Protein Alignment trp and Trpc4

DIOPT Version :10

• Sequence 1: NP_476768.1
• Gene: trp / 43542
• FlyBaseID: FBgn0003861
• Length: 1275
• Species: Drosophila melanogaster
• Sequence 2: NP_536321.1
• Gene: Trpc4 / 84494
• RGDID: 621276
• Length: 977
• Species: Rattus norvegicus
• Alignment Length: 926
• Identity: 374/926 - (40%)
• Similarity: 555/926 - (59%)
• Gaps: 94/926 - (10%)

  Fly    16 RLDYDLMMAEEYILSDVEKNFILSCERGDLPGVKKILEEYQGTDKFNINCTDPMNRSALISAIEN 80
            |:...::.||.. ||..||.::.:.|:||...|||.|||.:...|.||||.||:.|:||:.||||
  Rat    17 RIPLRIVRAESE-LSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIEN 80

  Fly    81 ENFDLMVILLEHNIEVGDALLHAISEEYVEAVEELLQWEETNHKEGQPYSWEAV-----DRSKST 140
            ||.:|:.:||..|:.|||||||||.:|.|.|||.||     |||  :|...:.|     |:..|.
  Rat    81 ENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLL-----NHK--KPSGEKQVPPILLDKQFSE 138

  Fly   141 FTVDITPLILAAHRNNYEILKILLDRGATLPMPHDVKCGCDECVTSQMTDSLRHSQSRINAYRAL 205
            ||.||||:|||||.|||||:|:|:.:|.::|.||:|:|.|.|||:|...||||||:||:|.|:||
  Rat   139 FTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKAL 203

  Fly   206 SASSLIALSSRDPVLTAFQLSWELKRLQAMESEFRAEYTEMRQMVQDFGTSLLDHARTSMELEVM 270
            ::.|||||||.||.||||||||||:.|..:|:||::||.|:.:..:.|...|||..|:|.|||::
  Rat   204 ASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEII 268

  Fly   271 LNFNHEPSHDIWCLGQRQT---LERLKLAIRYKQKTFVAHPNVQQLLAAIWYDGLPGFRRKQASQ 332
            ||:..:.|     |.:.|:   |.||||||:|:||.|||.||.|||||:.|||..||:||:..:.
  Rat   269 LNYRDDNS-----LIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAV 328

  Fly   333 QLMDVVKLGCSFPIYSLKYILAPDSEGAKFMRKPFVKFITHSCSYMFFLMLLGAASLRVVQITFE 397
            :::....:|..||::|:.|::||.|....|:||||:|||.|:.||:.||.||..||..:.:...
  Rat   329 KMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDL- 392

  Fly   398 LLAFPWMLTMLEDWRKHERGSLPGPIELAIITYIMALIFEELKSLYSDGLFEYIMDLWNIVDYIS 462
                            :.:|..|..:|..|:.:::..|:.|:|.::..||.:||.|.||::|::.
  Rat   393 ----------------NRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVM 441

  Fly   463 NMFYVTWILCRATAWVIVHRDLWFRGIDPYFPREHWHPFDPMLLSEGAFAAGMVFSYLKLVHIFS 527
            |..|:..|..:..|:|      .:..::   |||.|..:.|.|::|..||...:||.|:|:.:|:
  Rat   442 NSLYLATISLKIVAFV------KYSALN---PRESWDMWHPTLVAEALFAIANIFSSLRLISLFT 497

  Fly   528 INPHLGPLQVSLGRMIIDIIKFFFIYTLVLFAFGCGLNQLLWYYAELEKNKCYHLHPDVADFDDQ 592
            .|.||||||:|||||::||:||.|||.|||.||..|||||.:||.|.:...|..:.     .:.|
  Rat   498 ANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLSCKGIR-----CEKQ 557

  Fly   593 EKACTIWRRFSNLFETSQSLFWASFGLVDLVSFDLAGIKSFTRFWALLMFGSYSVINIIVLLNML 657
            ..|      ||.||||.|||||:.|||::|...::.....||.|....|||:|:||:::||||||
  Rat   558 NNA------FSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNML 616

  Fly   658 IAMMSNSYQIISERADTEWKFARSQLWMSYFEDGGTIPPPFNLCPNMKML------------RKT 710
            ||||:||||:|::.||.||||||::|||||||:|||:|.|||:.|:.|.|            :|.
  Rat   617 IAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLVKWIWTHLCKKK 681

  Fly   711 LGRKRPSRTKSFMRKSMERAQTLH--DKVMKLLVRRYITAEQRR-RDDYGITEDDIIEVRQDISS 772
            : |::|....:..|::.:..:..|  .:||:.||:||:.|..|. :.:.|:||:::.|::|||||
  Rat   682 M-RRKPESFGTIGRRAADNLRRHHQYQEVMRNLVKRYVAAMIREAKTEEGLTEENVKELKQDISS 745

  Fly   773 LRFELLEIFTNNNWDV------------PDIEKKSQGVARTTKGKVMERRILKDFQIGFVENLKQ 825
            .|||:|.:...:....            .|.::||....   .|| .:|:.|..|.:..:.:.:.
  Rat   746 FRFEVLGLLRGSKLSTIQSANAASSASSADSDEKSHSEG---NGK-DKRKNLSLFDLTTLIHPRS 806

  Fly   826 EMSESESGRDIFSSLAKVIGRKKTQKGDKDWNAIARKNTFASDPIGSKRSSMQRHSQR--SLRRK 888
            .:..||  |...|:.:.::.::..::..:..|.:|....|......||:::.::::.:  |:..:
  Rat   807 AVIASE--RHNLSNGSALVVQEPPREKQRKVNFVADIKNFGLFHRRSKQNAAEQNANQIFSVSEE 869

  Fly   889 IIEQANEGLQMNQTQL 904
            |..|...|......||
  Rat   870 ITRQQAAGALERNIQL 885

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trp	NP_476768.1	trp	16..776	CDD:273311	348/782 (45%)
		ANK repeat	69..98	CDD:293786	14/28 (50%)
		ANK repeat	99..135	CDD:293786	18/40 (45%)
		ANK repeat	137..168	CDD:293786	19/30 (63%)
		TRP_CaM_bind1	797..860	CDD:467881	10/62 (16%)
		PRK12323	<891..1102	CDD:481241	4/14 (29%)
		PspC_subgroup_2	<1015..1156	CDD:468202
Trpc4	NP_536321.1	trp	17..749	CDD:273311	348/782 (45%)
		ANK 1. /evidence=ECO:0000250|UniProtKB:Q9UBN4	29..60		13/30 (43%)
		ANK 2. /evidence=ECO:0000250|UniProtKB:Q9UBN4	71..93		12/21 (57%)
		ANK 3. /evidence=ECO:0000250|UniProtKB:Q9UBN4	96..118		16/26 (62%)
		ANK repeat	122..167	CDD:293786	22/44 (50%)
		ANK 4. /evidence=ECO:0000250|UniProtKB:Q9UBN4	141..165		16/23 (70%)
		Interaction with ITPR1, ITPR2 and ITPR3. /evidence=ECO:0000250|UniProtKB:Q9UBN4	615..977		85/278 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	767..790		5/26 (19%)
		PDZ-binding domain. /evidence=ECO:0000250|UniProtKB:Q9UBN4	975..977