DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trp and Trpc4

DIOPT Version :9

Sequence 1:	NP_476768.1	Gene:	trp / 43542	FlyBaseID:	FBgn0003861	Length:	1275	Species:	Drosophila melanogaster
Sequence 2:	NP_058680.1	Gene:	Trpc4 / 22066	MGIID:	109525	Length:	974	Species:	Mus musculus

Alignment Length:	921	Identity:	376/921 - (40%)
Similarity:	559/921 - (60%)	Gaps:	94/921 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RLDYDLMMAEEYILSDVEKNFILSCERGDLPGVKKILEEYQGTDKFNINCTDPMNRSALISAIEN 80
            |:...::.||.. ||..||.::.:.|:||...|||.|||.:...|.||||.||:.|:||:.||||
Mouse    17 RIPLRIVRAESE-LSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININCIDPLGRTALLIAIEN 80

  Fly    81 ENFDLMVILLEHNIEVGDALLHAISEEYVEAVEELLQWEETNHKEGQPYSWEAV-----DRSKST 140
            ||.:|:.:||..|:.|||||||||.:|.|.|||.||     |||  :|...:.|     |:..|.
Mouse    81 ENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLL-----NHK--KPSGEKQVPPILLDKQFSE 138

  Fly   141 FTVDITPLILAAHRNNYEILKILLDRGATLPMPHDVKCGCDECVTSQMTDSLRHSQSRINAYRAL 205
            ||.||||:|||||.|||||:|:|:.:|.::|.||:|:|.|.|||:|...||||||:||:|.|:||
Mouse   139 FTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKAL 203

  Fly   206 SASSLIALSSRDPVLTAFQLSWELKRLQAMESEFRAEYTEMRQMVQDFGTSLLDHARTSMELEVM 270
            ::.|||||||.||.||||||||||:.|..:|:||::||.|:.:..:.|...|||..|:|.|||::
Mouse   204 ASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEII 268

  Fly   271 LNFNHEPSHDIWCLGQRQT---LERLKLAIRYKQKTFVAHPNVQQLLAAIWYDGLPGFRRKQASQ 332
            ||:..:.|     |.:.|:   |.||||||:|:||.|||.||.|||||:.|||..||:||:..:.
Mouse   269 LNYRDDNS-----LIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAV 328

  Fly   333 QLMDVVKLGCSFPIYSLKYILAPDSEGAKFMRKPFVKFITHSCSYMFFLMLLGAASLRVVQITFE 397
            :::....:|..||::|:.|::||.|....|:||||:|||.|:.||:.||.||..||..:.:...
Mouse   329 KMVTCFIIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDL- 392

  Fly   398 LLAFPWMLTMLEDWRKHERGSLPGPIELAIITYIMALIFEELKSLYSDGLFEYIMDLWNIVDYIS 462
                            :.:|..|..:|..|:.:::..|:.|:|.::..||.:||.|.||::|::.
Mouse   393 ----------------NRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVM 441

  Fly   463 NMFYVTWILCRATAWVIVHRDLWFRGIDPYFPREHWHPFDPMLLSEGAFAAGMVFSYLKLVHIFS 527
            |..|:..|..:..|:|      .:..::   |||.|..:.|.|::|..||...:||.|:|:.:|:
Mouse   442 NSLYLATISLKIVAFV------KYSALN---PRESWDMWHPTLVAEALFAIANIFSSLRLISLFT 497

  Fly   528 INPHLGPLQVSLGRMIIDIIKFFFIYTLVLFAFGCGLNQLLWYYAELEKNKCYHLHPDVADFDDQ 592
            .|.||||||:|||||::||:||.|||.|||.||..|||||.:||.|.:...|..:.     .:.|
Mouse   498 ANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLSCKGIR-----CEKQ 557

  Fly   593 EKACTIWRRFSNLFETSQSLFWASFGLVDLVSFDLAGIKSFTRFWALLMFGSYSVINIIVLLNML 657
            ..|      ||.||||.|||||:.|||::|...::.....||.|....|||:|:||:::||||||
Mouse   558 NNA------FSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNML 616

  Fly   658 IAMMSNSYQIISERADTEWKFARSQLWMSYFEDGGTIPPPFNLCPNMKML------------RKT 710
            ||||:||||:|::.||.||||||::|||||||:|||:|.|||:.|:.|.|            :|.
Mouse   617 IAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLVKWIWTHLCKKK 681

  Fly   711 LGRKRPSRTKSFMRKSMERAQTLH--DKVMKLLVRRYITAEQRR-RDDYGITEDDIIEVRQDISS 772
            : |::|....:..|::.:..:..|  .:||:.||:||:.|..|. :.:.|:||:::.|::|||||
Mouse   682 M-RRKPESFGTIGRRAADNLRRHHQYQEVMRNLVKRYVAAMIREAKTEEGLTEENVKELKQDISS 745

  Fly   773 LRFELL---------EIFTNNNWDVPDIEKKSQGVARTTKGKVMERRILKDFQIGFVENLKQEMS 828
            .|||:|         .|.:.|.....|.::|||     ::|...::|  |:..:..:..|....|
Mouse   746 FRFEVLGLLRGSKLSTIQSANAASSADSDEKSQ-----SEGNGKDKR--KNLSLFDLTTLIHPRS 803

  Fly   829 ES-ESGRDIFSSLAKVIGRKKTQKGDKDWNAIARKNTFASDPIGSKRSSMQRHSQR--SLRRKII 890
            .: .|.|...|:.:.::.::..::..:..|.:|....|......||:::.::::.:  |:..:|.
Mouse   804 AAIASERHNLSNGSALVVQEPPREKQRKVNFVADIKNFGLFHRRSKQNAAEQNANQIFSVSEEIT 868

  Fly   891 -EQANEGLQMN 900
             :||...|:.|
Mouse   869 RQQAAGALERN 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trp	NP_476768.1	trp	16..776	CDD:273311	348/782 (45%)
		ANK	64..>168	CDD:238125	58/108 (54%)
		ANK repeat	69..98	CDD:293786	14/28 (50%)
		ANK repeat	99..135	CDD:293786	18/40 (45%)
		ANK repeat	137..168	CDD:293786	19/30 (63%)
		TRP_2	178..236	CDD:285535	38/57 (67%)
		BASP1	938..1158	CDD:283191
Trpc4	NP_058680.1	trp	17..749	CDD:273311	348/782 (45%)
		ANK 1	31..60		11/28 (39%)
		ANK 2	69..97		13/27 (48%)
		Multimerization domain	87..172		46/91 (51%)
		ANK repeat	122..167	CDD:293786	22/44 (50%)
		Multimerization domain	254..304		26/54 (48%)
		Binds to ITPR1, ITPR2 and ITPR3. /evidence=ECO:0000250	615..974		87/273 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	765..787		6/26 (23%)
		PDZ-binding domain. /evidence=ECO:0000250	972..974
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838106
Domainoid	1	1.000	275	1.000	Domainoid score	I1739
eggNOG	1	0.900	-	-		E1_KOG3609
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000660
OrthoInspector	1	1.000	-	-		mtm8704
orthoMCL	1	0.900	-	-		OOG6_102173
Panther	1	1.100	-	-	O	PTHR10117
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X802
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.740