DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF2Balpha and EIF2B1

DIOPT Version :9

Sequence 1:	NP_651752.1	Gene:	eIF2Balpha / 43549	FlyBaseID:	FBgn0039726	Length:	306	Species:	Drosophila melanogaster
Sequence 2:	NP_001405.1	Gene:	EIF2B1 / 1967	HGNCID:	3257	Length:	305	Species:	Homo sapiens

Alignment Length:	304	Identity:	152/304 - (50%)
Similarity:	203/304 - (66%)	Gaps:	8/304 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DFDVVKYFLQLLDEDKDLSSGIAAIRTLLMILEKKQFGTIHILHTTMREAVAAMRNTDLSIAAIV 74
            |.::::||...:.||.|::|.:|||||||..|::.:..||..|...:..|:..:...|.|: |:.
Human     3 DKELIEYFKSQMKEDPDMASAVAAIRTLLEFLKRDKGETIQGLRANLTSAIETLCGVDSSV-AVS 66

  Fly    75 SAGELFCRFITL-SLDDKHMEECRQIMLNRGKIFLTKLLNSRQVIAQQAQRFITDGCRILTHSRS 138
            |.||||.|||:| ||:.....:|::||:.||::||.::..||..||.....||.||..||||:.|
Human    67 SGGELFLRFISLASLEYSDYSKCKKIMIERGELFLRRISLSRNKIADLCHTFIKDGATILTHAYS 131

  Fly   139 RVVLKALITASQNKKSFHVYVTQGGTGNSGEEMVKDLHAAGIDCTLILDSATGYVMESVDFVLVG 203
            ||||:.|..|...||.|.||||:.....||::|.|.|....:..|::||:|.||:||..|.|:||
Human   132 RVVLRVLEAAVAAKKRFSVYVTESQPDLSGKKMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVG 196

  Fly   204 AEAVVESGGIINRIGTYTMGLCAREMKKPFYVLAESFKFSRLYPLNQRDLPNEYKYSRKHL---- 264
            ||.|||:|||||:|||..|.:||:...|||||:||||||.||:||||:|:|:::||....|
Human   197 AEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQQDVPDKFKYKADTLKVAQ 261

  Fly   265 --NDVSKVHPLVDYTPPVYITLLFTDLGRLTPSAVSDELIKLYM 306
              .|:.:.||.||||.|..|||||||||.||||||||||||||:
Human   262 TGQDLKEEHPWVDYTAPSLITLLFTDLGVLTPSAVSDELIKLYL 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF2Balpha	NP_651752.1	IF-2B	30..294	CDD:279362	132/270 (49%)
eIF2Balpha	NP_651752.1	GCD2	31..305	CDD:224105	143/280 (51%)
EIF2B1	NP_001405.1	IF-2B	15..293	CDD:395798	136/278 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160106
Domainoid	1	1.000	244	1.000	Domainoid score	I2194
eggNOG	1	0.900	-	-		E1_COG1184
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1080
Inparanoid	1	1.050	280	1.000	Inparanoid score	I2903
Isobase	1	0.950	-	0	Normalized mean entropy	S860
OMA	1	1.010	-	-		QHG54281
OrthoDB	1	1.010	-	-		D572463at33208
OrthoFinder	1	1.000	-	-		FOG0002898
OrthoInspector	1	1.000	-	-		oto89269
orthoMCL	1	0.900	-	-		OOG6_102141
Panther	1	1.100	-	-	LDO	PTHR45860
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R371
SonicParanoid	1	1.000	-	-		X1674
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750