DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2Balpha and Eif2b1

DIOPT Version :9

Sequence 1:	NP_651752.1	Gene:	eIF2Balpha / 43549	FlyBaseID:	FBgn0039726	Length:	306	Species:	Drosophila melanogaster
Sequence 2:	NP_663346.1	Gene:	Eif2b1 / 209354	MGIID:	2384802	Length:	305	Species:	Mus musculus

Alignment Length:	305	Identity:	148/305 - (48%)
Similarity:	202/305 - (66%)	Gaps:	8/305 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 QDFDVVKYFLQLLDEDKDLSSGIAAIRTLLMILEKKQFGTIHILHTTMREAVAAMRNTDLSIAAI 73
            :|.::::||...:..|..::|.:|||:|||..|::.:..|:..|...:..|:..:...|.|: |:
Mouse     2 EDGELIEYFKSQMKGDPKMASAVAAIQTLLEFLKRDKGETLQGLRANLTYAIKTLCGVDSSV-AV 65

  Fly    74 VSAGELFCRFITL-SLDDKHMEECRQIMLNRGKIFLTKLLNSRQVIAQQAQRFITDGCRILTHSR 137
            .|.||||.|||:| ||:.....:|::||:.||::||.::..||..||.....||.||.|||||:.
Mouse    66 SSGGELFLRFISLTSLEYSDYSKCKKIMIERGELFLRRISLSRNKIANLCHTFIKDGARILTHAY 130

  Fly   138 SRVVLKALITASQNKKSFHVYVTQGGTGNSGEEMVKDLHAAGIDCTLILDSATGYVMESVDFVLV 202
            |||||:.|..|...||.|.||:|:.....||::|.|.|....:..|::||:|.||:||..|.|:|
Mouse   131 SRVVLRVLEEAVAAKKRFSVYITESQPDLSGKKMAKALSHLNVPVTVVLDAAVGYIMEKADLVIV 195

  Fly   203 GAEAVVESGGIINRIGTYTMGLCAREMKKPFYVLAESFKFSRLYPLNQRDLPNEYKYSRKHL--- 264
            |||.|||:|||||:|||..|.:||:...|||||:||||||.||:||||.|:|:::||....|
Mouse   196 GAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQEDVPDKFKYKADTLKSV 260

  Fly   265 ---NDVSKVHPLVDYTPPVYITLLFTDLGRLTPSAVSDELIKLYM 306
               .|:.:.||.||||.|..|||||||||.||||||||||||||:
Mouse   261 QTGQDLKEEHPWVDYTSPSLITLLFTDLGVLTPSAVSDELIKLYL 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Balpha	NP_651752.1	IF-2B	30..294	CDD:279362	130/270 (48%)
eIF2Balpha	NP_651752.1	GCD2	31..305	CDD:224105	141/280 (50%)
Eif2b1	NP_663346.1	GCD2	5..305	CDD:224105	146/300 (49%)
Eif2b1	NP_663346.1	IF-2B	17..293	CDD:279362	132/276 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850477
Domainoid	1	1.000	244	1.000	Domainoid score	I2198
eggNOG	1	0.900	-	-		E1_COG1184
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1080
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2947
Isobase	1	0.950	-	0	Normalized mean entropy	S860
OMA	1	1.010	-	-		QHG54281
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002898
OrthoInspector	1	1.000	-	-		oto92838
orthoMCL	1	0.900	-	-		OOG6_102141
Panther	1	1.100	-	-	LDO	PTHR45860
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R371
SonicParanoid	1	1.000	-	-		X1674
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740