DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cog7 and Cog7

DIOPT Version :9

Sequence 1:	NP_651750.1	Gene:	Cog7 / 43547	FlyBaseID:	FBgn0051040	Length:	742	Species:	Drosophila melanogaster
Sequence 2:	NP_001029061.1	Gene:	Cog7 / 293456	RGDID:	1566058	Length:	770	Species:	Rattus norvegicus

Alignment Length:	818	Identity:	228/818 - (27%)
Similarity:	368/818 - (44%)	Gaps:	130/818 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDVSALSETTFSPAEWINANYKKFVEEN--GRDDSEAASAFIRSYVAKLQLYIFNVNNAVEESSR 63
            ||.|......|...:||||.::...::.  |:.|..||     :.|.||||:|..||:||||:|.
  Rat     1 MDFSKFLADDFDVKDWINAAFRAGPKDGAAGKADGHAA-----TLVMKLQLFIQEVNHAVEETSL 60

  Fly    64 QVVASMPRIAKESAALQADVHRLQEKMSAMRLEVAAVQSETGECMATLERLNTKSQKLQVAKESL 128
            |.:.:||::.::..||:.:...|:|:|..::.::...:.:|.:.|..|..::....::|:|.|||
  Rat    61 QALQNMPKVLRDVEALKQEASFLKEQMILVKEDIKKFEQDTSQSMQVLVEIDQVKSRMQLAAESL 125

  Fly   129 QESDGWGNLLAELEDGFERNDLKGVCDKLIALQKSLHAQEQLPGHAERQTQVEDFKNRLEALASP 193
            ||:|.|..|.|::|:.|:..|:..:..||..:|.||......|.::|:...:|..||||||||||
  Rat   126 QEADKWSTLSADIEETFKTQDIAVISAKLTGMQSSLMMLVDTPDYSEKCVHLEALKNRLEALASP 190

  Fly   194 SVVQCFAEGNTEQAQHFVQIFTSIQRLPQLQQYYRAVQK----NFWQQQWKQTLELQGTESQPQQ 254
            .:|..|...:.:|::.||::||.|.|:|||..||....|    ..||:..::.|        |..
  Rat   191 QIVAAFTSQSVDQSKVFVKVFTEIDRMPQLLAYYYKCHKVQLLATWQELCQRDL--------PLD 247

  Fly   255 QQFLTLYYDQLLEHCQRQVKWCSNLFGENSPQPFLVIAEL----LPALQPTRDAHILQLLKTSNE 315
            :| ||..|..||.....|.:|.:.:|    ..|:.|:..|    |.||.|:....:.:.::.:..
  Rat   248 RQ-LTGLYHALLGAWHTQTQWATQVF----KNPYEVVTVLLIQTLGALVPSLPMCLSEAVERAGP 307

  Fly   316 RLEMLAL---------FAK-VNHSFVLHLNSLLEQSH--ITLSEELHRLLGEAIFEYFHKFIQQY 368
            .||:..|         ||| :..:.:.||     |.|  :.:.|     |.:|::..:..:..:|
  Rat   308 ELELTRLLEFYDTTAHFAKGLEMALLPHL-----QDHNLVKVVE-----LVDAVYGPYKPYQLKY 362

  Fly   369 PRLEETQLSTQVDRLSSNQATPSDGVRHLEESTRKLYEWLKEACERCASITSDLALCKLITLLNG 433
            ..|||:.|..|:..:........|.|:.|.:|..||:.....|.:|||..|:.|..|.|:|.|..
  Rat   363 GDLEESNLLIQISAVPLEHGEVIDCVQELSQSVHKLFGLASAAVDRCAKFTNGLGTCGLLTALKS 427

  Fly   434 IFKRQLESFGRIQRQIGLSLGSSSYAAQS---ENWSLLQYTMSQLQCLADFQVQLHQFEQDLHTR 495
            :|.:.:..|....:.|............|   |:|:..|.::..:....:...|...|||.|..|
  Rat   428 LFTKYVSHFTNALQSIRKKCKLDDIPPNSLFQEDWTAFQNSVRIIATCGELLRQCGDFEQQLANR 492

  Fly   496 MVMLSNRLTKPSNRGPITIFQTCDHAARTQLLNSIADYQ-----QKKSEATDSLGIF-------P 548
            ::..:.:....|            ::.|     |:|.:|     .|||.|.:....:       |
  Rat   493 ILSTAGKYLSDS------------YSPR-----SLAGFQDSILTDKKSPAKNPWQEYNYLQKDNP 540

  Fly   549 QIYA-------TLKSHFADTHDITLNILLQPIETHLAHIRPPVQDHA------------------ 588
            ..||       |||...:..|:     ||....|.|..:.......|
  Rat   541 AEYANLMEILYTLKEKGSSNHN-----LLSVSRTALTRLNQQAHQLAFDSVFLRIKQQLLLVSRM 600

  Fly   589 ----ASGI------EMPSFSFAPQESITQIGQYLLTLPQHLEPLLLSPSSLLKQALEVCNIKYT- 642
                .:||      ::|:||..|.|.|:.||||:::||.:|||.:....|.|:.||....:.:.
  Rat   601 DSWNTAGIGETLTDDLPAFSLTPLEYISNIGQYIMSLPLNLEPFVTQEDSALELALHAGKLPFPP 665

  Fly   643 ---QAIP----CADVLLSLVVEQCCVLYVTQILQIKSLPSSAATQLSVDIEYLSNVLEELGLSIN 700
               :.:|    .||..|..:.......|...||||.::...:..||:.||:||.||::.|||..:
  Rat   666 EQGEELPELDNMADNWLGSIARATMQTYCDGILQIPAVTPHSTKQLATDIDYLINVMDALGLQPS 730

  Fly   701 LQLSQILTLLKAAPDQYLTLSSGCEPRLVTAIRQMRNI 738
            ..|..|.|||||.|::|..:|.|...||...:..||.:
  Rat   731 RTLQNIATLLKAKPEEYRQVSKGLPRRLAATVATMRGV 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cog7	NP_651750.1	COG7	2..737	CDD:287200	226/814 (28%)
Cog7	NP_001029061.1	COG7	2..767	CDD:287200	227/817 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348908
Domainoid	1	1.000	275	1.000	Domainoid score	I1688
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H33431
Inparanoid	1	1.050	279	1.000	Inparanoid score	I2840
OMA	1	1.010	-	-		QHG55378
OrthoDB	1	1.010	-	-		D198192at33208
OrthoFinder	1	1.000	-	-		FOG0007167
OrthoInspector	1	1.000	-	-		oto97558
orthoMCL	1	0.900	-	-		OOG6_104376
Panther	1	1.100	-	-	LDO	PTHR21443
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5277
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.910