Protein Alignment eIF2Balpha and GCN3

DIOPT Version :9

• Sequence 1: NP_651752.1
• Gene: eIF2Balpha / 43549
• FlyBaseID: FBgn0039726
• Length: 306
• Species: Drosophila melanogaster
• Sequence 2: NP_012951.1
• Gene: GCN3 / 853896
• SGDID: S000001734
• Length: 305
• Species: Saccharomyces cerevisiae
• Alignment Length: 309
• Identity: 116/309 - (37%)
• Similarity: 176/309 - (56%)
• Gaps: 21/309 - (6%)

  Fly    10 DFDVVKYFLQLLDEDKDLSSGIAAIRTLLMILEKKQFGT----IHILHTTMREAVAAMRNTDLSI 70
            :|::.:.:|:.|:||.:::..||||..|:.:|..|...|    |:.:.::..|.:.::.|:
Yeast     3 EFNITETYLRFLEEDTEMTMPIAAIEALVTLLRIKTPETAAEMINTIKSSTEELIKSIPNS---- 63

  Fly    71 AAIVSAGELFCRFITLSLDDKHM----EECRQIMLNRGKIFLTKLLNSRQVIAQQAQRFITDGCR 131
            .::.:..::|.||:..:|   |:    |.|:|.::..|::|:::...||..||:....||.|...
Yeast    64 VSLRAGCDIFMRFVLRNL---HLYGDWENCKQHLIENGQLFVSRAKKSRNKIAEIGVDFIADDDI 125

  Fly   132 ILTHSRSRVVLKALITASQNKKSFHVYVTQGGTGNSGEEMVKDLHAAGIDCTLILDSATGYVMES 196
            ||.|..||.|...|..|:.....|...||:......|.::...|...||..|||:|||.|.|::.
Yeast   126 ILVHGYSRAVFSLLNHAANKFIRFRCVVTESRPSKQGNQLYTLLEQKGIPVTLIVDSAVGAVIDK 190

  Fly   197 VDFVLVGAEAVVESGGIINRIGTYTMGLCAREMKKPFYVLAESFKFSRLYPLNQRDLPN-----E 256
            ||.|.||||.|.|||||||.:|||::|:.|...:|||||:.||.||.|::||:..|||.     :
Yeast   191 VDKVFVGAEGVAESGGIINLVGTYSVGVLAHNARKPFYVVTESHKFVRMFPLSSDDLPMAGPPLD 255

  Fly   257 YKYSRKHLNDVSKVHPLVDYTPPVYITLLFTDLGRLTPSAVSDELIKLY 305
            :......|.|..: .|.:|||...|||.|.||||.|||||||:||||::
Yeast   256 FTRRTDDLEDALR-GPTIDYTAQEYITALITDLGVLTPSAVSEELIKMW 303

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Balpha	NP_651752.1	IF-2B	30..294	CDD:279362	101/276 (37%)
		GCD2	31..305	CDD:224105	111/286 (39%)
GCN3	NP_012951.1	GCD2	1..304	CDD:224105	116/309 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346668
Domainoid	1	1.000	161	1.000	Domainoid score	I855
eggNOG	1	0.900	-	-		E1_COG1184
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1080
Inparanoid	1	1.050	189	1.000	Inparanoid score	I920
Isobase	1	0.950	-	0	Normalized mean entropy	S860
OMA	1	1.010	-	-		QHG54281
OrthoFinder	1	1.000	-	-		FOG0002898
OrthoInspector	1	1.000	-	-		oto99322
orthoMCL	1	0.900	-	-		OOG6_102141
Panther	1	1.100	-	-	LDO	PTHR45860
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R371
SonicParanoid	1	1.000	-	-		X1674
TreeFam	1	0.960	-	-
	16	15.740