DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trp and trpl

DIOPT Version :9

Sequence 1:	NP_476768.1	Gene:	trp / 43542	FlyBaseID:	FBgn0003861	Length:	1275	Species:	Drosophila melanogaster
Sequence 2:	NP_476895.1	Gene:	trpl / 36003	FlyBaseID:	FBgn0005614	Length:	1124	Species:	Drosophila melanogaster

Alignment Length:	1228	Identity:	494/1228 - (40%)
Similarity:	697/1228 - (56%)	Gaps:	193/1228 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GSNTESDAEKALGSRLDYDLMMAEEYILSDVEKNFILSCERGDLPGVKKILEEYQGTDKFNINCT 66
            |.:..|.|.|::|. ....|.:.:..:|.  ||.|:|:.||||:|.|::||::.......||||.
  Fly    14 GVSHASSAPKSVGG-CCVPLGLPQPLLLE--EKKFLLAVERGDMPNVRRILQKALRHQHININCM 75

  Fly    67 DPMNRSALISAIENENFDLMVILLEHNIEVGDALLHAISEEYVEAVEELLQWEETNHKEGQPYSW 131
            ||:.|.||..||:|||.:::.:|:...:|..|||||||:.|:|||||.||:.||..:|||:||||
  Fly    76 DPLGRRALTLAIDNENLEMVELLVVMGVETKDALLHAINAEFVEAVELLLEHEELIYKEGEPYSW 140

  Fly   132 EAVDRSKSTFTVDITPLILAAHRNNYEILKILLDRGATLPMPHDVKCGCDECVTSQMTDSLRHSQ 196
            :.||.:.:.|..|||||:||||:||:|||:|||||||.:|:|||::|||:|||.....||||||.
  Fly   141 QKVDINTAMFAPDITPLMLAAHKNNFEILRILLDRGAAVPVPHDIRCGCEECVRLTAEDSLRHSL 205

  Fly   197 SRINAYRALSASSLIALSSRDPVLTAFQLSWELKRLQAMESEFRAEYTEMRQMVQDFGTSLLDHA 261
            ||:|.||||.:.|||.|:|.||::|||||||||:.|...|.|.::||.::|:..|.|...|||..
  Fly   206 SRVNIYRALCSPSLICLTSNDPIITAFQLSWELRNLALTEQECKSEYMDLRRQCQKFAVDLLDQT 270

  Fly   262 RTSMELEVMLNF-----NHEPSHDIWCLGQRQTLERLKLAIRYKQKTFVAHPNVQQLLAAIWYDG 321
            |||.||.::||:     ::||       |.|.:|.||..||.||||.||||.|:||||::|||||
  Fly   271 RTSNELAIILNYDPQMSSYEP-------GDRMSLTRLVQAISYKQKKFVAHSNIQQLLSSIWYDG 328

  Fly   322 LPGFRRKQASQQLMDVVKLGCSFPIYSLKYILAPDSEGAKFMRKPFVKFITHSCSYMFFLMLLGA 386
            |||||||....:::.:.::...||:|.|.|:.||:....:.|||||:||:.|:.||:|||.:|..
  Fly   329 LPGFRRKSIVDKVICIAQVAVLFPLYCLIYMCAPNCRTGQLMRKPFMKFLIHASSYLFFLFILIL 393

  Fly   387 ASLRVVQITFELLAFPWMLTMLEDWRKHERGSLPGPIELAIITYIMALIFEELKSLYSDGLFEYI 451
            .|.|.......:.....|...|.:....:||..|..:||.::.|::..::||::.:::.|:..|:
  Fly   394 VSQRADDDFVRIFGTTRMKKELAEQELRQRGQTPSKLELIVVMYVIGFVWEEVQEIFAVGMKSYL 458

  Fly   452 MDLWNIVDYISNMFYVTWILCRATAWVIVHRDLWFRGIDP---YFPREHWHPFDPMLLSEGAFAA 513
            .::||.:|::.|..||:.:..||.|::....::   ..||   |.|||.||.|||.|::||.|||
  Fly   459 RNMWNFIDFLRNSLYVSVMCLRAFAYIQQATEI---ARDPQMAYIPREKWHDFDPQLIAEGLFAA 520

  Fly   514 GMVFSYLKLVHIFSINPHLGPLQVSLGRMIIDIIKFFFIYTLVLFAFGCGLNQLLWYYAELEKNK 578
            ..|||.|||||:|||||||||||:|||||:|||:|||||||||||||.|||||||||:|.|||:|
  Fly   521 ANVFSALKLVHLFSINPHLGPLQISLGRMVIDIVKFFFIYTLVLFAFACGLNQLLWYFAALEKSK 585

  Fly   579 CYHLHPDVADFDDQEKACTIWRRFSNLFETSQSLFWASFGLVDLVSFDLAGIKSFTRFWALLMFG 643
            ||.|....||:.....:|..||||.||||:||||||||||:|.|..|:|:||||:||||.|||||
  Fly   586 CYVLPGGEADWGSHGDSCMKWRRFGNLFESSQSLFWASFGMVGLDDFELSGIKSYTRFWGLLMFG 650

