DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trp and Trpc3

DIOPT Version :9

Sequence 1:	NP_476768.1	Gene:	trp / 43542	FlyBaseID:	FBgn0003861	Length:	1275	Species:	Drosophila melanogaster
Sequence 2:	NP_062383.2	Gene:	Trpc3 / 22065	MGIID:	109526	Length:	910	Species:	Mus musculus

Alignment Length:	827	Identity:	282/827 - (34%)
Similarity:	447/827 - (54%)	Gaps:	118/827 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LSDVEKNFILSCERGDLPGVKKILEEYQGTDKFNINCTDPMNRSALISAIENENFDLMVILL--E 91
            |:..|:.|:.:.|.|::|.|:|:|||   :...|:||.|.|.::||..|:.||:.::..:||  |
Mouse    98 LTAEEERFLDAAEYGNIPVVRKMLEE---SRTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKE 159

  Fly    92 HNIEVGDALLHAISEEYVEAVEELLQWEETNH---------------KEGQPYSWEAVDRSKSTF 141
            :...:|||||.|||:.||..||.:|     .|               :|.:...:.|.|...:.|
Mouse   160 NLARIGDALLLAISKGYVRIVEAIL-----GHPGFAASRRLTLSPCEQELRDDDFYAYDEDGTRF 219

  Fly   142 TVDITPLILAAHRNNYEILKILLDRGATLPMPHDVKCGCDECVTSQMTDSLRHSQSRINAYRALS 206
            :.||||:|||||.:.||::.:||.:||.:..|||..|.|.:|...|..|:..||:||||||:.|:
Mouse   220 SPDITPIILAAHCHKYEVVHLLLLKGARIERPHDYFCRCSDCAEKQRLDAFSHSRSRINAYKGLA 284

  Fly   207 ASSLIALSSRDPVLTAFQLSWELKRLQAMESEFRAEYTEMRQMVQDFGTSLLDHARTSMELEVML 271
            :.:.::|||.||||||.:||.||.:|..:|.||:.:|.::....:||...:||..|.|.|:|.:|
Mouse   285 SPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAIL 349

  Fly   272 NFNHEPSHDIWCLGQRQTLERLKLAIRYKQKTFVAHPNVQQLLAAIWYDGLPGFRRKQASQQLMD 336
            |.:.|.:..:...|.:.:|.|:||||:|:.|.||||||.||.|..|||:.|.|.|.:..:.:.:.
Mouse   350 NGDLESAEPLERHGHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLV 414

  Fly   337 VVKLGCSFPIYSLKYILAPDSEGAKFMRKPFVKFITHSCSYMFFL-MLLGAASLRVVQIT----F 396
            |:.:....|..::.|.:||.|...|.:|.||:||:.|:.|::.|| :|:..||.|...||    .
Mouse   415 VLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNI 479

  Fly   397 ELLAFPWML----TMLEDWRKHERGSLPGPIELAIITYIMALIFEELKSLYSDGLFEYIMDLWNI 457
            .::.:|..:    |....|           .|:.|:.:::.:::.|.|.|:.:|..|||:.|||:
Mouse   480 TVIDYPKQIFRVKTTQFTW-----------TEMLIMVWVLGMMWSECKELWLEGPREYIVQLWNV 533

  Fly   458 VDYISNMFYVTWILCRATAWV------------IVHRDLWFRGIDP---YF--PREHWHPFDPML 505
            :|:.....::.....|..|::            :...||....:.|   ||  .|:.|.|.||.:
Mouse   534 LDFGMLSIFIAAFTARFLAFLQATKAQQYVDSHVQESDLSEVTLPPEVQYFTYARDKWLPSDPQI 598

  Fly   506 LSEGAFAAGMVFSYLKLVHIFSINPHLGPLQVSLGRMIIDIIKFFFIYTLVLFAFGCGLNQLLWY 570
            :|||.:|..:|.|:.::.:|...|...||||:||||.:.||.||..::.:|..||..|:..|..|
Mouse   599 ISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFLAFMIGMFILYSY 663

  Fly   571 YAELEKNKCYHLHPDVADFDDQEKACTIWRRFSNLFETSQSLFWASFGLVDLVSFDLAGIKSFTR 635
            |...:.|..                      |:.:.|:.::|||:.|||.::.|..|.....|..
Mouse   664 YLGAKVNPA----------------------FTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIE 706

  Fly   636 FWALLMFGSYSVINIIVLLNMLIAMMSNSYQIISERADTEWKFARSQLWMSYFEDGGTIPPPFNL 700
            ....:::|.|:|..::|||||||||:::|||.|.:.:|.|||||||:||:|||:||.|:||||:|
Mouse   707 NIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSL 771

  Fly   701 CPNMK-----MLRKT-----------------LGRKRPSRTKSFMR-----------KSMERAQT 732
            .|:.|     ::|.|                 :|..: ||...|.:           .|:....|
Mouse   772 VPSPKSFVYFIMRITNFSKCRRRRLQKDLELGMGNSK-SRLNLFTQSNSRVFESHSFNSILNQPT 835

  Fly   733 LHDKVMKLLVRRYITAEQRRRDDYGITEDDIIEVRQDISSLRFELLE 779
            .:.::||.|::||:...|..:::..:.|.::.|::|||||||:||||
Mouse   836 RYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLE 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trp	NP_476768.1	trp	16..776	CDD:273311	278/822 (34%)
		ANK	64..>168	CDD:238125	43/120 (36%)
		ANK repeat	69..98	CDD:293786	9/30 (30%)
		ANK repeat	99..135	CDD:293786	14/50 (28%)
		ANK repeat	137..168	CDD:293786	14/30 (47%)
		TRP_2	178..236	CDD:285535	28/57 (49%)
		BASP1	938..1158	CDD:283191
Trpc3	NP_062383.2	trp	85..879	CDD:273311	278/822 (34%)
		ANK	108..242	CDD:238125	50/141 (35%)
		ANK repeat	135..166	CDD:293786	9/30 (30%)
		ANK repeat	215..250	CDD:293786	16/34 (47%)
		TRP_2	256..315	CDD:285535	28/58 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3609
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.770