DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trp and trpc7a

DIOPT Version :9

Sequence 1:	NP_476768.1	Gene:	trp / 43542	FlyBaseID:	FBgn0003861	Length:	1275	Species:	Drosophila melanogaster
Sequence 2:	NP_001276808.1	Gene:	trpc7a / 567566	ZFINID:	ZDB-GENE-091113-40	Length:	842	Species:	Danio rerio

Alignment Length:	866	Identity:	294/866 - (33%)
Similarity:	446/866 - (51%)	Gaps:	149/866 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LSDVEKNFILSCERGDLPGVKKILEEYQGTDKFNINCTDPMNRSALISAIENENFDLMVILL--E 91
            |::.|:.|:.:.|.|::|.|:|:|||   :...|:||.|.|.::||..|:.||:.::..:||  |
Zfish    31 LTEEEERFLDAAEYGNIPSVRKMLEE---SKTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKE 92

  Fly    92 HNIEVGDALLHAISEEYVEAVEELLQWEETNHK--EG------QPYSWE-------AVDRSKSTF 141
            ....||||||.|||:.||..||.:|.     |.  ||      .|...|       |.|...:.|
Zfish    93 GLARVGDALLLAISKGYVRIVEAILA-----HPAFEGGLRLTLSPLEQELRDDDFYAYDEDGTRF 152

  Fly   142 TVDITPLILAAHRNNYEILKILLDRGATLPMPHDVKCGCDECVTSQMTDSLRHSQSRINAYRALS 206
            :.||||:|||||...|||:.|||.:||.:..|||..|.|.||...|..||..||:||:|||:.|:
Zfish   153 SQDITPMILAAHCKEYEIVHILLLKGARIEKPHDYFCKCGECAEKQKQDSFSHSRSRMNAYKGLA 217

  Fly   207 ASSLIALSSRDPVLTAFQLSWELKRLQAMESEFRAEYTEMRQMVQDFGTSLLDHARTSMELEVML 271
            :::.::|||.||||||.:||.||.:|..:|:||:.:|.::....:||...:||..|.:.|:|.:|
Zfish   218 SAAYLSLSSEDPVLTALELSNELAQLANIETEFKNDYRKLSMQCKDFVVGVLDLCRNTEEVEAIL 282

  Fly   272 N----FNHEPSHDIWCLGQRQTLERLKLAIRYKQKTFVAHPNVQQLLAAIWYDGLPGFRRKQASQ 332
            |    .||...|      .|..|.|:||||:|:.|.||||||.||.|..:||:.|.|.|::....
Zfish   283 NGDVDQNHPSEH------HRPCLSRVKLAIKYEVKKFVAHPNCQQRLLTLWYENLSGLRQQSIGV 341

  Fly   333 QLMDVVKLGCSFPIYSLKYILAPDSEGAKFMRKPFVKFITHSCSYMFFLMLL---------GAAS 388
            :...|:.:....|..::.|.:.|.|:..:.:|.||:||:.|:.|:..||.||         |..:
Zfish   342 KCWTVLGVMVGLPFLAIAYWIMPFSKVGQVLRSPFMKFVAHAVSFTLFLCLLVLNASDRFAGVKT 406

  Fly   389 LRVVQIT--------FELLAFPWMLTMLEDWRKHERGSLPGPIELAIITYIMALIFEELKSLYSD 445
            |....||        .:...|.|                   .|:.|:.:::.:|:.|.|.:::|
Zfish   407 LPNETITDHPRQIFRIKTTQFSW-------------------TEMLIMKWVLGMIWTECKEVWAD 452

  Fly   446 GLFEYIMDLWNIVDYISNMFYVTWILCRATAWV-----IVHRDLWFRGID----------PYF-- 493
            |..||||.|||::|:.....:|.....|..|::     .::.||:....|          .||
Zfish   453 GPREYIMHLWNVLDFGMLSVFVASFTARLMAFLQASQAQLYVDLYVTNADLINASLPADVAYFTY 517

  Fly   494 PREHWHPFDPMLLSEGAFAAGMVFSYLKLVHIFSINPHLGPLQVSLGRMIIDIIKFFFIYTLVLF 558
            .|..|.|.||.|:|||.::..:|.|:.::.::...|...||||:||||.:.||.||..|:.:|..
Zfish   518 ARNRWLPSDPQLISEGLYSIAVVLSFSRIAYVLPANESFGPLQISLGRTVKDIFKFMVIFIMVFL 582

  Fly   559 AFGCGLNQLLWYYAELEKNKCYHLHPDVADFDDQEKACTIWRRFSNLFETSQSLFWASFGLVDLV 623
            ||..|:..|..||...:.|..                      |:.:.|:.::|||:.|||.:::
Zfish   583 AFMIGMFNLYSYYLGAKYNPA----------------------FTTVEESFKTLFWSIFGLSEVI 625

  Fly   624 SFDLAGIKSFTRFWALLMFGSYSVINIIVLLNMLIAMMSNSYQIISERADTEWKFARSQLWMSYF 688
            |..|.....|......:::|.|:|..::|||||||||:::|||.|.|.||.||||||::||:|||
Zfish   626 SVVLKYDHKFIENIGYILYGVYNVTMVVVLLNMLIAMINHSYQEIEEDADVEWKFARAKLWLSYF 690

  Fly   689 EDGGTIPPPFNLCPNMKML---------------------------------RKTLGRKRPSRT- 719
            ::|.|:|.||||.|:.|..                                 |..|.|.||..:
Zfish   691 DEGSTLPAPFNLIPSPKSFYYMAQRTKACLVSLCKARVRSNSSQQDMGMANSRSKLYRFRPYHSQ 755

  Fly   720 KSFMRKSMERAQTLHDKVMKLLVRRYITAEQRRRDDYGITEDDIIEVRQDISSLRFELLEIFTNN 784
            :.|..::..:..|.:.|:||.|::||:...|...:...|.|.::.|::|||||||:||||..:..
Zfish   756 EGFTVRNPIKHPTRYQKLMKRLIKRYVLKAQIDSESNEINEGELKEIKQDISSLRYELLEEKSQA 820

  Fly   785 NWDVPDI-----EKKSQGVAR 800
            ..::.::     :|.|:|..|
Zfish   821 TEELAELIQELGDKLSKGNKR 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trp	NP_476768.1	trp	16..776	CDD:273311	286/835 (34%)
		ANK	64..>168	CDD:238125	49/120 (41%)
		ANK repeat	69..98	CDD:293786	10/30 (33%)
		ANK repeat	99..135	CDD:293786	17/50 (34%)
		ANK repeat	137..168	CDD:293786	16/30 (53%)
		TRP_2	178..236	CDD:285535	29/57 (51%)
		BASP1	938..1158	CDD:283191
trpc7a	NP_001276808.1	trp	18..812	CDD:273311	286/835 (34%)
		ANK	41..175	CDD:238125	56/141 (40%)
		ANK repeat	68..99	CDD:293786	10/30 (33%)
		ANK repeat	100..146	CDD:293786	17/50 (34%)
		ANK repeat	148..182	CDD:293786	18/33 (55%)
		TRP_2	189..247	CDD:285535	29/57 (51%)
		FTSW_RODA_SPOVE	573..>656	CDD:294347	25/104 (24%)
		PCRF	767..>837	CDD:305100	23/69 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910