DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trp and trpc6a

DIOPT Version :9

Sequence 1:	NP_476768.1	Gene:	trp / 43542	FlyBaseID:	FBgn0003861	Length:	1275	Species:	Drosophila melanogaster
Sequence 2:	XP_005161247.1	Gene:	trpc6a / 563989	ZFINID:	ZDB-GENE-040724-114	Length:	874	Species:	Danio rerio

Alignment Length:	853	Identity:	298/853 - (34%)
Similarity:	452/853 - (52%)	Gaps:	130/853 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LSDVEKNFILSCERGDLPGVKKILEEYQGTDKFNINCTDPMNRSALISAIENENFDLMVILLEHN 93
            |:.:|:.|:.:.|.|::|.|:::|||....|   :||.|.|.::||..|:.||:.::..:||:.:
Zfish    78 LTPLEERFLDAAEYGNIPVVRRMLEELPELD---VNCVDYMGQNALQLAVANEHLEVTELLLKKD 139

  Fly    94 --IEVGDALLHAISEEYVEAVEELLQ---WEETNHKEGQPY------SWEAVDRSKSTFTVDITP 147
              ..:|||||.|||:.|...||.:|.   :.::......|.      .:.|.|...:.|:.|:||
Zfish   140 NLSRIGDALLLAISKGYTRIVEAILSHKAFADSRRLTASPSQAPMHDDFFAYDEDGTRFSHDVTP 204

  Fly   148 LILAAHRNNYEILKILLDRGATLPMPHDVKCGCDECVTSQMTDSLRHSQSRINAYRALSASSLIA 212
            :|||:|.:.|||:.|||.:||.:..|||..|.||.|...|..||..||:|||||||.|::.:.::
Zfish   205 VILASHCHEYEIVHILLGKGARIEQPHDYFCTCDTCNYHQKYDSFCHSRSRINAYRGLASPAYLS 269

  Fly   213 LSSRDPVLTAFQLSWELKRLQAMESEFRAEYTEMRQMVQDFGTSLLDHARTSMELEVMLNFNHEP 277
            ||:.||||.|.:||.||..|..:|.||:.||.::....:||...|||..|::.|:|.:||...:
Zfish   270 LSNEDPVLAALELSNELASLANIEKEFKNEYRKLSMQCKDFVVGLLDLCRSTEEVEAILNGEED- 333

  Fly   278 SHDIWCLGQRQTLERLKLAIRYKQKTFVAHPNVQQLLAAIWYDGLPGFRRKQASQQLMDVVKLGC 342
              |...|..|.:|.||||||:|:.|.||||||.||.|.:|||:.||..|::..:.:.:.|:.:..
Zfish   334 --DTLELPGRPSLIRLKLAIKYELKKFVAHPNCQQQLLSIWYEHLPELRQQTTAIKFLVVLGVAM 396

  Fly   343 SFPIYSLKYILAPDSEGAKFMRKPFVKFITHSCSYMFFLMLL---------GAASLRVVQI---- 394
            ..|..::.|.:||.|:..|.||.||:||:.|:.|:..||.||         |...|..:.|
Zfish   397 GLPFLAMVYWVAPCSKMGKIMRGPFLKFVAHAASFTIFLGLLVMNAADRFDGTKLLPNMTIHDYP 461

  Fly   395 ----TFELLAFPWMLTMLEDWRKHERGSLPGPIELAIITYIMALIFEELKSLYSDGLFEYIMDLW 455
                ..:...|.||                   |:.||::::.:|:.|.|.::|.|..||:::.|
Zfish   462 TQLFRMKTTPFTWM-------------------EMLIISWVIGMIWAECKEIWSQGPREYLLEPW 507

  Fly   456 NIVDYISNMFYVTWILCRATA-WVIVHRDLWFRGIDP---------------YFPREH--WHPFD 502
            |::|:.....:|...:.|..| |   |.....|.:|.               ||.|..  |.|.|
Zfish   508 NLLDFGMLAIFVASFISRIMAFW---HASSAQRYVDEHYTDLTNVVLPFEVGYFQRARIDWLPSD 569

  Fly   503 PMLLSEGAFAAGMVFSYLKLVHIFSINPHLGPLQVSLGRMIIDIIKFFFIYTLVLFAFGCGLNQL 567
            |.|:|||.:|..:|.|:.::.:|...|...||||:||||.:.||.||..|:.||..||..|:..|
Zfish   570 PQLVSEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFILVFLAFMIGMFNL 634

  Fly   568 LWYYAELEKNKCYHLHPDVADFDDQEKACTIWRRFSNLFETSQSLFWASFGLVDLVSFDLAGIKS 632
            ..||...::|:.                      |:.:.|:.::||||.|||.::.|..:.....
Zfish   635 YSYYRGAKQNEA----------------------FTTVEESFKTLFWAIFGLSEVKSVVVNNGHK 677

  Fly   633 FTRFWALLMFGSYSVINIIVLLNMLIAMMSNSYQIISERADTEWKFARSQLWMSYFEDGGTIPPP 697
            |......:::|.|:|..:||||||||||::||:|.|.:.||.||||||::||.:|||:|.|:|.|
Zfish   678 FIENIGYVLYGVYNVTVVIVLLNMLIAMINNSFQEIEDDADVEWKFARAKLWFTYFEEGRTLPVP 742

  Fly   698 FNLCPNMK------MLRKTLGRKRPSRTKSFMRKS---------MERAQTL-----HDKVMKLLV 742
            |||.|:.|      |..|.|.|:...|.|:.|:.|         ..:|:||     :.|:||.||
Zfish   743 FNLIPSPKSVLSLVMGVKGLLRELSVRQKAIMKGSELSELGQSKTCQAKTLPRSSRYQKIMKRLV 807

  Fly   743 RRYITAEQRRRDDYGITEDDIIEVRQDISSLRFELLEIFTNNNWDVPDIEKKSQGVARTTK-GKV 806
            :|||...|..::...:.|.::.|::|||||||:|||             |:||..:....| .:.
Zfish   808 KRYIIKAQNDKECDEVNEGELKEIKQDISSLRYELL-------------EEKSHNMEELAKLVRT 859

  Fly   807 MERRILKD 814
            :|:.:.:|
Zfish   860 LEKNLSQD 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trp	NP_476768.1	trp	16..776	CDD:273311	289/812 (36%)
		ANK	64..>168	CDD:238125	40/114 (35%)
		ANK repeat	69..98	CDD:293786	8/30 (27%)
		ANK repeat	99..135	CDD:293786	12/44 (27%)
		ANK repeat	137..168	CDD:293786	14/30 (47%)
		TRP_2	178..236	CDD:285535	29/57 (51%)
		BASP1	938..1158	CDD:283191
trpc6a	XP_005161247.1	trp	65..841	CDD:273311	289/812 (36%)
		ANK repeat	76..113	CDD:293786	13/37 (35%)
		ANK	88..221	CDD:238125	46/135 (34%)
		ANK repeat	115..146	CDD:293786	8/30 (27%)
		ANK repeat	194..228	CDD:293786	16/33 (48%)
		TRP_2	235..294	CDD:285535	29/58 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3609
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	4	3.770