DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cog7 and cog7

DIOPT Version :9

Sequence 1:	NP_651750.1	Gene:	Cog7 / 43547	FlyBaseID:	FBgn0051040	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_001070861.1	Gene:	cog7 / 768247	ZFINID:	ZDB-GENE-061013-463	Length:	767	Species:	Danio rerio

Alignment Length:	786	Identity:	214/786 - (27%)
Similarity:	365/786 - (46%)	Gaps:	69/786 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDVSALSETTFSPAEWINANYKKFVEENGRDDSEAASAFIRSYVAKLQLYIFNVNNAVEESSRQV 65
            ||.|......|...:|:|..:|  |.:  :|....|.|...:.|.||||:|..|||::||||.|.
Zfish     1 MDFSKFLADDFDVKDWVNGAFK--VAQ--KDAPGKADAHASTLVMKLQLFIQEVNNSIEESSNQA 61

  Fly    66 VASMPRIAKESAALQADVHRLQEKMSAMRLEVAAVQSETGECMATLERLNTKSQKLQVAKESLQE 130
            :.:|||:.::..||:.:...|:::|..::.::...:.:|.:.|..|..::....::|:|.|:|||
Zfish    62 LQNMPRVLRDIEALKQEASFLKDQMILVKEDIKKFEQDTVQSMQVLVEIDQVKSRMQLAAEALQE 126

  Fly   131 SDGWGNLLAELEDGFERNDLKGVCDKLIALQKSLHAQEQLPGHAERQTQVEDFKNRLEALASPSV 195
            :|.|..|.|::|:.|:..|:..:..||.|:|.||......|.::|:..|:|..|||||||.|..:
Zfish   127 ADKWSTLSADIEETFKTQDVAVISSKLTAMQGSLAMLVDTPDYSEKCVQLEALKNRLEALTSTQI 191

  Fly   196 VQCFAEGNTEQAQHFVQIFTSIQRLPQLQQYYRAVQKNFWQQQWKQTLELQGTESQPQQQQFLTL 260
            |..|....|:||:.||::||.:.|:|||..||....|......|:...:    ...|.:|| |:.
Zfish   192 VSTFNSLATDQAKLFVRVFTEMDRMPQLLAYYYKCHKAQLLTVWESICQ----SDAPLKQQ-LSE 251

  Fly   261 YYDQLLEHCQRQVKWCSNLFGENSPQPFLVIAELLPALQPTRDAHILQLLK--TSNERLEMLALF 323
            :||.||.....|::|.|.:|........:::.:.|.|:.|:....|.:.||  :.:.||::|...
Zfish   252 FYDTLLSTWHTQLQWSSQVFRNPCEVLTVLMIQTLGAMVPSIPDCIAETLKRCSGDCRLDVLLEL 316

  Fly   324 AKVNHSFVLHLNSLLEQSHITLSEELHRLLGE-----------AIFEYFHKFIQQYPRLEETQLS 377
            .:.:.:|...|.:.::..           |||           .::..:..:..||..||||.|.
Zfish   317 HQTSANFSRSLEAAMQPQ-----------LGECNLLKVAELVSCVYSPYKTYQIQYGGLEETNLL 370

  Fly   378 TQVDRLSSNQATPSDGVRHLEESTRKLYEWLKEACERCASITSDLALCKLITLLNGIFKRQLESF 442
            .|:..:...:....|.|..|..|.:|::.....|.:||...|..||:|.||..|..:|.:.:..|
Zfish   371 IQLSAVPLERGEVLDCVLELTHSVQKVFGLAAAAVDRCVKFTDGLAVCGLIKALRALFNKYVSDF 435

  Fly   443 G----RIQRQIGLSLGSSSYAAQSENWSLLQYTMSQLQCLADFQVQLHQFEQDLHTRMVMLSNR- 502
            .    .|:::..|. .:.:....:|:|:..|.::..:....:...|...|||.|..:::..:.|
Zfish   436 SVTLQSIRKKYKLE-DTPTSEVFTEDWTAFQNSVRVIATCGELLRQCGAFEQQLSNKILGRAGRF 499

  Fly   503 ---------LT--------KPSNRGPITIFQTCDHAARTQLLNSIADYQQKKSEATDSLGIFPQI 550
                     ||        :.|.:.|...:.....:...:..|.:......|.:.|.:..:..:.
Zfish   500 LWEGFNPRSLTGLQEGVAERRSQKNPWQEYNYLQQSNTAEYNNLLETLHSLKEKGTGNSSLLAET 564

  Fly   551 YATLKSHFADTHDITLNILLQPIETHLAHI-RPPVQDHAASG----IEMPSFSFAPQESITQIGQ 610
            .|.|.......:.:..:.:...|:..|..: :|..:..|:.|    .::|:||.:|||.||.|||
Zfish   565 RAALTRLNQQANQLAFDSVFLQIKQQLFLLNKPEARGSASLGETLTDDLPAFSLSPQEYITNIGQ 629

  Fly   611 YLLTLPQHLEPLLLSPSSLLKQALEVCNIKYT----QAIP----CADVLLSLVVEQCCVLYVTQI 667
            |:::||.||||.:......|:.||....:.|.    ..:|    .||..|..:.......|...|
Zfish   630 YIMSLPLHLEPFVTQEDPALELALHTGKLPYPPEQGDDVPELENTADYWLGSIARATMQTYCDVI 694

  Fly   668 LQIKSLPSSAATQLSVDIEYLSNVLEELGLSINLQLSQILTLLKAAPDQYLTLSSGCEPRLVTAI 732
            ||:..|.:....||:.||:|||||::.|||..:..|..|:|||:..||:|...:.....||...|
Zfish   695 LQLPELSAHHTKQLATDIDYLSNVMDALGLQTSRTLQNIVTLLRVKPDEYRQTAKTLPRRLSATI 759

  Fly   733 RQMRNI 738
            ..:|.:
Zfish   760 ANIRGL 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cog7	NP_651750.1	COG7	2..737	CDD:287200	212/782 (27%)
cog7	NP_001070861.1	COG7	2..764	CDD:287200	212/782 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590069
Domainoid	1	1.000	274	1.000	Domainoid score	I1747
eggNOG	1	0.900	-	-		E1_KOG4182
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H33431
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2936
OMA	1	1.010	-	-		QHG55378
OrthoDB	1	1.010	-	-		D198192at33208
OrthoFinder	1	1.000	-	-		FOG0007167
OrthoInspector	1	1.000	-	-		oto38883
orthoMCL	1	0.900	-	-		OOG6_104376
Panther	1	1.100	-	-	LDO	PTHR21443
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4519
SonicParanoid	1	1.000	-	-		X5277
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800