Protein Alignment trp and Trpc1

DIOPT Version :10

• Sequence 1: NP_476768.1
• Gene: trp / 43542
• FlyBaseID: FBgn0003861
• Length: 1275
• Species: Drosophila melanogaster
• Sequence 2: XP_063122323.1
• Gene: Trpc1 / 89821
• RGDID: 619783
• Length: 828
• Species: Rattus norvegicus
• Alignment Length: 806
• Identity: 285/806 - (35%)
• Similarity: 437/806 - (54%)
• Gaps: 100/806 - (12%)

  Fly    25 EEYILSDVEKNFILSCERGDLPGVKKILEEYQGTDKFNINCTDPMNRSALISAIENENFDLMVIL 89
            ||..|:  ||.|:|:|::||...|||||||....| .||||.|.:.|:|:...||||:.|::.:|
  Rat    58 EENTLN--EKLFLLACDKGDYYMVKKILEENSSGD-LNINCVDVLGRNAVTITIENESLDILQLL 119

  Fly    90 LEHNIEVGDALLHAISEEYVEAVEELLQWEETNH---KEGQPYSWEAVDRSKS---TFTVDITPL 148
            |::..:..||||.||..|.|.||:.||     ||   :..:|...:.::|.::   :.|:|:.|:
  Rat   120 LDYGCQSADALLVAIDSEVVGAVDILL-----NHRPKRSSRPTIVKLMERIQNPEYSTTMDVAPV 179

  Fly   149 ILAAHRNNYEILKILLDRGATLPMPHDVKCGCDECVTSQMTDSLRHSQSRINAYRALSASSLIAL 213
            ||||||||||||.:||.:...||.||.|.|.|..|......||||||:.|::.||.|::.:||.|
  Rat   180 ILAAHRNNYEILTMLLKQDVALPKPHAVGCECTLCSAKNKKDSLRHSRFRLDIYRCLASPALIML 244

  Fly   214 SSRDPVLTAFQLSWELKRLQAMESEFRAEYTEMRQMVQDFGTSLLDHARTSMELEVMLNF--NHE 276
            :..||:|.||:||.:||.|..:|.|||.:|.|:.:..:.|...||..||.|.||||:||.  :.|
  Rat   245 TEEDPILRAFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQARNSRELEVILNHTSSDE 309

  Fly   277 PSHDIWCLGQRQTLERLKLAIRYKQKTFVAHPNVQQLLAAIWYDGLPGFRRKQASQQLMDVVKLG 341
            |......|.:|..|.||||||:|.||.||:..|.||.|..:|:..:.|:|||...:::|.|:.:|
  Rat   310 PLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTVWFGQMSGYRRKPTCKKIMTVLTVG 374

  Fly   342 CSFPIYSLKYILAPDSEGAKFMRKPFVKFITHSCSYMFFLMLLGAASLRVVQITFELLAFPWMLT 406
            ..:|:.||.|::||.|:..:.:..||:|||.|..||..||:||...||
  Rat   375 IFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASYFTFLLLLNLYSL----------------- 422

  Fly   407 MLEDWRKHERGSLPGPIELAIITYIMAL-------------------IFEELKSLYSDGLFEYIM 452
            :..:.:|:..|.....|:..:|.:|:||                   |:.::|.|:.:||.:::.
  Rat   423 VYNEDKKNTMGPALERIDYLLILWIIALGLLVYTMYLVKDLCSASGMIWSDIKRLWYEGLEDFLE 487

  Fly   453 DLWNIVDYISNMFYVTWILCRATAWVIVHRDLWFRGIDPYFPREHWHPFDPMLLSEGAFAAGMVF 517
            :..|.:.::.|..|:.....:    |:.|..     ...:..|:.|..|.|.|::||.||...|.
  Rat   488 ESRNQLSFVMNSLYLATFALK----VVAHNK-----FHDFADRKDWDAFHPTLVAEGLFAFANVL 543

  Fly   518 SYLKLVHIFSINPHLGPLQVSLGRMIIDIIKFFFIYTLVLFAFGCGLNQLLWY---YAELEKNKC 579
            |||:|..:::.:..|||||:|:|:|:.|..||..::.||||:|..||.||  |   |...|:..|
  Rat   544 SYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQL--YDKGYTSKEQKDC 606

  Fly   580 YHLHPDVADFDDQEKACTIWRRFSNLFETSQSLFWASFGLVDLVSFDLAGIKSFT------RFWA 638
                  |..|.:|:...|    |.:...|..:|||..|.|..:..|    :..|:      .|..
  Rat   607 ------VGIFCEQQSNDT----FHSFIGTCFALFWYIFSLAHVAIF----VTRFSYGEELQSFVG 657

  Fly   639 LLMFGSYSVINIIVLLNMLIAMMSNSYQIISERADTEWKFARSQLWMSYFEDGGTIPPPFNLCPN 703
            .::.|:|:|:.:|||..:|:||:..|:|:|:...|.||||||::||:|||:|..|:|||||:.|:
  Rat   658 AVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPS 722

  Fly   704 MKML-------------RKTLGRKRPSRTKSFMRKSMERAQTLHDKVMKLLVRRYITA-EQRRRD 754
            .|.:             ..:.|:.|...:....|...::....:.|||..||.||:|: .|:.:.
  Rat   723 PKTICYMISSLSKWVCSHTSKGKVRRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTSMRQKMQS 787

  Fly   755 DYGITEDDIIEVRQDISSLRFELLEI 780
            ....|.:::.|:|||:|..|.|:.::
  Rat   788 TDQATVENLNELRQDLSKFRNEIRDL 813

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trp	NP_476768.1	trp	16..776	CDD:273311	284/800 (36%)
		ANK repeat	69..98	CDD:293786	9/28 (32%)
		ANK repeat	99..135	CDD:293786	14/38 (37%)
		ANK repeat	137..168	CDD:293786	17/33 (52%)
		TRP_CaM_bind1	797..860	CDD:467881
		PRK12323	<891..1102	CDD:481241
		PspC_subgroup_2	<1015..1156	CDD:468202
Trpc1	XP_063122323.1	None