Protein Alignment trp and Trpc5

DIOPT Version :10

• Sequence 1: NP_476768.1
• Gene: trp / 43542
• FlyBaseID: FBgn0003861
• Length: 1275
• Species: Drosophila melanogaster
• Sequence 2: NP_033454.1
• Gene: Trpc5 / 22067
• MGIID: 109524
• Length: 975
• Species: Mus musculus
• Alignment Length: 1061
• Identity: 395/1061 - (37%)
• Similarity: 567/1061 - (53%)
• Gaps: 168/1061 - (15%)

  Fly    16 RLDYDLMMAEEYILSDVEKNFILSCERGDLPGVKKILEEYQGTDKFNINCTDPMNRSALISAIEN 80
            |:...::.||.. ||..||.|:.:.|:||...||:.|:|.:.....||||.||:.||||:.||||
Mouse    17 RIPLQIVRAETE-LSAEEKAFLSAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIEN 80

  Fly    81 ENFDLMVILLEHNIEVGDALLHAISEEYVEAVEELLQWEETNHKEGQPYSWEAVDRSKSTFTVDI 145
            ||.::|.:||.|::.||||||:||.:|.|.|||.||.:.:.:.::..|..  .:|...|.||.||
Mouse    81 ENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRKPSGEKQVPTL--MMDTQFSEFTPDI 143

  Fly   146 TPLILAAHRNNYEILKILLDRGATLPMPHDVKCGCDECVTSQMTDSLRHSQSRINAYRALSASSL 210
            ||::||||.|||||:|:|:.:..|:|.||.::|.|.|||:|...||||||:||:|.|:||::.||
Mouse   144 TPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSL 208

  Fly   211 IALSSRDPVLTAFQLSWELKRLQAMESEFRAEYTEMRQMVQDFGTSLLDHARTSMELEVMLNFNH 275
            |||||.||:||||:|.||||.|..:|:||:|||.|:.|..:.|...|||.||:|.|||::||...
Mouse   209 IALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRD 273

  Fly   276 EPS--------HDIWCLGQRQTLERLKLAIRYKQKTFVAHPNVQQLLAAIWYDGLPGFRRKQASQ 332
            :.|        ||         |.:||:||:|.||.|||.||.|||||.:||||.||:|||....
Mouse   274 DHSEELDPQKYHD---------LAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVV 329

  Fly   333 QLMDVVKLGCSFPIYSLKYILAPDSEGAKFMRKPFVKFITHSCSYMFFLMLLGAASLRVVQITFE 397
            :|:..:.:|..||:.|:.|:::|.|....|::|||:|||.|:.||:.||.:|..||..:|:...
Mouse   330 KLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDL- 393

  Fly   398 LLAFPWMLTMLEDWRKHERGSLPGPIELAIITYIMALIFEELKSLYSDGLFEYIMDLWNIVDYIS 462
                            |.:|..|..:|..|:.:::..|:.|:|.::..|..|||.|.||::|:..
Mouse   394 ----------------HVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAM 442

  Fly   463 NMFYVTWILCRATAWVIVHRDLWFRGIDPYFPREHWHPFDPMLLSEGAFAAGMVFSYLKLVHIFS 527
            |..|:..|..:..|:|..:...         |||.|..:.|.|::|..||...:.|.|:|:.:|:
Mouse   443 NSLYLATISLKIVAYVKYNGSR---------PREEWEMWHPTLIAEALFAISNILSSLRLISLFT 498

  Fly   528 INPHLGPLQVSLGRMIIDIIKFFFIYTLVLFAFGCGLNQLLWYY---AELEKNKCYHLHPDVADF 589
            .|.||||||:|||||::||:||.|||.|||.||..|||||.:||   |..|.|.|..:.     .
Mouse   499 ANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIR-----C 558

  Fly   590 DDQEKACTIWRRFSNLFETSQSLFWASFGLVDLVSFDLAGIKSFTRFWALLMFGSYSVINIIVLL 654
            :.|..|      ||.||||.|||||:.|||::|...::.....||.|....|||:|:||:::|||
Mouse   559 EKQNNA------FSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLL 617

