Protein Alignment trp and Trpc4

DIOPT Version :10

• Sequence 1: NP_476768.1
• Gene: trp / 43542
• FlyBaseID: FBgn0003861
• Length: 1275
• Species: Drosophila melanogaster
• Sequence 2: NP_058680.1
• Gene: Trpc4 / 22066
• MGIID: 109525
• Length: 974
• Species: Mus musculus
• Alignment Length: 921
• Identity: 376/921 - (40%)
• Similarity: 559/921 - (60%)
• Gaps: 94/921 - (10%)

  Fly    16 RLDYDLMMAEEYILSDVEKNFILSCERGDLPGVKKILEEYQGTDKFNINCTDPMNRSALISAIEN 80
            |:...::.||.. ||..||.::.:.|:||...|||.|||.:...|.||||.||:.|:||:.||||
Mouse    17 RIPLRIVRAESE-LSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIEN 80

  Fly    81 ENFDLMVILLEHNIEVGDALLHAISEEYVEAVEELLQWEETNHKEGQPYSWEAV-----DRSKST 140
            ||.:|:.:||..|:.|||||||||.:|.|.|||.||     |||  :|...:.|     |:..|.
Mouse    81 ENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLL-----NHK--KPSGEKQVPPILLDKQFSE 138

  Fly   141 FTVDITPLILAAHRNNYEILKILLDRGATLPMPHDVKCGCDECVTSQMTDSLRHSQSRINAYRAL 205
            ||.||||:|||||.|||||:|:|:.:|.::|.||:|:|.|.|||:|...||||||:||:|.|:||
Mouse   139 FTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKAL 203

  Fly   206 SASSLIALSSRDPVLTAFQLSWELKRLQAMESEFRAEYTEMRQMVQDFGTSLLDHARTSMELEVM 270
            ::.|||||||.||.||||||||||:.|..:|:||::||.|:.:..:.|...|||..|:|.|||::
Mouse   204 ASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEII 268

  Fly   271 LNFNHEPSHDIWCLGQRQT---LERLKLAIRYKQKTFVAHPNVQQLLAAIWYDGLPGFRRKQASQ 332
            ||:..:.|     |.:.|:   |.||||||:|:||.|||.||.|||||:.|||..||:||:..:.
Mouse   269 LNYRDDNS-----LIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAV 328

  Fly   333 QLMDVVKLGCSFPIYSLKYILAPDSEGAKFMRKPFVKFITHSCSYMFFLMLLGAASLRVVQITFE 397
            :::....:|..||::|:.|::||.|....|:||||:|||.|:.||:.||.||..||..:.:...
Mouse   329 KMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDL- 392

  Fly   398 LLAFPWMLTMLEDWRKHERGSLPGPIELAIITYIMALIFEELKSLYSDGLFEYIMDLWNIVDYIS 462
                            :.:|..|..:|..|:.:::..|:.|:|.::..||.:||.|.||::|::.
Mouse   393 ----------------NRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVM 441

  Fly   463 NMFYVTWILCRATAWVIVHRDLWFRGIDPYFPREHWHPFDPMLLSEGAFAAGMVFSYLKLVHIFS 527
            |..|:..|..:..|:|      .:..::   |||.|..:.|.|::|..||...:||.|:|:.:|:
Mouse   442 NSLYLATISLKIVAFV------KYSALN---PRESWDMWHPTLVAEALFAIANIFSSLRLISLFT 497

  Fly   528 INPHLGPLQVSLGRMIIDIIKFFFIYTLVLFAFGCGLNQLLWYYAELEKNKCYHLHPDVADFDDQ 592
            .|.||||||:|||||::||:||.|||.|||.||..|||||.:||.|.:...|..:.     .:.|
Mouse   498 ANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLSCKGIR-----CEKQ 557

  Fly   593 EKACTIWRRFSNLFETSQSLFWASFGLVDLVSFDLAGIKSFTRFWALLMFGSYSVINIIVLLNML 657
            ..|      ||.||||.|||||:.|||::|...::.....||.|....|||:|:||:::||||||
Mouse   558 NNA------FSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNML 616

  Fly   658 IAMMSNSYQIISERADTEWKFARSQLWMSYFEDGGTIPPPFNLCPNMKML------------RKT 710
            ||||:||||:|::.||.||||||::|||||||:|||:|.|||:.|:.|.|            :|.
Mouse   617 IAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLVKWIWTHLCKKK 681

  Fly   711 LGRKRPSRTKSFMRKSMERAQTLH--DKVMKLLVRRYITAEQRR-RDDYGITEDDIIEVRQDISS 772
            : |::|....:..|::.:..:..|  .:||:.||:||:.|..|. :.:.|:||:::.|::|||||
Mouse   682 M-RRKPESFGTIGRRAADNLRRHHQYQEVMRNLVKRYVAAMIREAKTEEGLTEENVKELKQDISS 745

  Fly   773 LRFELL---------EIFTNNNWDVPDIEKKSQGVARTTKGKVMERRILKDFQIGFVENLKQEMS 828
            .|||:|         .|.:.|.....|.::|||     ::|...::|  |:..:..:..|....|
Mouse   746 FRFEVLGLLRGSKLSTIQSANAASSADSDEKSQ-----SEGNGKDKR--KNLSLFDLTTLIHPRS 803

  Fly   829 ES-ESGRDIFSSLAKVIGRKKTQKGDKDWNAIARKNTFASDPIGSKRSSMQRHSQR--SLRRKII 890
            .: .|.|...|:.:.::.::..::..:..|.:|....|......||:::.::::.:  |:..:|.
Mouse   804 AAIASERHNLSNGSALVVQEPPREKQRKVNFVADIKNFGLFHRRSKQNAAEQNANQIFSVSEEIT 868

  Fly   891 -EQANEGLQMN 900
             :||...|:.|
Mouse   869 RQQAAGALERN 879

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trp	NP_476768.1	trp	16..776	CDD:273311	348/782 (45%)
		ANK repeat	69..98	CDD:293786	14/28 (50%)
		ANK repeat	99..135	CDD:293786	18/40 (45%)
		ANK repeat	137..168	CDD:293786	19/30 (63%)
		TRP_CaM_bind1	797..860	CDD:467881	9/63 (14%)
		PRK12323	<891..1102	CDD:481241	4/10 (40%)
		PspC_subgroup_2	<1015..1156	CDD:468202
Trpc4	NP_058680.1	trp	17..749	CDD:273311	348/782 (45%)
		ANK 1. /evidence=ECO:0000250|UniProtKB:Q9UBN4	29..60		13/30 (43%)
		ANK 2. /evidence=ECO:0000250|UniProtKB:Q9UBN4	71..93		12/21 (57%)
		Multimerization domain. /evidence=ECO:0000269|PubMed:19070363	87..172		46/91 (51%)
		ANK repeat	122..167	CDD:293786	22/44 (50%)
		Multimerization domain. /evidence=ECO:0000269|PubMed:19070363	254..304		26/54 (48%)
		Interaction with ITPR1, ITPR2 and ITPR3. /evidence=ECO:0000250|UniProtKB:Q9UBN4	615..974		87/273 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	765..787		6/26 (23%)
		PDZ-binding domain. /evidence=ECO:0000250|UniProtKB:Q9UBN4	972..974