDLPSYCNSLKNRSSSVPSC------FY 1567

  Fly  1621 GSCQ-----------SDSGIHLGTRMKGYSRSLAAEEINRSGRQPFVLSYPSSVSFVA---GIFV 1671
            ...|           |.:...||.:.:..:..:......||. |...|...||:.|..   .|.|
  Fly  1568 NHMQVKVFGGDQKYTSSNKNELGKKKESQTLVIYKSHTGRSA-QNGKLEQTSSIQFNCLNLAICV 1631

  Fly  1672 LKIYDVL-----------------ELEELERPVMKPLFLMTVSQPSFMSTQNFKAAVTQASIFNV 1719
            .:.|.:.                 |::.:|:.:.|....:.||..||    ||.....::.:..|
  Fly  1632 ERWYTIFDFFGLVSVDNVNEKYPEEMKLVEKHIDKVCSKLKVSIRSF----NFTLIRNESLLSRV 1692

  Fly  1720 NISVAKADVDGKVDSERFNESVFATL--------PGQLGSSGIPPPLLTIKTQYDRLH------- 1769
            |:|                .:||..|        .|.|||..:     ...|:|..::
  Fly  1693 NVS----------------NAVFMILQDPYSKIVEGCLGSVSV-----NDLTKYGNIYKQKFLTS 1736

  Fly  1770 ----------QKEVDVE----LRKPILLRICENTIKQLASDVFRIYTVLH---------ETPCFN 1811
                      :|.||:|    |.....|||..:.:..:.:.  |..|.||         :||.
  Fly  1737 GTEALNFVYKKKLVDLEALNTLDTDSTLRINMSAVHYIHTK--RFSTELHVFVKDLLQLQTPV-- 1797

  Fly  1812 VRSPRPVPEGSQLRQLKMNCYNADRFHLSCDRITAKFYDEERSYKCS----FVWLDVSTRIKFSS 1872
                        :|:||.                   :..|::.:.|    .:..|....:..||
  Fly  1798 ------------IRKLKK-------------------HGSEQNMRPSKMKLVIQADSPVIVLPSS 1831

  Fly  1873 RPQKAVIRSNIGSFYVQSGEKMLLH-----PLLMRLSVDLVSEPWSEELLVNATLKLNYLHIDAG 1932
            ..:..||.:.:|.|.:::.    .|     .::.::|    :.|..:|:|....:.|..:::.:|
  Fly  1832 YNRNEVIIAYLGQFSLKNS----FHFASDNNIISKMS----ATPSKDEILDVMRIDLVNINLFSG 1888

  Fly  1933 VFSILQLQKAQQGVNRIREYADREWQQFLRSRPVLGTPKDVSPCNLIKCTPSHESIERIKRPLKS 1997
            ..|.:: .||.|..:|| ..||   ..|||    ||.|.....|.|      |..:|   |.|.:
  Fly  1889 ERSSMK-AKADQEKDRI-IIAD---MNFLR----LGQPFFNESCFL------HLQLE---RNLSA 1935

  Fly  1998 NAEFYQDDLRA-GAFQFV--------------YLNSESVLPMPYQVQIIKKNY-GIICWRYPQPR 2046
            :|.....|:.. |.|..:              :||:.    :..|...|..|| ...|   ....
  Fly  1936 DAHRVCPDISVQGTFSKLSGIINIQQYKLIRSFLNNN----IGEQTDDIYMNYHNNSC---TSIE 1993

  Fly  2047 QMTSIHIYP---VPMPVSRPIHIRCRMEYFSETHETFLHYCDFMLSETSTKQLTPPDRPICATIW 2108
            ::::|::.|   |...||..|.||..:|..|            :|...:|.|....:...|
  Fly  1994 RLSTINLMPKNEVSKIVSILISIRILLEDVS------------LLLALNTSQSAAIEPLAC---- 2042

  Fly  2109 RVVILQSLISVDGTCFEGSEDEDLSIEYLQSDFK-VDENNDF----------ILHP--------- 2153
             :..|:|.:.:| ...:||:|.||    :.|:.. |||.|:.          ||.|
  Fly  2043 -IHFLKSTLEID-LFSDGSQDIDL----ISSNILIVDERNESDKSNENVFKNILEPSKKEVRIEN 2101

