DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cog7 and COG7

DIOPT Version :9

Sequence 1:	NP_651750.1	Gene:	Cog7 / 43547	FlyBaseID:	FBgn0051040	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_705831.1	Gene:	COG7 / 91949	HGNCID:	18622	Length:	770	Species:	Homo sapiens

Alignment Length:	802	Identity:	225/802 - (28%)
Similarity:	368/802 - (45%)	Gaps:	98/802 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDVSALSETTFSPAEWINANYKKFVEE--NGRDDSEAASAFIRSYVAKLQLYIFNVNNAVEESSR 63
            ||.|......|...|||||.::...:|  :|:.|..||     :.|.||||:|..||:||||:|.
Human     1 MDFSKFLADDFDVKEWINAAFRAGSKEAASGKADGHAA-----TLVMKLQLFIQEVNHAVEETSH 60

  Fly    64 QVVASMPRIAKESAALQADVHRLQEKMSAMRLEVAAVQSETGECMATLERLNTKSQKLQVAKESL 128
            |.:.:||::.::..||:.:...|:|:|..::.::...:.:|.:.|..|..::....::|:|.|||
Human    61 QALQNMPKVLRDVEALKQEASFLKEQMILVKEDIKKFEQDTSQSMQVLVEIDQVKSRMQLAAESL 125

  Fly   129 QESDGWGNLLAELEDGFERNDLKGVCDKLIALQKSLHAQEQLPGHAERQTQVEDFKNRLEALASP 193
            ||:|.|..|.|::|:.|:..|:..:..||..:|.||......|.::|:...:|..||||||||||
Human   126 QEADKWSTLSADIEETFKTQDIAVISAKLTGMQNSLMMLVDTPDYSEKCVHLEALKNRLEALASP 190

  Fly   194 SVVQCFAEGNTEQAQHFVQIFTSIQRLPQLQQYYRAVQK----NFWQQQWKQTLELQGTESQPQQ 254
            .:|..|.....:|::.||::||.|.|:|||..||....|    ..||:..:..|.|
Human   191 QIVAAFTSQAVDQSKVFVKVFTEIDRMPQLLAYYYKCHKVQLLAAWQELCQSDLSL--------- 246

  Fly   255 QQFLTLYYDQLLEHCQRQVKWCSNLFGENSPQPFLVIAELLPALQPTRDAHILQLLKTSNERLEM 319
            .:.||..||.||.....|::|.:.:|.:......:::.:.|.||.|:..:.:...::.:....|:
Human   247 DRQLTGLYDALLGAWHTQIQWATQVFQKPHEVVMVLLIQTLGALMPSLPSCLSNGVERAGPEQEL 311

  Fly   320 LAL---------FAK-VNHSFVLHLNSLLEQSHITLSEELHRLLGEAIFEYFHKFIQQYPRLEET 374
            ..|         ||| :..:.:.||:   |.:.:.::|     |.:|:::.:..:..:|..:||:
Human   312 TRLLEFYDATAHFAKGLEMALLPHLH---EHNLVKVTE-----LVDAVYDPYKPYQLKYGDMEES 368

  Fly   375 QLSTQVDRLSSNQATPSDGVRHLEESTRKLYEWLKEACERCASITSDLALCKLITLLNGIFKRQL 439
            .|..|:..:........|.|:.|..|..||:.....|.:||...|:.|..|.|::.|..:|.:.:
Human   369 NLLIQMSAVPLEHGEVIDCVQELSHSVNKLFGLASAAVDRCVRFTNGLGTCGLLSALKSLFAKYV 433

  Fly   440 ESFGRIQRQIGLSLGSSSYAAQS---ENWSLLQYTMSQLQCLADFQVQLHQFEQDLHTRMVMLSN 501
            ..|....:.|............|   |:|:..|.::..:....:.......|||.|..|::..:.
Human   434 SDFTSTLQSIRKKCKLDHIPPNSLFQEDWTAFQNSIRIIATCGELLRHCGDFEQQLANRILSTAG 498

  Fly   502 R-LTKPSNRGPITIFQTCDHAARTQLLNSIA------DYQQKKSEATDSLGIFPQIYATLKSHFA 559
            : |:...:...:..||   .:..|...||..      :|.||.:.|  ......:|..|||...:
Human   499 KYLSDSCSPRSLAGFQ---ESILTDKKNSAKNPWQEYNYLQKDNPA--EYASLMEILYTLKEKGS 558

  Fly   560 DTHDITLNILLQPIETHLAHIRPPVQDHA------------------------ASGI------EM 594
            ..|    |:|..|   ..|..|...|.|.                        .:||      |:
Human   559 SNH----NLLAAP---RAALTRLNQQAHQLAFDSVFLRIKQQLLLISKMDSWNTAGIGETLTDEL 616

  Fly   595 PSFSFAPQESITQIGQYLLTLPQHLEPLLLSPSSLLKQALEVCNIKYT----QAIP----CADVL 651
            |:||..|.|.|:.||||:::||.:|||.:....|.|:.||....:.:.    ..:|    .||..
Human   617 PAFSLTPLEYISNIGQYIMSLPLNLEPFVTQEDSALELALHAGKLPFPPEQGDELPELDNMADNW 681

  Fly   652 LSLVVEQCCVLYVTQILQIKSLPSSAATQLSVDIEYLSNVLEELGLSINLQLSQILTLLKAAPDQ 716
            |..:.......|...||||..|...:|.||:.||:||.||::.|||..:..|..|:||||..|:.
Human   682 LGSIARATMQTYCDAILQIPELSPHSAKQLATDIDYLINVMDALGLQPSRTLQHIVTLLKTRPED 746

  Fly   717 YLTLSSGCEPRLVTAIRQMRNI 738
            |..:|.|...||.|.:..||::
Human   747 YRQVSKGLPRRLATTVATMRSV 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cog7	NP_651750.1	COG7	2..737	CDD:287200	223/798 (28%)
COG7	NP_705831.1	COG7	2..767	CDD:287200	223/798 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155033
Domainoid	1	1.000	279	1.000	Domainoid score	I1710
eggNOG	1	0.900	-	-		E1_KOG4182
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H33431
Inparanoid	1	1.050	282	1.000	Inparanoid score	I2888
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55378
OrthoDB	1	1.010	-	-		D198192at33208
OrthoFinder	1	1.000	-	-		FOG0007167
OrthoInspector	1	1.000	-	-		oto90448
orthoMCL	1	0.900	-	-		OOG6_104376
Panther	1	1.100	-	-	LDO	PTHR21443
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4519
SonicParanoid	1	1.000	-	-		X5277
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800