DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trp and Trpc6

DIOPT Version :9

Sequence 1:	NP_476768.1	Gene:	trp / 43542	FlyBaseID:	FBgn0003861	Length:	1275	Species:	Drosophila melanogaster
Sequence 2:	NP_446011.1	Gene:	Trpc6 / 89823	RGDID:	619788	Length:	930	Species:	Rattus norvegicus

Alignment Length:	927	Identity:	303/927 - (32%)
Similarity:	453/927 - (48%)	Gaps:	211/927 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LSDVEKNFILSCERGDLPGVKKILEEYQGTDKFNINCTDPMNRSALISAIENENFDLMVILL--E 91
            ||..|:.|:.:.|.|::|.|:|:|||..   ..|:||.|.|.::||..|:.||:.::..:||  |
  Rat    94 LSIEEERFLDAAEYGNIPVVRKMLEECL---SLNVNCVDYMGQNALQLAVANEHLEITELLLKKE 155

  Fly    92 HNIEVGDALLHAISEEYVEAVEELLQWEETNH---------------KEGQPYSWEAVDRSKSTF 141
            :...||||||.|||:.||..||.:|     ||               .|.|...:.|.|...:.|
  Rat   156 NLSRVGDALLLAISKGYVRIVEAIL-----NHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRF 215

  Fly   142 TVDITPLILAAHRNNYEILKILLDRGATLPMPHDVKCGCDECVTSQMTDSLRHSQSRINAYRALS 206
            :.|:||:|||||...|||:..||.:||.:..|||..|.|.||...|..||..||:||||||:.|:
  Rat   216 SHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCTECSQKQKHDSFSHSRSRINAYKGLA 280

  Fly   207 ASSLIALSSRDPVLTAFQLSWELKRLQAMESEFRAEYTEMRQMVQDFGTSLLDHARTSMELEVML 271
            :.:.::|||.|||:||.:||.||..|..:|.||:.:|.::....:||...|||..|.:.|:|.:|
  Rat   281 SPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYRKLSMQCKDFVVGLLDLCRNTEEVEAIL 345

  Fly   272 NFNHEPSH--DIWCLGQRQTLERLKLAIRYKQKTFVAHPNVQQLLAAIWYDGLPGFRRKQASQQL 334
            |.:.|...  |:    .|..|.||||||:|:.|.||||||.||.|.:|||:.|.|.|::..:.:.
  Rat   346 NGDAETRQPGDL----ARPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKF 406

  Fly   335 MDVVKLGCSFPIYSLKYILAPDSEGAKFMRKPFVKFITHSCSYMFF--LMLLGAASLRVVQITFE 397
            :.|:.:....|..:|.|..||.|:..|.:|.||:||:.|:.|:..|  |:::.||.      .||
  Rat   407 LVVLAVAIGLPFLALIYWCAPCSKMGKILRGPFMKFVAHAASFTIFLGLLVMNAAD------RFE 465

  Fly   398 ---LL------------------AFPWMLTMLEDWRKHERGSLPGPIELAIITYIMALIFEELKS 441
               ||                  .|.||                   |:.||::::.:|:.|.|.
  Rat   466 GTKLLPNETSTDNARQLFRMKTSCFSWM-------------------EMLIISWVIGMIWAECKE 511

  Fly   442 LYSDGLFEYIMDLWNIVDYISNMFYVTWILCRATAWVIVHRDLWFRG-----ID----------- 490
            :::.|..||:.:|||::|:.....:....:.|..|:       |...     ||
  Rat   512 IWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAF-------WHASKAQSIIDANDTLKDLTKV 569

  Fly   491 ------PYF--PREHWHPFDPMLLSEGAFAAGMVFSYLKLVHIFSINPHLGPLQVSLGRMIIDII 547
                  .|:  .|..|.|.||.::|||.:|..:|.|:.::.:|...|...||||:||||.:.||.
  Rat   570 TLGDNVKYYNLARIKWDPTDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIF 634

  Fly   548 KFFFIYTLVLFAFGCGLNQLLWYYAELEKNKCYHLHPDVADFDDQEKACTIWRRFSNLFETSQSL 612
            ||..|:.:|..||..|:..|..||...::|:.                      |:.:.|:.::|
  Rat   635 KFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEA----------------------FTTVEESFKTL 677

  Fly   613 FWASFGLVDLVSFDLAGIKSFTRFWALLMFGSYSVINIIVLLNMLIAMMSNSYQIISERADTEWK 677
            |||.|||.::.|..:.....|......:::|.|:|..:||||||||||:::|:|.|.:.||.|||
  Rat   678 FWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWK 742

  Fly   678 FARSQLWMSYFEDGGTIPPPFNLCPNMKMLRKTL------------GRKRPSRTKSFMRK----- 725
            |||::||.||||:|.|:|.||||.|:.|.|...|            |.|:..:..:.|.|
  Rat   743 FARAKLWFSYFEEGRTLPVPFNLVPSPKSLLYLLLKFKKWMSELIQGHKKGFQEDAEMNKRNEEK 807

  Fly   726 --------------SMERAQTLHD------------------------KVMKLLVRRYITAEQRR 752
                          |::|.|..|:                        |:||.|::||:...|..
  Rat   808 KFGILGSHEDLSKFSLDRNQLAHNKQSSTRSSEDFHLNSFSNPPRQYQKIMKRLIKRYVLQAQID 872

  Fly   753 RDDYGITEDDIIEVRQDISSLRFELLEIFTNNNWDVPDIEKKSQGVARTTKGKVMERRILKDFQI 817
            ::...:.|.::.|::|||||||:||||..:.|..|:.::.:|                      :
  Rat   873 KESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIRK----------------------L 915

  Fly   818 GFVENLKQEMSESESGR 834
            |  |.|..|..:.||.|
  Rat   916 G--ERLSLESKQEESRR 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trp	NP_476768.1	trp	16..776	CDD:273311	289/867 (33%)
		ANK	64..>168	CDD:238125	46/120 (38%)
		ANK repeat	69..98	CDD:293786	10/30 (33%)
		ANK repeat	99..135	CDD:293786	16/50 (32%)
		ANK repeat	137..168	CDD:293786	14/30 (47%)
		TRP_2	178..236	CDD:285535	29/57 (51%)
		BASP1	938..1158	CDD:283191
Trpc6	NP_446011.1	trp	81..896	CDD:273311	289/867 (33%)
		ANK	104..238	CDD:238125	53/141 (38%)
		ANK repeat	131..158	CDD:293786	9/26 (35%)
		ANK repeat	160..184	CDD:293786	16/28 (57%)
		ANK repeat	211..246	CDD:293786	16/34 (47%)
		TRP_2	252..311	CDD:285535	29/58 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3609
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.770