  Fly   644 SYSVINIIVLLNMLIAMMSNSYQIISERADTEWKFARSQLWMSYFEDGGTIPPPFNLCPNMKML- 707
            ||||||:|||||:|||||||||.:|.|.:||||||||::||||||||..|:|||||:.|::|.:
  Fly   651 SYSVINVIVLLNLLIAMMSNSYAMIDEHSDTEWKFARTKLWMSYFEDSATLPPPFNVLPSVKWVI 715

  Fly   708 ------RKTLGRKRPSRTKSFMRKSMERAQTLHDKVMKLLVRRYITAEQRRRDDYGITEDDIIEV 766
                  .||:.|:|..:     ||..|:... :|.:|:.||.||:.|..|:.::..::||||.||
  Fly   716 RIFRKSSKTIDRQRSKK-----RKEQEQFSE-YDNIMRSLVWRYVAAMHRKFENNPVSEDDINEV 774

  Fly   767 RQDISSLRFELLEIFTNNNWDVPDIEKKSQGVARTTKGKVMERRILKDFQIGFVE---------- 821
            :.:|:::|:|:||||.|:..||....||.: ..|..:.||.|||::|.||:..|:
  Fly   775 KSEINTMRYEMLEIFENSGMDVSSANKKER-QPRPRRIKVWERRLMKGFQVAPVQNGCELDAFGN 838

  Fly   822 -NLKQEMSE-----------SESGRDIFSSLAK-VIGRKKTQKGDKDWNAIARKNTFASDPIGSK 873
             |.:.||.|           .|:.::.|..:|: |:.:..|.|    ||.:.|.   |.|....:
  Fly   839 VNGQGEMQEIKVESIPSKPAKETAKERFQRVARTVLLQSTTHK----WNVVLRA---AKDSQIGR 896

  Fly   874 RSSMQRHSQRSLRRKIIEQANEGLQMNQTQLIEFNPNLGDVTRATRVAYVKFMRKKMAADEVSLA 938
            .:..:|.|.::|.| .||:|.        :||..||
  Fly   897 CTKNERKSLQNLGR-AIEEAK--------RLIMLNP----------------------------- 923

  Fly   939 DDEGAPNGEGEKKPLDASGSKKSITSGGTGGGASMLAAA-ALRASVKNVDE-KSGADGKPGTMGK 1001
               |.|:|......::....|.|          ::|... .:.|.:.:.:: |.....:|.....
  Fly   924 ---GCPSGRESPIRIEFEDEKTS----------TLLELLNQISAEISDSEKPKIRPIWRPPLKTV 975

  Fly  1002 PTDDKKAGDDKDKQQPP-KDSKPSAGGPKPGDQKPTPGAGAPKPQAAGTISKPGESQ--KKDAPA 1063
            |.....|.:.:....|. |.|:.|:..|.|   .||||           :|....||  .::.|.
  Fly   976 PARAMAANNTRSLTAPELKISRKSSPAPTP---TPTPG-----------VSHTALSQFRNRELPL 1026

  Fly  1064 PPTK-PGDTKPAAPKPGESAKPEAAAKKEESSKTEASKPAATNGAAKSAAPSAPSDAKPDSKLKP 1127
            .|:| ..::.|:||    :|.|                        |.:||:||:.....:...|
  Fly  1027 CPSKLIANSAPSAP----TAPP------------------------KKSAPTAPTPTYKPTTHAP 1063

  Fly  1128 GA--AGAPEATKATNGASKP-----------DEK----------------KSGPEEPK 1156
            .:  .|..|.|:|::|....           |||                .:.|:.||
  Fly  1064 FSVEGGNRENTRASDGVRSDNSNFDIHVVDLDEKGGHLGRDNVSDISSIASTSPQRPK 1121

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trp	NP_476768.1	trp	16..776	CDD:273311	394/774 (51%)
		ANK	64..>168	CDD:238125	60/103 (58%)
		ANK repeat	69..98	CDD:293786	10/28 (36%)
		ANK repeat	99..135	CDD:293786	23/35 (66%)
		ANK repeat	137..168	CDD:293786	20/30 (67%)
		TRP_2	178..236	CDD:285535	36/57 (63%)
		BASP1	938..1158	CDD:283191	49/254 (19%)
trpl	NP_476895.1	trp	48..784	CDD:273311	388/751 (52%)
		ANK	48..195	CDD:238125	82/146 (56%)
		ANK repeat	78..114	CDD:293786	16/35 (46%)
		ANK repeat	134..177	CDD:293786	28/42 (67%)
		TRP_2	187..246	CDD:285535	36/58 (62%)
		DUF2031	<706..>805	CDD:299055	36/105 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450243
Domainoid	1	1.000	270	1.000	Domainoid score	I1782
eggNOG	1	0.900	-	-		E1_KOG3609
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	774	1.000	Inparanoid score	I517
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D824310at2759
OrthoFinder	1	1.000	-	-		FOG0000660
OrthoInspector	1	1.000	-	-		mtm6331
orthoMCL	1	0.900	-	-		OOG6_102173
Panther	1	1.100	-	-	P	PTHR10117
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X802
	11	10.800