Protein Alignment eIF2Balpha and EIF2B4

DIOPT Version :9

• Sequence 1: NP_651752.1
• Gene: eIF2Balpha / 43549
• FlyBaseID: FBgn0039726
• Length: 306
• Species: Drosophila melanogaster
• Sequence 2: NP_001305894.1
• Gene: EIF2B4 / 8890
• HGNCID: 3260
• Length: 544
• Species: Homo sapiens
• Alignment Length: 298
• Identity: 75/298 - (25%)
• Similarity: 138/298 - (46%)
• Gaps: 55/298 - (18%)

  Fly    14 VKYFLQLLDEDKDLSSGIAAIRTLLMILEKKQFGTIHILHTTMREAVAAMRNTDLSIAAIVSAGE 78
            :|.::..|.:.:.||   |::...:..|.|:    |..:.::.||..|   .::|. |||
Human   277 LKPYMSFLTQCRPLS---ASMHNAIKFLNKE----ITSVGSSKREEEA---KSELR-AAI----- 325

  Fly    79 LFCRFITLSLDDKHMEECRQIMLNRGKIFLTKLLNSRQVIAQQAQRFITDGCRILTHSRSRVVLK 143
                       |::::|              |::.:.|.|::.|.:.|::|..||.:..|.:|.:
Human   326 -----------DRYVQE--------------KIVLAAQAISRFAYQKISNGDVILVYGCSSLVSR 365

  Fly   144 ALITASQNKKSFHVYVTQGGTGNSGEEMVKDLHAAGIDCTLILDSATGYVMESVDFVLVGAEAVV 208
            .|..|....:.|.|.|........|...::.|..||:..:.:|..|..||:..|..||:||.|::
Human   366 ILQEAWTEGRRFRVVVVDSRPWLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALL 430

  Fly   209 ESGGIINRIGTYTMGLCAREMKKPFYVLAESFKF-----SRLYPLNQRDLPNEYKYSR-KHL--- 264
            .:|.:::|:||..:.|.||....|..|..|::||     :..:..|:.|.|::.:..| :|:
Human   431 ANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALA 495

  Fly   265 ---NDVS--KVHPLVDYTPPVYITLLFTDLGRLTPSAV 297
               |..|  .::.:.|.|||..:.|:.|:||.:..|:|
Human   496 NWQNHASLRLLNLVYDVTPPELVDLVITELGMIPCSSV 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Balpha	NP_651752.1	IF-2B	30..294	CDD:279362	69/277 (25%)
		GCD2	31..305	CDD:224105	71/281 (25%)
EIF2B4	NP_001305894.1	GCD2	240..538	CDD:224105	75/298 (25%)
		IF-2B	240..530	CDD:279362	73/293 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810