  Fly  2154 --KVLVGCMR---------------------------------------------------IDTV 2165
              :|.|.|.:                                                   |||.
  Fly  2102 SVQVEVHCRKKATFSKYTIMLNNMRVFALLSFLDQLKSYLQEDSPAPVVNNAANQIAQKPQIDTS 2166

  Fly  2166 FRAEKVPKLQLLLCCQDIELNFV---NQTDNTGELPKQLNKYRLRQTPNITQTFLTV-HVE---- 2222
            ...|.|..:      .|.|:.|.   ::.|:...:.|.......:...||....|.: |:|
  Fly  2167 ISTEYVVNI------TDSEIIFAEECSRLDSNAIILKSTTVICYKPNSNIVPLSLDINHLEIFSC 2225

  Fly  2223 --DLQMHSRIYSRNDFSLQTEMRARVKCLD---YGFLNM-LDVLEPMKFSSYVRL----TDYPRS 2277
              |.:..|.:...:.|:|..|:|:  .||:   ...||: |..::...||...||    |..|::
  Fly  2226 TLDAEEESALSIIDPFTLIIELRS--NCLNILIQKHLNIRLSYVDVKLFSRMARLLPTQTSRPKN 2288

  Fly  2278 LV-QANFLVDKLR--LNCGPHVIHTLLSSKYH---------WQEVLQQKDVRH-VLMPKLVIVNR 2329
            :: :|:..::|..  :..|..:...|.:.:.:         |....:|...|: .|..|..:|:.
  Fly  2289 VISKADSDLEKAAPLVAMGFEISDCLYAMQINNWRINDAAIWLSQQKQNTYRNPALEMKTAVVDA 2353

  Fly  2330 ------------------IQTPIS-FGQTNTVEKIPVNPGEVQLYHFRSCSHVQELTFFITNPKT 2375
                              ::..:| |....|.:....||.|..:.|:.           :.|
  Fly  2354 SLISVFIIDDCMDADVPLLEVSLSKFLLNFTFQTQDPNPKETNIRHYS-----------LGN--- 2404

  Fly  2376 LLVDSSDSVH-----------IALKFED-------EEKIHNLRVGEYCITLK-LAKLSTTQIYIL 2421
              :|:..||:           :|..:|.       :..:.|.:..|..|:.| :.||:.|..:
  Fly  2405 --IDTEVSVNYYNRRLSGWEPVAETWESNLNWKYTKGHLDNKKRFEIGISSKQMLKLNVTSTF-- 2465

  Fly  2422 VKGQIELVSMVPFNLVTEFREEEI-NYDESTP--PEHLLLSKERSSYYQNVKRNADINMRLKLTA 2483
                |||..||..|...:|.:... |:.:.:|  |..|          ||:.....:...:....
  Fly  2466 ----IELFHMVLKNWTNDFNDNGAKNFRQRSPFIPFAL----------QNLSGTPLLFKPIYAPL 2516

  Fly  2484 G-LGRGRTGDIPLKTNNNLPWLVKVPTQSA---------------------QQFISIWVRILRED 2526
            | |.|.....:.|..|    |....|.::.                     |.|:.|....|...
  Fly  2517 GDLTRSDLQQVELIKN----WYSVQPNETKTFDFSQKSKLRHVHSHQLNLHQIFVQIHGWTLIGP 2577

  Fly  2527 IKMDKPAEDFQPQKI----------------------LICIWPIFEICN------MLSCAVKATE 2563
            |.:||....|:..|:                      ||.:.....:.|      .|...:|.|.
  Fly  2578 ISVDKVGMFFRTTKLDSQFLTKSRIVFDISLIGSAQKLIKVKSSLGVINKLDRNVFLKMTLKGTH 2642

  Fly  2564 STTGESSTIEAMGGRWAL-------------NTATTHATEHNIGFTFSGIL-RGSSKDEYSLMLR 2614
            |....|.::.......::             ||:.:.|.| :.||:...|| :...||:...:|.
  Fly  2643 SDGLSSISVIKPNDELSVPLKFIDASLYVAHNTSESDAYE-DTGFSNEEILWKACGKDDTRQLLA 2706

  Fly  2615 TMDWHKFFYYDPTVWTIENALHKLGKSSKRKWP-----LNDPEELRVSRVLDFENAFDVKYQTKA 2674
            ..|.:|...|     |..|...::....::..|     |..|  |:::.:|..:..|  |....|
  Fly  2707 GYDTNKSILY-----TFVNISREIYHCKEQNLPGHKITLLPP--LKINNMLCCDLMF--KIHEHA 2762

