DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trp and TRPC6

DIOPT Version :10

Sequence 1:NP_476768.1 Gene:trp / 43542 FlyBaseID:FBgn0003861 Length:1275 Species:Drosophila melanogaster
Sequence 2:NP_004612.2 Gene:TRPC6 / 7225 HGNCID:12338 Length:931 Species:Homo sapiens


Alignment Length:924 Identity:298/924 - (32%)
Similarity:450/924 - (48%) Gaps:205/924 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 LSDVEKNFILSCERGDLPGVKKILEEYQGTDKFNINCTDPMNRSALISAIENENFDLMVILL--E 91
            ||..|:.|:.:.|.|::|.|:|:|||   ....|:||.|.|.::||..|:.||:.::..:||  |
Human    95 LSIEEERFLDAAEYGNIPVVRKMLEE---CHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKE 156

  Fly    92 HNIEVGDALLHAISEEYVEAVEELLQW----------EETNHKEGQPYSWEAVDRSKSTFTVDIT 146
            :...||||||.|||:.||..||.:|..          ...:..|.|...:.|.|...:.|:.|:|
Human   157 NLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVT 221

  Fly   147 PLILAAHRNNYEILKILLDRGATLPMPHDVKCGCDECVTSQMTDSLRHSQSRINAYRALSASSLI 211
            |:|||||...|||:..||.:||.:..|||..|.|::|...|..||..||:||||||:.|::.:.:
Human   222 PIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYL 286

  Fly   212 ALSSRDPVLTAFQLSWELKRLQAMESEFRAEYTEMRQMVQDFGTSLLDHARTSMELEVMLNFNHE 276
            :|||.|||:||.:||.||..|..:|.||:.:|.::....:||...|||..|.:.|:|.:||.:.|
Human   287 SLSSEDPVMTALELSNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVE 351

  Fly   277 P----SHDIWCLGQRQTLERLKLAIRYKQKTFVAHPNVQQLLAAIWYDGLPGFRRKQASQQLMDV 337
            .    .|.      |..|.||||||:|:.|.||||||.||.|.:|||:.|.|.|::..:.:.:.|
Human   352 TLQSGDHG------RPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVV 410

  Fly   338 VKLGCSFPIYSLKYILAPDSEGAKFMRKPFVKFITHSCSYMFF--LMLLGAASLRVVQITFE--- 397
            :.:....|..:|.|..||.|:..|.||.||:||:.|:.|:..|  |:::.||.      .||   
Human   411 LAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAAD------RFEGTK 469

  Fly   398 LL------------------AFPWMLTMLEDWRKHERGSLPGPIELAIITYIMALIFEELKSLYS 444
            ||                  .|.||                   |:.||::::.:|:.|.|.:::
Human   470 LLPNETSTDNAKQLFRMKTSCFSWM-------------------EMLIISWVIGMIWAECKEIWT 515

  Fly   445 DGLFEYIMDLWNIVDYISNMFYVTWILCRATAWVIVHRDLWFRG-----ID-------------- 490
            .|..||:.:|||::|:.....:....:.|..|:       |...     ||              
Human   516 QGPKEYLFELWNMLDFGMLAIFAASFIARFMAF-------WHASKAQSIIDANDTLKDLTKVTLG 573

  Fly   491 ---PYF--PREHWHPFDPMLLSEGAFAAGMVFSYLKLVHIFSINPHLGPLQVSLGRMIIDIIKFF 550
               .|:  .|..|.|.||.::|||.:|..:|.|:.::.:|...|...||||:||||.:.||.||.
Human   574 DNVKYYNLARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFM 638

  Fly   551 FIYTLVLFAFGCGLNQLLWYYAELEKNKCYHLHPDVADFDDQEKACTIWRRFSNLFETSQSLFWA 615
            .|:.:|..||..|:..|..||...::|:.                      |:.:.|:.::||||
Human   639 VIFIMVFVAFMIGMFNLYSYYIGAKQNEA----------------------FTTVEESFKTLFWA 681

  Fly   616 SFGLVDLVSFDLAGIKSFTRFWALLMFGSYSVINIIVLLNMLIAMMSNSYQIISERADTEWKFAR 680
            .|||.::.|..:.....|......:::|.|:|..:||||||||||:::|:|.|.:.||.||||||
Human   682 IFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFAR 746

  Fly   681 SQLWMSYFEDGGTIPPPFNLCPNMKML---------------------------------RKTLG 712
            ::||.||||:|.|:|.||||.|:.|.|                                 .|.||
Human   747 AKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWISELFQGHKKGFQEDAEMNKINEEKKLG 811

  Fly   713 --------------------RKRPS--RTKSFMRKSMERAQTLHDKVMKLLVRRYITAEQRRRDD 755
                                .|:||  .::.|...|.......:.|:||.|::||:...|..::.
Human   812 ILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFHLNSFNNPPRQYQKIMKRLIKRYVLQAQIDKES 876

  Fly   756 YGITEDDIIEVRQDISSLRFELLEIFTNNNWDVPDIEKKSQGVARTTKGKVMERRILKDFQIGFV 820
            ..:.|.::.|::|||||||:||||..:.|..|:.::.:                      ::|  
Human   877 DEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIR----------------------ELG-- 917

  Fly   821 ENLKQEMSESESGR 834
            |.|..|.::.|:.|
Human   918 EKLSMEPNQEETNR 931

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trpNP_476768.1 trp 16..776 CDD:273311 286/864 (33%)
ANK repeat 69..98 CDD:293786 10/30 (33%)
ANK repeat 99..135 CDD:293786 14/45 (31%)
ANK repeat 137..168 CDD:293786 14/30 (47%)
TRP_CaM_bind1 797..860 CDD:467881 6/38 (16%)
PRK12323 <891..1102 CDD:481241
PspC_subgroup_2 <1015..1156 CDD:468202
TRPC6NP_004612.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
trp 82..897 CDD:273311 286/864 (33%)
ANK 1 97..126 10/31 (32%)
ANK 2 132..161 9/28 (32%)
ANK repeat 132..159 CDD:293786 9/26 (35%)
ANK repeat 161..185 CDD:293786 14/23 (61%)
ANK 3 163..189 12/25 (48%)
ANK repeat 212..247 CDD:293786 16/34 (47%)
ANK 4 218..247 15/28 (54%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.