DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trp and zgc:110224

DIOPT Version :9

Sequence 1:	NP_476768.1	Gene:	trp / 43542	FlyBaseID:	FBgn0003861	Length:	1275	Species:	Drosophila melanogaster
Sequence 2:	NP_001017642.1	Gene:	zgc:110224 / 550335	ZFINID:	ZDB-GENE-050417-120	Length:	403	Species:	Danio rerio

Alignment Length:	349	Identity:	64/349 - (18%)
Similarity:	114/349 - (32%)	Gaps:	79/349 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   797 GVARTTKGKVMERRILKDFQIGFVE--NLKQEMSESESGRDIFSSLAKVIGRKKTQKGDKDWNAI 859
            ||.|      :|.::.|...|||::  |......:.:.||..:||             |..:..:
Zfish    43 GVLR------VELQMEKVSAIGFIDVGNYGSAFIQVDVGRSSWSS-------------DHPFVTL 88

  Fly   860 ARKNTFASDPIGSK----RSSMQRHSQRSLRRKIIEQANEGLQMNQTQLIEFNPNLGDVTRATRV 920
            ....|..| |..||    |.:::...:.....:..|::.:.:::..||....:...|
Zfish    89 LPTATLMS-PADSKQGTGRQNVRMFKKADFLSRAAEESWDRMRVTCTQPFNKHTQFG-------- 144

  Fly   921 AYVKFMRKKMAADEVSLADDEGAPNGEGEKKPLDASGSKKSITSGG---------TGGGAS---- 972
              :.|:|.:...|:...:.::.....|..:.|...|...:.::|..         ||.|:|
Zfish   145 --LSFLRIRTVEDDTEDSSEQQEDTPENLRTPEKMSSVMEWLSSPAVQNTFFGRITGDGSSEAQR 207

  Fly   973 ---MLAAAALRASVKNVDEKSGADGKPGTMGKPTDDKKAGDDKDKQQPPKDSKPSAGGPKPGDQK 1034
               .|:.|........:..:|.:.....|....|..:   :|..|       .|..|....|:..
Zfish   208 NAGSLSRAERMVKAAQLKRRSLSTSPCSTASSTTPQR---EDNSK-------SPPGGFTTSGELV 262

  Fly  1035 PTPGAGAPKPQAAGTISKPGESQKKDAPAPPTKPGDTKPAAPKPGESAKPEAAAKKEESSKTEA- 1098
            .||.....||:|...:.......|:..|...|....|.|..|:                |:.||
Zfish   263 KTPQEQRRKPKARQILLNSDTPLKRSRPTGSTHDHPTSPKLPR----------------SQAEAR 311

  Fly  1099 SKPAATNGAAKSAAPSAPSDAKPD 1122
            .||.....:.:::.|.......||
Zfish   312 QKPIDAQDSPETSCPLCGESFSPD 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trp	NP_476768.1	trp	16..776	CDD:273311
		ANK	64..>168	CDD:238125
		ANK repeat	69..98	CDD:293786
		ANK repeat	99..135	CDD:293786
		ANK repeat	137..168	CDD:293786
		TRP_2	178..236	CDD:285535
		BASP1	938..1158	CDD:283191	37/202 (18%)
zgc:110224	NP_001017642.1	XRCC1_N	1..149	CDD:280080	25/135 (19%)
zgc:110224	NP_001017642.1	zf-C2HC_2	369..391	CDD:290624
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3609
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900