  Fly   655 NMLIAMMSNSYQIISERADTEWKFARSQLWMSYFEDGGTIPPPFNLCPNMKML------------ 707
            |||||||:||||:|::.||.||||||::||||||::|||:|||||:.|:.|..
Mouse   618 NMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFC 682

  Fly   708 --RKTLGRKRPSRTKSFMRKSMER-AQTLH-DKVMKLLVRRYITAEQRR-RDDYGITEDDIIEVR 767
              |...||:|....:||..:..:. .|..| .:|::.||:||:.|..|. :.:.|:||::..|::
Mouse   683 PKRDPDGRRRRHNLRSFTERHADSLIQNQHYQEVIRNLVKRYVAAMIRNSKTNEGLTEENFKELK 747

  Fly   768 QDISSLRFELLEIFTNN------------NWDVPDIEKKSQGVARTTKGKVMERRILKDFQIGFV 820
            |||||.|:|:|::..|.            ::...|......|.||.....|       .|.:|..
Mouse   748 QDISSFRYEVLDLLGNRKHPRRSLSTSSADFSQRDDTNDGSGGARAKSKSV-------SFNVGCK 805

  Fly   821 ENL-----------------KQEMSESESGRDIFSSLAKVIGRKKTQKGDKDWNAIARKNTFASD 868
            :..                 .:..|||.|.|.......|.:|...::...:.....:......||
Mouse   806 KKACHGAPLIRTVPRASGAQGKPKSESSSKRSFMGPSFKKLGLFFSKFNGQTSEPTSEPMYTISD 870

  Fly   869 PIGSKRSSMQ--RHSQRSLRRKIIEQANEGLQMNQTQLIEFNPNLGDVTRATRVAYVKFMRKKMA 931
            .|..:....|  |:||.        :..:....:|:|:     |||
Mouse   871 GIAQQHCMWQDIRYSQM--------EKGKAEACSQSQM-----NLG------------------- 903

  Fly   932 ADEVSLADDEGAPNGEGEKKPLDASGSKKSITSGGTGGGASMLAAAALRASVKNVDEKSGADGKP 996
              ||.|.:..||. ....:.|| |..|.....||.....:.:|      .|.::|.|
Mouse   904 --EVELGEIRGAA-ARSSECPL-ACSSSLHCASGICSSNSKLL------DSSEDVFE-------- 950

  Fly   997 GTMGKPTD--DKKAGDDKDKQ 1015
             |.|:..|  ..|.||.:::|
Mouse   951 -TWGEACDLLMHKWGDGQEEQ 970

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trp	NP_476768.1	trp	16..776	CDD:273311	344/787 (44%)
		ANK repeat	69..98	CDD:293786	15/28 (54%)
		ANK repeat	99..135	CDD:293786	13/35 (37%)
		ANK repeat	137..168	CDD:293786	18/30 (60%)
		TRP_CaM_bind1	797..860	CDD:467881	13/79 (16%)
		PRK12323	<891..1102	CDD:481241	27/127 (21%)
		PspC_subgroup_2	<1015..1156	CDD:468202	1/1 (100%)
Trpc5	NP_033454.1	trp	17..756	CDD:273311	344/787 (44%)
		ANK 1. /evidence=ECO:0000250|UniProtKB:Q9UL62	30..60		11/29 (38%)
		ANK repeat	69..98	CDD:293786	15/28 (54%)
		ANK 2. /evidence=ECO:0000250|UniProtKB:Q9UL62	69..97		14/27 (52%)
		ANK 3. /evidence=ECO:0000250|UniProtKB:Q9UL62	98..124		13/25 (52%)
		ANK 4. /evidence=ECO:0000250|UniProtKB:Q9UL62	141..170		16/28 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	766..795		4/28 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	816..838		5/21 (24%)
		Essential for binding to NHERF1 PDZ domain. /evidence=ECO:0000269|PubMed:10980202	971..973		395/1061 (37%)