  Fly  2675 TREF-----------SCCQGLDVTAWGMFINGTGLYVAIFMIQEQARLDLKANSLQMMPKLKSAF 2728
            |...           :.||.|:::          :.:..|.:..|.::.:....: :.||||
  Fly  2763 TGRINSSESVNIYNVNICQPLNLS----------ITLDNFQLSGQLKIPVSHRGV-IEPKLK--- 2813

  Fly  2729 TIDVRFDNGWKSSTPICLEDFTQKSSSNAGRSLYLRYNSFVDIVIVERDEVLRLILEYRQE---- 2789
            .||::     |....:.:   :.:|....|..||:.    ..:.|:.:   ..|.|.|:||
  Fly  2814 LIDIQ-----KRELHVRV---SIQSVPGKGMELYIS----APVWIINK---TGLPLIYKQEGTSH 2863

  Fly  2790 ---------DDGRRLFKLRSKFVFTNFTDVVLN-ALTLAMDHKENSTREEVEAYSICKK-ARSLV 2843
                     :..|::..|     ..:|:|...: ||.|.:.....|.....:::|..|. |...:
  Fly  2864 TAAGQFEEHETARQVAPL-----MFSFSDQEGSPALVLRLGKAYGSNNMWCKSFSTHKDLADRDL 2923

  Fly  2844 SSESTKNCSGNAMDV-----------FYDLNAHKAKHNCDTAFVYF--VCFSVGGSRE-----IS 2890
            .:|:||......:.|           |..|:.....||.....:.|  :|..|...|.     ||
  Fly  2924 RAENTKGSYAIGISVRRGRGLYACTTFVTLSPRFHLHNRSGYKLEFMQLCDIVNYDRPDPRKIIS 2988

  Fly  2891 IPIP-----------------LAVPFTRRCFSLQAGP----------------ESIPLMITLIEK 2922
            .|:.                 :.:|....|...:..|                |...|.:.:|.|
  Fly  2989 APVDCNFAFHWPNWDQEQIICVRIPEIECCCWSKGIPIKDVQSLYINVRNEWGEMFFLRLEIISK 3053

  Fly  2923 DNVHYLNVFRDT---APAIVISNNTNVKFIVAQ--------TSASENSNVSCTNSEFVGRNFEWN 2976
            | ..::.:|.|.   .|.|.|.|.:.|....:|        |.....|::|....:.:|:
  Fly  3054 D-ATFILLFTDARTLPPPIRIDNCSEVVINFSQLRSKPVWITPVRPQSSLSYVMDDPLGQ----- 3112

  Fly  2977 QLVL---PHSNCYYTPPQMYANFPDVEFTMCNLSLAVYKDKLCAKNKIAWSKPIRTDKSWQKFLH 3038
            |::|   |..|.             :||.:.|            ||.      |:...::..|::
  Fly  3113 QILLMEAPGGNM-------------IEFPINN------------KNN------IKKTLTYTNFIY 3146

  Fly  3039 VPHHGDV--------------------KVVVCDKHRAIRLNIYYIAQ--QLEFSVKDLRSRLTKP 3081
            :...|..                    |||:.:|:...|..::.:..  |||........:....
  Fly  3147 IAFQGTFERSNEEENTHRQLVLGVRGKKVVIVEKNSGDRSQLWLMNSNGQLEHEGSTPPIQTNDA 3211

  Fly  3082 ENVLMPSQEQAAPRPDESSE---QENDTKRVTL-------------PNMVTCAHFNE-------- 3122
            ..|.:....:.||.|.|.:.   :..:.:|||.             .||...:.|.|
  Fly  3212 NAVRLVLDLEKAPNPMEFTNLVVRTPNKQRVTTQTWRFENGRLMCHANMCVQSRFGESGLKPNYE 3276

  Fly  3123 ----ECESKTQTRIKIFIKSFVFS---------LQTDNRENDFVKT-EVCNIYADDSMLIYDDDD 3173
                ..|::..:..:|.|...:.:         |:...:.:..:.| |:|:|....:.:....|
  Fly  3277 AVVGRTENRASSSKQIPIGQHIVAQKLRPGSGQLELSTKMDGPISTIEICDIKIKQNSVFLTPD- 3340

