DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jon99Cii and PROC

DIOPT Version :9

Sequence 1:	NP_524554.1	Gene:	Jon99Cii / 43544	FlyBaseID:	FBgn0003356	Length:	265	Species:	Drosophila melanogaster
Sequence 2:	XP_024308770.1	Gene:	PROC / 5624	HGNCID:	9451	Length:	576	Species:	Homo sapiens

Alignment Length:	245	Identity:	67/245 - (27%)
Similarity:	115/245 - (46%)	Gaps:	26/245 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 IQGRITNGYPAYEGKVPYIVGLLFSGNGNWWCGGSIIGNTWVLTAAHCTNGASGVTINYGA-SIR 95
            :..|:.:|.....|..|:.|.||.| .....||..:|..:||||||||.:.:..:.:..|. .:|
Human   323 VDPRLIDGKMTRRGDSPWQVVLLDS-KKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLR 386

  Fly    96 TQPQYTHWVGSGDIIQHHHYNSGNLHNDISLIRTPHVDFWSLVNKVELP------SYNDRYQDYA 154
            ...::...:...::..|.:|:.....|||:|:   |:...:.:::..:|      ...:|..:.|
Human   387 RWEKWELDLDIKEVFVHPNYSKSTTDNDIALL---HLAQPATLSQTIVPICLPDSGLAERELNQA 448

  Fly   155 GWWAVASGWGGTYDGSPLPD-------WLQSVDVQIISQSDCSRTWS--LHDNMICINTDGGK-S 209
            |...:.:|||  |..|...:       .|..:.:.::..::||...|  :.:||:|....|.: .
Human   449 GQETLVTGWG--YHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQD 511

  Fly   210 TCGGDSGGPLVT--HDGNRLVGVTSFGSAAGCQSGAPAVFSRVTGYLDWI 257
            .|.||||||:|.  |....|||:.|:|...|..... .|:::|:.|||||
Human   512 ACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNY-GVYTKVSRYLDWI 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jon99Cii	NP_524554.1	Tryp_SPc	36..260	CDD:238113	66/241 (27%)
PROC	XP_024308770.1	GLA	117..168	CDD:214503
		EGF_CA	182..213	CDD:238011
		FXa_inhibition	255..290	CDD:317114
		Tryp_SPc	328..563	CDD:238113	66/240 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910