DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trp and trpc2a

DIOPT Version :9

Sequence 1:	NP_476768.1	Gene:	trp / 43542	FlyBaseID:	FBgn0003861	Length:	1275	Species:	Drosophila melanogaster
Sequence 2:	XP_017206723.1	Gene:	trpc2a / 559914	ZFINID:	ZDB-GENE-130530-602	Length:	855	Species:	Danio rerio

Alignment Length:	874	Identity:	255/874 - (29%)
Similarity:	426/874 - (48%)	Gaps:	124/874 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 ILSCERGDLPGVKKILEEYQGTDKFNINCTDPMNRSALISAIENENFDLMVILL---EHNI-EVG 97
            ||:.:.|::..|..:|....|..:......|.:.|.||..:|...:.|:|..||   :.:. ::.
Zfish    24 ILAIQEGNMAWVDSLLSLGDGIIRQLDESEDRLWREALNLSIRLGSEDIMTSLLLGVKFDFRQIH 88

  Fly    98 DALLHAI---SEEYVEAVEELLQWEETNHKEGQPYSWEAVDRS--KSTFTVDITPLILAAHRNNY 157
            :|||.|:   ...:|:.:.:.|..|:.|..:.:.:|....|.|  .|.|...:|||.||..::.|
Zfish    89 EALLVAVDTNQPRFVKHLLDRLDLEKGNKMDVRSFSMAIFDHSIDDSQFAPGVTPLTLACQKDLY 153

  Fly   158 EILKILLDRGATLPMPHDVKCGCDECVTSQMTDSLRHSQSRINAYRALSASSLIALSSRDPVLTA 222
            ||:.:|..||..:|:||.:.|.|.||...:..|.|:.|.||||.||.:::.:.::::|.|.:|:|
Zfish   154 EIVMMLTQRGHDIPLPHAISCTCLECNNGRQYDLLKFSLSRINTYRGIASRAYLSITSEDAMLSA 218

  Fly   223 FQLSWELKRLQAMESEFRAEYTEMRQMVQDFGTSLLDHARTSMELEVMLNFNHEPSHDIWCLGQR 287
            |.||.||::|...|.||:.:|..:.::.|:|...||...|...|:..:||.....|.|...  ..
Zfish   219 FHLSKELRKLSKKEPEFKPQYLALEELCQEFAVELLGMCRNQSEVSTILNSAEGDSEDEEL--DE 281

  Fly   288 QTLE-------RLKLAIRYKQKTFVAHPNVQQLLAAIWYDGLPGFRRKQASQQLMDVVKLGCSFP 345
            ||.|       ||:||:.|.||.||.||..||:|::||...|.|:|..:.:.:|:..:.:..:.|
Zfish   282 QTFEEGIPNLARLRLAVNYNQKQFVTHPICQQVLSSIWCGSLSGWRGSRTTWKLLVSLGIFLTMP 346

  Fly   346 IYSLKYILAPDSEGAKFMRKPFVKFITHSCSYMFFLMLLGAASLRVVQITFELLAFPWMLTMLED 410
            :..|.|.:||.|:..|.::.|.:||:.||.|||:||:.|...|:             :|.....:
Zfish   347 VLCLIYWIAPKSKLGKLLKVPVIKFLLHSASYMWFLIALLTESI-------------FMEIYRTE 398

  Fly   411 WRKHERGSLPGPIELAIITYIMALIFEELKSLYSDGLFEYIMDLWNIVDYISNMFYVTWILCRAT 475
            :....:..|...:.:   .::....:.|.|.::.:||..|.:|||||:|    |..::..|...|
Zfish   399 FASRNQNILHNSLHM---VWVAGFFWFECKEVWIEGLKSYFLDLWNILD----MMVLSMYLASFT 456

  Fly   476 AWVIVHRDLWF-------RGIDPYFP---REHWHPFDPMLLSEGAFAAGMVFSYLKLVHIFSINP 530
            ..:::....:|       :.:..||.   ||:|...||.|::|..||...:.|:.:|.:|...:.
Zfish   457 LRILIMLKGYFLCQDSSTQELCDYFTNTVRENWRQEDPQLIAETLFAVTSMLSFTRLAYILPAHE 521

  Fly   531 HLGPLQVSLGRMIIDIIKFFFIYTLVLFAFGCGLNQLLWYYAELEKNKCYHLHPDVADFDDQEKA 595
            .||.||:|:||||.|:::|.||..::..||.||:|.:...|
Zfish   522 SLGTLQISMGRMIDDMMRFMFILMIIGTAFLCGINNIYVPY------------------------ 562

  Fly   596 CTIWRRFSNLFETSQSLFWASFGL-----VDLVSFDLAGIKSFTRFWALLMFGSYSVINIIVLLN 655
             .|......|.||...|||..||:     ||:..:.||      .|...:.:|.::::.:|||||
Zfish   563 -VISPHLGRLNETFNFLFWTMFGMANQGYVDMPDYALA------EFVGRIFYGIFTLLIVIVLLN 620

  Fly   656 MLIAMMSNSYQIISERADTEWKFARSQLWMSYFEDGGTIPPPFNLCPNMK----MLRKTL----- 711
            |||||:|||:|.|.:.||.|||||||:|::|||.:|.|:|.|||:.|:.|    :||...
Zfish   621 MLIAMISNSFQRIEDDADVEWKFARSKLYLSYFREGLTMPVPFNIIPSPKAFFYILRGIFQKICC 685

  Fly   712 --GRKRP------SRTKSFMRKSMERAQ---TLHDKVMKLLVRRYITAEQRRRDDYGITEDDIIE 765
              .:|.|      |.:.:.|.....:.:   ....:|.|.||.|||.|.:|..::         .
Zfish   686 CCQKKAPEYPPITSVSSNAMNSGGGQGEGRVPYRLQVTKALVHRYIEAARREFEE---------S 741

  Fly   766 VRQDISSLRFELLEIFTNNNWDVPDIEKKSQGVARTTKGKVMERRILKDFQIGFVENLKQ-EMSE 829
            .|:|:.:...||.::....:.::.|.::|   :....||:..:..||..:..|...|.:. :.:|
Zfish   742 TRKDVGNRITELNKVVGRLHTEMKDFQQK---LKWQNKGEPDQANILGKYIKGAKNNFRDFDKNE 803

  Fly   830 SESGRDI---FSSLAKVIGRKKTQKGDKD 855
            :....::   ||:..:    ::..|.|:|
Zfish   804 AMGCENVGLRFSTHPE----EEKSKADED 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trp	NP_476768.1	trp	16..776	CDD:273311	239/789 (30%)
		ANK	64..>168	CDD:238125	32/112 (29%)
		ANK repeat	69..98	CDD:293786	8/32 (25%)
		ANK repeat	99..135	CDD:293786	9/38 (24%)
		ANK repeat	137..168	CDD:293786	13/32 (41%)
		TRP_2	178..236	CDD:285535	23/57 (40%)
		BASP1	938..1158	CDD:283191
trpc2a	XP_017206723.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000660
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910