DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trp and Trpc6

DIOPT Version :9

Sequence 1:	NP_476768.1	Gene:	trp / 43542	FlyBaseID:	FBgn0003861	Length:	1275	Species:	Drosophila melanogaster
Sequence 2:	XP_006509912.1	Gene:	Trpc6 / 22068	MGIID:	109523	Length:	949	Species:	Mus musculus

Alignment Length:	903	Identity:	299/903 - (33%)
Similarity:	451/903 - (49%)	Gaps:	188/903 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LSDVEKNFILSCERGDLPGVKKILEEYQGTDKFNINCTDPMNRSALISAIENENFDLMVILL--E 91
            ||..|:.|:.:.|.|::|.|:|:|||   ....|:||.|.|.::||..|:.||:.::..:||  |
Mouse   113 LSIEEERFLDAAEYGNIPVVRKMLEE---CHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKE 174

  Fly    92 HNIEVGDALLHAISEEYVEAVEELLQWEETNH---------------KEGQPYSWEAVDRSKSTF 141
            :...||||||.|||:.||..||.:|     ||               .|.|...:.|.|...:.|
Mouse   175 NLSRVGDALLLAISKGYVRIVEAIL-----NHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRF 234

  Fly   142 TVDITPLILAAHRNNYEILKILLDRGATLPMPHDVKCGCDECVTSQMTDSLRHSQSRINAYRALS 206
            :.|:||:|||||...|||:..||.:||.:..|||..|.|.||...|..||..||:||||||:.|:
Mouse   235 SHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCTECSQKQKHDSFSHSRSRINAYKGLA 299

  Fly   207 ASSLIALSSRDPVLTAFQLSWELKRLQAMESEFRAEYTEMRQMVQDFGTSLLDHARTSMELEVML 271
            :.:.::|||.|||:||.:||.||..|..:|.||:.:|.::....:||...|||..|.:.|:|.:|
Mouse   300 SPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYRKLSMQCKDFVVGLLDLCRNTEEVEAIL 364

  Fly   272 NFNHEPSHDIWCLGQ--RQTLERLKLAIRYKQKTFVAHPNVQQLLAAIWYDGLPGFRRKQASQQL 334
            |.:.|....    |.  |..|.||||||:|:.|.||||||.||.|.:|||:.|.|.|::..:.:.
Mouse   365 NGDAETRQP----GDFGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKF 425

  Fly   335 MDVVKLGCSFPIYSLKYILAPDSEGAKFMRKPFVKFITHSCSYMFF--LMLLGAASLRVVQITFE 397
            :.|:.:....|..:|.|..||.|:..|.:|.||:||:.|:.|:..|  |:::.||.      .||
Mouse   426 LVVLAVAIGLPFLALIYWCAPCSKMGKILRGPFMKFVAHAASFTIFLGLLVMNAAD------RFE 484

  Fly   398 ---LL------------------AFPWMLTMLEDWRKHERGSLPGPIELAIITYIMALIFEELKS 441
               ||                  .|.||                   |:.||::::.:|:.|.|.
Mouse   485 GTKLLPNETSTDNARQLFRMKTSCFSWM-------------------EMLIISWVIGMIWAECKE 530

  Fly   442 LYSDGLFEYIMDLWNIVDYISNMFYVTWILCRATAWVIVHRDLWFRG-----ID----------- 490
            :::.|..||:.:|||::|:.....:....:.|..|:       |...     ||
Mouse   531 IWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAF-------WHASKAQSIIDANDTLKDLTKV 588

  Fly   491 ------PYF--PREHWHPFDPMLLSEGAFAAGMVFSYLKLVHIFSINPHLGPLQVSLGRMIIDII 547
                  .|:  .|..|.|.||.::|||.:|..:|.|:.::.:|...|...||||:||||.:.||.
Mouse   589 TLGDNVKYYNLARIKWDPTDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIF 653

  Fly   548 KFFFIYTLVLFAFGCGLNQLLWYYAELEKNKCYHLHPDVADFDDQEKACTIWRRFSNLFETSQSL 612
            ||..|:.:|..||..|:..|..||...::|:.                      |:.:.|:.::|
Mouse   654 KFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEA----------------------FTTVEESFKTL 696

  Fly   613 FWASFGLVDLVSFDLAGIKSFTRFWALLMFGSYSVINIIVLLNMLIAMMSNSYQIISERADTEWK 677
            |||.|||.::.|..:.....|......:::|.|:|..:||||||||||:::|:|.|.:.||.|||
Mouse   697 FWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWK 761

  Fly   678 FARSQLWMSYFEDGGTIPPPFNLCPNMKMLRKTL------------GRKRPSRTKSFMRK----- 725
            |||::||.||||:|.|:|.||||.|:.|.|...|            |:|:..:..:.|.|
Mouse   762 FARAKLWFSYFEEGRTLPVPFNLVPSPKSLLYLLLKFKKWMCELIQGQKQGFQEDAEMNKRNEEK 826

  Fly   726 --------------SMERAQTLHD------------------------KVMKLLVRRYITAEQRR 752
                          |:::.|..|:                        |:||.|::||:...|..
Mouse   827 KFGISGSHEDLSKFSLDKNQLAHNKQSSTRSSEDYHLNSFSNPPRQYQKIMKRLIKRYVLQAQID 891

  Fly   753 RDDYGITEDDIIEVRQDISSLRFELLEIFTNNNWDVPDIEKKSQGVARTTKGKVMERR 810
            ::...:.|.::.|::|||||||:||||..:.|..|:.::.:| .|...:.:.|:.|.|
Mouse   892 KESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIRK-LGERLSLEPKLEESR 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trp	NP_476768.1	trp	16..776	CDD:273311	288/867 (33%)
		ANK	64..>168	CDD:238125	46/120 (38%)
		ANK repeat	69..98	CDD:293786	10/30 (33%)
		ANK repeat	99..135	CDD:293786	16/50 (32%)
		ANK repeat	137..168	CDD:293786	14/30 (47%)
		TRP_2	178..236	CDD:285535	29/57 (51%)
		BASP1	938..1158	CDD:283191
Trpc6	XP_006509912.1	trp	100..915	CDD:273311	288/867 (33%)
		ANK repeat	150..177	CDD:293786	9/26 (35%)
		ANK repeat	179..203	CDD:293786	16/28 (57%)
		ANK repeat	230..265	CDD:293786	16/34 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3609
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.770