Protein Alignment trp and TRPC3

DIOPT Version :10

• Sequence 1: NP_476768.1
• Gene: trp / 43542
• FlyBaseID: FBgn0003861
• Length: 1275
• Species: Drosophila melanogaster
• Sequence 2: XP_011530519.1
• Gene: TRPC3 / 7222
• HGNCID: 12335
• Length: 937
• Species: Homo sapiens
• Alignment Length: 850
• Identity: 284/850 - (33%)
• Similarity: 445/850 - (52%)
• Gaps: 148/850 - (17%)

  Fly    29 LSDVEKNFILSCERGDLPGVKKILEEYQGTDKFNINCTDPMNRSALISAIENENFDLMVILL--E 91
            |:..|:.|:.:.|.|::|.|:|:|||   :...|:||.|.|.::||..|:.||:.::..:||  |
Human   109 LTAEEERFLDAAEYGNIPVVRKMLEE---SKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKE 170

  Fly    92 HNIEVGDALLHAISEEYVEAVEELLQWEETNH---------------KEGQPYSWEAVDRSKSTF 141
            :...:|||||.|||:.||..||.:|     ||               :|.|...:.|.|...:.|
Human   171 NLARIGDALLLAISKGYVRIVEAIL-----NHPGFAASKRLTLSPCEQELQDDDFYAYDEDGTRF 230

  Fly   142 TVDITPLILAAHRNNYEILKILLDRGATLPMPHDVKCGCDECVTSQMTDSLRHSQSRINAYRALS 206
            :.||||:|||||...||::.:||.:||.:..|||..|.|.:|:..|..||..||:||||||:.|:
Human   231 SPDITPIILAAHCQKYEVVHMLLMKGARIERPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLA 295

  Fly   207 ASSLIALSSRDPVLTAFQLSWELKRLQAMESEFRAEYTEMRQMVQDFGTSLLDHARTSMELEVML 271
            :.:.::|||.||||||.:||.||.:|..:|.||:.:|.::....:||...:||..|.|.|:|.:|
Human   296 SPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAIL 360

  Fly   272 NFNHEPSHDIWCLGQRQTLERLKLAIRYKQKTFVAHPNVQQLLAAIWYDGLPGFRRKQASQQLMD 336
            |.:.|.:..:.....:.:|.|:||||:|:.|.||||||.||.|..|||:.|.|.|.:..:.:.:.
Human   361 NGDLESAEPLEVHRHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLV 425

  Fly   337 VVKLGCSFPIYSLKYILAPDSEGAKFMRKPFVKFITHSCSYMFFLMLL---------GAASLRVV 392
            |:.:....|..::.|.:||.|...|.:|.||:||:.|:.|::.||.||         |..:|..:
Human   426 VLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNI 490

  Fly   393 QIT--------FELLAFPWMLTMLEDWRKHERGSLPGPIELAIITYIMALIFEELKSLYSDGLFE 449
            .:|        .:...|.|                   .|:.|:.:::.:::.|.|.|:.:|..|
Human   491 TVTDYPKQIFRVKTTQFTW-------------------TEMLIMVWVLGMMWSECKELWLEGPRE 536

  Fly   450 YIMDLWNIVDYISNMFYVTWILCRATAWV------------IVHRDLWFRGIDP---YF--PREH 497
            ||:.|||::|:.....::.....|..|::            :...||....:.|   ||  .|:.
Human   537 YILQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSYVQESDLSEVTLPPEIQYFTYARDK 601

  Fly   498 WHPFDPMLLSEGAFAAGMVFSYLKLVHIFSINPHLGPLQVSLGRMIIDIIKFFFIYTLVLFAFGC 562
            |.|.||.::|||.:|..:|.|:.::.:|...|...||||:||||.:.||.||..::.:|.|||..
Human   602 WLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMI 666

  Fly   563 GLNQLLWYYAELEKNKCYHLHPDVADFDDQEKACTIWRRFSNLFETSQSLFWASFGLVDLVSFDL 627
            |:..|..||...:.|..                      |:.:.|:.::|||:.|||.::.|..|
Human   667 GMFILYSYYLGAKVNAA----------------------FTTVEESFKTLFWSIFGLSEVTSVVL 709

  Fly   628 AGIKSFTRFWALLMFGSYSVINIIVLLNMLIAMMSNSYQIISERADTEWKFARSQLWMSYFEDGG 692
            .....|......:::|.|:|..::|||||||||:::|||.|.:.:|.|||||||:||:|||:||.
Human   710 KYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGK 774

  Fly   693 TIPPPFNLCPNMK------------------MLRKT----LGRKRPSRTKSF------MRK---- 725
            |:||||:|.|:.|                  .|:|.    :|..:...||.|      |::
Human   775 TLPPPFSLVPSPKSFVYFIMRIVNFPKCRRRRLQKDIEMGMGNSKSRFTKCFPVHLNLMQRCELN 839

  Fly   726 ----------------SMERAQTLHDKVMKLLVRRYITAEQRRRDDYGITEDDIIEVRQDISSLR 774
                            |:....|.:.::||.|::||:...|..:::..:.|.::.|::|||||||
Human   840 LFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLR 904

  Fly   775 FELLE 779
            :||||
Human   905 YELLE 909

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trp	NP_476768.1	trp	16..776	CDD:273311	280/845 (33%)
		ANK repeat	69..98	CDD:293786	9/30 (30%)
		ANK repeat	99..135	CDD:293786	16/50 (32%)
		ANK repeat	137..168	CDD:293786	14/30 (47%)
		TRP_CaM_bind1	797..860	CDD:467881
		PRK12323	<891..1102	CDD:481241
		PspC_subgroup_2	<1015..1156	CDD:468202
TRPC3	XP_011530519.1	trp	96..906	CDD:273311	280/845 (33%)
		ANK repeat	146..177	CDD:293786	9/30 (30%)
		ANK repeat	226..261	CDD:293786	16/34 (47%)