DRSC/TRiP Functional Genomics Resources

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Protein Alignment trp and TRPC1

DIOPT Version :10

Sequence 1:NP_476768.1 Gene:trp / 43542 FlyBaseID:FBgn0003861 Length:1275 Species:Drosophila melanogaster
Sequence 2:NP_001238774.1 Gene:TRPC1 / 7220 HGNCID:12333 Length:793 Species:Homo sapiens


Alignment Length:788 Identity:286/788 - (36%)
Similarity:440/788 - (55%) Gaps:83/788 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 EEYILSDVEKNFILSCERGDLPGVKKILEEYQGTDKFNINCTDPMNRSALISAIENENFDLMVIL 89
            ||..|:  ||.|:|:|::||...|||||||....| .||||.|.:.|:|:...|||||.|::.:|
Human    42 EENTLN--EKLFLLACDKGDYYMVKKILEENSSGD-LNINCVDVLGRNAVTITIENENLDILQLL 103

  Fly    90 LEHNIEVGDALLHAISEEYVEAVEELLQWEETNH---KEGQPYSWEAVDRSKS---TFTVDITPL 148
            |::..:..||||.||..|.|.||:.||     ||   :..:|...:.::|.::   :.|:|:.|:
Human   104 LDYGCQSADALLVAIDSEVVGAVDILL-----NHRPKRSSRPTIVKLMERIQNPEYSTTMDVAPV 163

  Fly   149 ILAAHRNNYEILKILLDRGATLPMPHDVKCGCDECVTSQMTDSLRHSQSRINAYRALSASSLIAL 213
            ||||||||||||.:||.:..:||.||.|.|.|..|......||||||:.|::.||.|::.:||.|
Human   164 ILAAHRNNYEILTMLLKQDVSLPKPHAVGCECTLCSAKNKKDSLRHSRFRLDIYRCLASPALIML 228

  Fly   214 SSRDPVLTAFQLSWELKRLQAMESEFRAEYTEMRQMVQDFGTSLLDHARTSMELEVMLNF--NHE 276
            :..||:|.||:||.:||.|..:|.|||.:|.|:.:..:.|...||..||.|.||||:||.  :.|
Human   229 TEEDPILRAFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQARNSRELEVILNHTSSDE 293

  Fly   277 PSHDIWCLGQRQTLERLKLAIRYKQKTFVAHPNVQQLLAAIWYDGLPGFRRKQASQQLMDVVKLG 341
            |......|.:|..|.||||||:|.||.||:..|.||.|..:|:..:.|:|||...:::|.|:.:|
Human   294 PLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTVWFGQMSGYRRKPTCKKIMTVLTVG 358

  Fly   342 CSFPIYSLKYILAPDSEGAKFMRKPFVKFITHSCSYMFFLMLLGAASLRVVQITFELLAFPWMLT 406
            ..:|:.||.|::||.|:..:.:..||:|||.|..||..||:||...||                 
Human   359 IFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASYFTFLLLLNLYSL----------------- 406

  Fly   407 MLEDWRKHERGSLPGPIELAIITYIMALIFEELKSLYSDGLFEYIMDLWNIVDYISNMFYVTWIL 471
            :..:.:|:..|.....|:..:|.:|:.:|:.::|.|:.:||.:::.:..|.:.::.|..|:....
Human   407 VYNEDKKNTMGPALERIDYLLILWIIGMIWSDIKRLWYEGLEDFLEESRNQLSFVMNSLYLATFA 471

  Fly   472 CRATAWVIVHRDLWFRGIDPYFPREHWHPFDPMLLSEGAFAAGMVFSYLKLVHIFSINPHLGPLQ 536
            .:    |:.|..     ...:..|:.|..|.|.|::||.||...|.|||:|..:::.:..|||||
Human   472 LK----VVAHNK-----FHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQ 527

  Fly   537 VSLGRMIIDIIKFFFIYTLVLFAFGCGLNQLLWY---YAELEKNKCYHLHPDVADFDDQEKACTI 598
            :|:|:|:.|..||..::.||||:|..||.||  |   |...|:..|      |..|.:|:...| 
Human   528 ISMGQMLQDFGKFLGMFLLVLFSFTIGLTQL--YDKGYTSKEQKDC------VGIFCEQQSNDT- 583

  Fly   599 WRRFSNLFETSQSLFWASFGLVDLVSFDLAGIKSFT------RFWALLMFGSYSVINIIVLLNML 657
               |.:...|..:|||..|.|..:..|    :..|:      .|...::.|:|:|:.:|||..:|
Human   584 ---FHSFIGTCFALFWYIFSLAHVAIF----VTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLL 641

  Fly   658 IAMMSNSYQIISERADTEWKFARSQLWMSYFEDGGTIPPPFNLCPNMKML-------------RK 709
            :||:..|:|:|:...|.||||||::||:|||:|..|:|||||:.|:.|.:             ..
Human   642 VAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWICSHT 706

  Fly   710 TLGR-KRPSRTKSFMRKSMERAQTLHDKVMKLLVRRYITA-EQRRRDDYGITEDDIIEVRQDISS 772
            :.|: ||.:..|.:.....:|.:. :.|||..||.||:|: .|:.:.....|.:::.|:|||:|.
Human   707 SKGKVKRQNSLKEWRNLKQKRDEN-YQKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLSK 770

  Fly   773 LRFELLEI 780
            .|.|:.::
Human   771 FRNEIRDL 778

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trpNP_476768.1 trp 16..776 CDD:273311 285/782 (36%)
ANK repeat 69..98 CDD:293786 10/28 (36%)
ANK repeat 99..135 CDD:293786 14/38 (37%)
ANK repeat 137..168 CDD:293786 17/33 (52%)
TRP_CaM_bind1 797..860 CDD:467881
PRK12323 <891..1102 CDD:481241
PspC_subgroup_2 <1015..1156 CDD:468202
TRPC1NP_001238774.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30
ANK 1. /evidence=ECO:0000269|PubMed:39478185, ECO:0007744|PDB:8WPL, ECO:0007744|PDB:8WPM 46..75 16/31 (52%)
TRPV 48..774 CDD:454755 282/774 (36%)
ANK 2. /evidence=ECO:0000269|PubMed:39478185, ECO:0007744|PDB:8WPL, ECO:0007744|PDB:8WPM 83..109 10/25 (40%)
ANK 3. /evidence=ECO:0000269|PubMed:39478185, ECO:0007744|PDB:8WPL, ECO:0007744|PDB:8WPM 111..156 16/49 (33%)
ANK 4. /evidence=ECO:0000269|PubMed:39478185, ECO:0007744|PDB:8WPL, ECO:0007744|PDB:8WPM 158..180 15/21 (71%)
Blue background indicates that the domain is not in the aligned region.

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