DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trp and trpc1

DIOPT Version :9

Sequence 1:	NP_476768.1	Gene:	trp / 43542	FlyBaseID:	FBgn0003861	Length:	1275	Species:	Drosophila melanogaster
Sequence 2:	NP_001185590.1	Gene:	trpc1 / 570841	ZFINID:	ZDB-GENE-070830-1	Length:	796	Species:	Danio rerio

Alignment Length:	825	Identity:	289/825 - (35%)
Similarity:	450/825 - (54%)	Gaps:	106/825 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SRLDYDL--MMA-----------EEYI-LSDV----------EKNFILSCERGDLPGVKKILEEY 55
            |.|.|.|  :||           ::|: |.||          ||.|:|:||:||...|||:|||
Zfish     4 SALPYSLSVIMAALYQGTDSSSPDKYLALKDVREVKEETTLDEKLFLLACEKGDYYMVKKLLEE- 67

  Fly    56 QGTDKFNINCTDPMNRSALISAIENENFDLMVILLEHNIEVGDALLHAISEEYVEAVEELLQWEE 120
            :...:.||||.|.:.|.|:..:|||||.|::.:||:|..:..||||.||..|.|.||:.||
Zfish    68 KRHGELNINCVDVLGRDAVTISIENENLDILQLLLDHGCQATDALLVAIDSEVVGAVDILL---- 128

  Fly   121 TNH---KEGQPYSWEAVDRSKS---TFTVDITPLILAAHRNNYEILKILLDRGATLPMPHDVKCG 179
             ||   :..:|...:.:.:.::   :.|:|:.|:||||||||||||.:||.:..:||.||.|.|.
Zfish   129 -NHRPRRSSKPSIAKLIQKIQNPEYSTTMDVAPVILAAHRNNYEILTMLLKQDISLPRPHAVGCE 192

  Fly   180 CDECVTSQMTDSLRHSQSRINAYRALSASSLIALSSRDPVLTAFQLSWELKRLQAMESEFRAEYT 244
            |..|......||||||:.|::.||.|::.|||.|:..||:|.||:||.:||.|..:|.|||.:|.
Zfish   193 CTLCNAKNKKDSLRHSRFRLDIYRCLASPSLIMLTEEDPILRAFELSADLKELSLVEVEFRNDYE 257

  Fly   245 EMRQMVQDFGTSLLDHARTSMELEVMLNFNHEPSHD----IWCLGQRQTLERLKLAIRYKQKTFV 305
            |:.:..:.|...||.|||.|.||||:|  ||..|.|    ...|.:|..|.||||||:|.||.||
Zfish   258 ELAKQCKMFAKDLLAHARNSRELEVIL--NHTSSEDHVDKRGFLEERMNLSRLKLAIKYNQKEFV 320

  Fly   306 AHPNVQQLLAAIWYDGLPGFRRKQASQQLMDVVKLGCSFPIYSLKYILAPDSEGAKFMRKPFVKF 370
            |..|.||.|..:|:..:..:|||....:::.|:.:...:|:.|:.|:|.|.|...:.:..||:||
Zfish   321 AQSNCQQFLNTVWFGEMASYRRKHTCLKIVSVLSVALLWPLLSICYLLGPRSRVGQVIHTPFIKF 385

  Fly   371 ITHSCSYMFFLMLLGAASLRVVQITFELLAFPWMLTMLEDWRKHERGSLPGPIELAIITYIMALI 435
            |.||.||..||:||...||                  :.:.:|:...:|.. |:..:|.:|:.::
Zfish   386 IIHSASYFTFLLLLNLYSL------------------IYNDKKNMAPALQF-IDYLLILWIIGMV 431

  Fly   436 FEELKSLYSDGLFEYIMDLWNIVDYISNMFYVTWILCRAT-AWVIVHRDLWFRGIDPYFPREHWH 499
            :.::|.|:.:||.:::.:..|.:.::.|..|:      || |..||..:.:.:.|.|. .|:.|.
Zfish   432 WSDVKRLWYEGLEDFLEESRNQLSFVMNSLYL------ATFALKIVAHNKYSKIIKPE-ERKEWD 489

  Fly   500 PFDPMLLSEGAFAAGMVFSYLKLVHIFSINPHLGPLQVSLGRMIIDIIKFFFIYTLVLFAFGCGL 564
            .|.|.|::||.||..:|.|||:|..:::.:..|||||:|:|:|:.:..||..::.|||.:|..||
Zfish   490 AFHPTLVAEGLFAFAIVLSYLRLFFMYTTSSILGPLQISMGQMLQEFGKFLGLFLLVLISFTIGL 554

  Fly   565 NQLLWYYAELEKNKCYHLHPDVADFDDQEKACT-IWRR------FSNLFETSQSLFWASFGL--V 620
            .||            |....|.:...|..|.|. |:.:      |.....|..:|||..|.|  |
Zfish   555 TQL------------YGKDQDPSKTKDDNKDCEGIYCQQQSNDTFHTFMGTCYALFWYIFSLAHV 607

  Fly   621 DLVSFDLAGIKSFTRFWALLMFGSYSVINIIVLLNMLIAMMSNSYQIISERADTEWKFARSQLWM 685
            :|....::..:....|...|:.|:|:::.:|||..:|:||:..|::.|:...|.||||||::||:
Zfish   608 NLFVTRISYTEELRSFVGALIVGTYNIVVVIVLTKLLVAMLHKSFRQIANHEDKEWKFARAKLWL 672

  Fly   686 SYFEDGGTIPPPFNLCPNMKML-------------RKTLGR-KRPSRTKSFMRKSMERAQTLHDK 736
            |||:|..|:|||||:.|:.|.:             ..:.|: ||.:..:.:.....:|.|. :.|
Zfish   673 SYFDDKCTLPPPFNVLPSPKTVCYLVISMSKWICSHTSTGKVKRQNSLREWTNLKQKRDQN-YQK 736

  Fly   737 VMKLLVRRYITAEQRRRDDYG-ITEDDIIEVRQDISSLRFELLEI 780
            :|..||.||:|:.:::..... .|.:::.::|||:|..|.|:.::
Zfish   737 IMCCLVHRYLTSTRQKMQSMDQATVENLNDLRQDLSKFRNEMRDL 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trp	NP_476768.1	trp	16..776	CDD:273311	287/818 (35%)
		ANK	64..>168	CDD:238125	46/109 (42%)
		ANK repeat	69..98	CDD:293786	11/28 (39%)
		ANK repeat	99..135	CDD:293786	14/38 (37%)
		ANK repeat	137..168	CDD:293786	17/33 (52%)
		TRP_2	178..236	CDD:285535	27/57 (47%)
		BASP1	938..1158	CDD:283191
trpc1	NP_001185590.1	trp	46..777	CDD:273311	278/777 (36%)
		ANK	49..177	CDD:238125	58/133 (44%)
		ANK repeat	81..110	CDD:293786	11/28 (39%)
		TRP_2	191..249	CDD:285535	27/57 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581923
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D824310at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102173
Panther	1	1.100	-	-	O	PTHR10117
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850