  Fly  3174 DQRELRLQLPNLQVDN-QLYSSGKYDF--PVLLCAEK--------LYRRNCSLPQVYDLDHV--- 3224
                  |...:..::| |:...||..|  ..|:..|.        :.|:.|.......|||:
  Fly  3341 ------LLWMHASLNNRQITDKGKVSFVHEYLINVELVKGIGISIIARKPCEEIMFISLDHINCD 3399

  Fly  3225 YKQQAQRTPVSLFTFIFYQDEMQLQNVRCQIPPFRVYIEDAYLNQLLEA---------------- 3273
            ..|.|....:.| ...:.|.:.||.:.   :.|..::.:.:  |.|.|.
  Fly  3400 IVQSALENSLDL-NIAYIQIDNQLLDA---VSPIALHTQTS--NDLEETQNAVVLKLKMLPSPNK 3458

  Fly  3274 --------LVECEPSNCVYSPPVEQDQILLPAGMTLLPDQVVAQSL------------------- 3311
                    .::.:||....     :::::|.....|...::..|:|
  Fly  3459 NAIIFKYLTLDLKPSTASL-----EEKLILKVASFLGYGKINRQNLSVQYQFENTDDKPFLQDMK 3518

  Fly  3312 -YISEPLRLNSFTVEPLNLLLSVHTSSRLYIAL--------------DHSPLSFSRY-ERQQILT 3360
             |..|.|.:.:..|.     ||..|||:|.:.|              :.:.:...|| ::....|
  Fly  3519 RYYFENLSIGATQVR-----LSAFTSSKLPVELHETKKALGLTLIKFEDALIELDRYSDKLHFET 3578

  Fly  3361 VPLRFGQSLGLHYLSGAIFGAGWVVGSLEILGSPSGLARSFSTGLRDFVSMPVQGLFRGPWGFLV 3425
            :.: :.:.|..||::...:.|..::||::.||:|.|.|...|.|        |.||
  Fly  3579 MDV-YRKELKKHYINQVKWHAAAILGSVDFLGNPLGFANDLSEG--------VSGL--------- 3625

  Fly  3426 GVTQGSA-SLLRNVTAGTVNSVTKLAGSVARNLDRLTLDAEHIELTEARRRARPQGFADG-LTQG 3488
             :.:||. ||::|||.|..||..||..:::.:|.::.|| :|...|..|........:.| |..|
  Fly  3626 -IFEGSVKSLVKNVTHGISNSTAKLTETLSDSLGKVVLD-DHDNETRQRILELQSNTSGGHLAAG 3688

  Fly  3489 LTGLGISLLGAVGGLAHHTLEARSSVGV---IAGLTKGIVGALTKPISGAAEMLALTGQGVLHT- 3549
            |.|||..|||.|..:..||.:..:|.||   ::||.||:||.:||||.|..::.:.|...|..|
  Fly  3689 LKGLGFGLLGGVTSIVRHTYDGATSDGVPGFLSGLGKGLVGTVTKPIIGVLDLASETASAVRETS 3753

  Fly  3550 --VGFNAMPQQVEPSFIRN-----VALHG---SSNRIWSYLPEELSRDQMLFFSEIMLQISTQLR 3604
              ...||..::..|..:..     :.|:.   |..:.:.||..:.:..:.:...|..|....:.|
  Fly  3754 RDSHRNAPERKRLPRCVTGAPGGLLPLYSNRQSKGQQYLYLINQKNFSEKIISYEPNLWSDKEAR 3818

  Fly  3605 PALLFLTSSVLAIMQSDSE-DLAFASPISKV 3634
            ..||..|..|.....||:. .:.|...:|::
  Fly  3819 LRLLVSTEYVRIFSLSDANPTIMFECHVSEI 3849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps13B	NP_651753.2	Chorein_N	5..117	CDD:289396	33/129 (26%)
		VPS13_C	3319..3468	CDD:293514	43/164 (26%)
		ATG_C	3473..3546	CDD:286423	29/76 (38%)
Vps13D	NP_729825.2	Chorein_N	4..112	CDD:315323	31/108 (29%)
		VPS13	147..368	CDD:318996	45/294 (15%)
		VPS13_mid_rpt	<656..837	CDD:318998	37/191 (19%)
		VPS13	<2039..>2694	CDD:330393	127/709 (18%)
		SHR-BD	2836..3113	CDD:310922	54/294 (18%)
		VPS13	<3346..3802	CDD:330393	113/491 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453479
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR16166
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1642
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.060