DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trp and trp-2

DIOPT Version :9

Sequence 1:	NP_476768.1	Gene:	trp / 43542	FlyBaseID:	FBgn0003861	Length:	1275	Species:	Drosophila melanogaster
Sequence 2:	NP_001022703.1	Gene:	trp-2 / 192056	WormBaseID:	WBGene00006615	Length:	886	Species:	Caenorhabditis elegans

Alignment Length:	928	Identity:	381/928 - (41%)
Similarity:	529/928 - (57%)	Gaps:	128/928 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TESDAEKALGSRLDYDLMMAEEYILSDVEKNFILSCERGDLPGVKKILEEYQGTDKFNINCTDPM 69
            ||||     .|||.              ||.|:|||||||:..|:|:|... .|:.|||||.||:
Worm    25 TESD-----NSRLR--------------EKQFLLSCERGDIGSVRKLLAGI-STETFNINCLDPL 69

  Fly    70 NRSALISAIENENFDLMVILLEHNIEVGDALLHAISEEYVEAVEELLQWEETNHK-EGQPYSWEA 133
            .|:||:.||||||.:::.:||:||||.|||:|:||.||.|||||.:::..|...| :.:....|.
Worm    70 GRNALLIAIENENIEMIELLLDHNIETGDAILYAIGEENVEAVEIIVEHLEKMDKFDSERQGVEI 134

  Fly   134 VDRSKSTFTVDITPLILAAHRNNYEILKILLDRGATLPMPHDVKCGCDECVTSQMTDSLRHSQSR 198
            .:.  |.||.||||::||||::|||.:|:.||:..|:|.||||:|.|.||..::..||||.|:||
Worm   135 TEH--SAFTPDITPIVLAAHKDNYECIKLFLDKKGTVPHPHDVRCSCPECYVAREEDSLRLSRSR 197

  Fly   199 INAYRALSASSLIALSSRDPVLTAFQLSWELKRLQAMESEFRAEYTEMRQMVQDFGTSLLDHART 263
            |||||||::.|||.||:|||:|.||:||||||||..:|:|||.:|.|:.|..|.|...:||..|.
Worm   198 INAYRALTSPSLICLSARDPILYAFELSWELKRLSFIENEFRTDYEELSQKCQKFCVHMLDQVRG 262

  Fly   264 SMELEVMLNFNHEPSHDIWC--LGQRQTLERLKLAIRYKQKTFVAHPNVQQLLAAIWYDGLPGFR 326
            |.||||:||......||:..  .|..:.|.||||||:..||.||||||.||||..|||:|:...|
Worm   263 SKELEVVLNHTTNAWHDVTSANYGNPEKLARLKLAIQLSQKRFVAHPNCQQLLLDIWYEGVESVR 327

  Fly   327 RKQASQQLMDVVKLGCSFPIYSLKYILAPDSEGAKFMRKPFVKFITHSCSYMFFLMLLGAASLRV 391
            ......:|:..:....|||::||.|:|||.|...:|.:|||:||::||.||:|||:||..||.|:
Worm   328 CTNFIYKLIFYILGMLSFPLFSLVYLLAPHSSMGQFAKKPFIKFLSHSGSYIFFLILLIMASQRM 392

  Fly   392 VQITFELLAFPWMLTMLEDW-RKHERGSLPGPIELAIITYIMALIFEELKSLYSDGLFEYIMDLW 455
            ..|.        .:...:|. ||..||..|..||.||..:::.||:.|:|.|:..||:.|..:||
Worm   393 NVID--------NILRTDDVDRKETRGPPPTIIECAIFLWVLGLIWVEIKQLWECGLYNYCRNLW 449

  Fly   456 NIVDYISNMFYVTWILCRATAWVIVHRDLWFRG----IDPYFPREHWHPFDPMLLSEGAFAAGMV 516
            ||:|:|:|..|:.....|..|:|.|.::. .|.    |..:.||..|..:||.||||..||...:
Worm   450 NILDFITNSLYLCTTALRVVAYVQVEQEA-LRANSVHIARHLPRRDWDAWDPTLLSECFFATANI 513

  Fly   517 FSYLKLVHIFSINPHLGPLQVSLGRMIIDIIKFFFIYTLVLFAFGCGLNQLLWYYAELEKNKC-- 579
            ||.|||||||:::||||||::|||||:|||:|||.:|.||||||.|||||||||||.:.:|:|
Worm   514 FSSLKLVHIFTVSPHLGPLKISLGRMVIDIVKFFMVYALVLFAFACGLNQLLWYYASMRQNECNL 578

  Fly   580 YHLHPDVADF-----------DDQEKACTIWRRFSNLFETSQSLFWASFGLVDLVSFDLAGIKSF 633
            |..:.:....           ||:.|:|      |:::.|:::||||.||||||..|.|......
Worm   579 YEQYKNEKSLSYKYEHLKESCDDKYKSC------SSIYHTAETLFWALFGLVDLTHFRLKEDHFL 637

  Fly   634 TRFWALLMFGSYSVINIIVLLNMLIAMMSNSYQIISERADTEWKFARSQLWMSYFEDGGTIPPPF 698
            :.:....:||||...:|||||||||||||||||.||::||.|||||||:|::.||:|..|:||||
Worm   638 SEWTGKTIFGSYCCCSIIVLLNMLIAMMSNSYQYISDQADIEWKFARSRLFLEYFDDTATLPPPF 702

  Fly   699 NLCPNMK-------MLRKTLGR----KRPSRTKSFMRKSMERAQTLHDKVMKLLVRRYITAEQRR 752
            |:.|:.|       .|.|.|..    ::||:.||...:|                 :.:...||.
Worm   703 NIVPSPKSIYYCLHYLTKKLCNCTKLQQPSKQKSMRVES-----------------KNLAIRQRP 750

  Fly   753 RDDYGITEDDIIEVRQDISSLRFELLEIFTNNNWDVPDIEKKSQGVARTTKGKVMERRILKDF-- 815
            |.          ::.::.:..|:...:..:.|       :||:....|..|...:   :||:|
Worm   751 RK----------QLPENCAKNRYSGAQFHSRN-------KKKTAMAERRLKNSAL---LLKEFPV 795

  Fly   816 -----------QIGFVEN---LKQEMSESESGRDIFSSLAKVIGRKKTQKGDKDWNAIARKNTFA 866
                       .|..:::   ||.....|.|.....:...|.....|::..|.....:.|.:..
Worm   796 PQMFKAGQRNMSISSIQSNGRLKPSFMPSSSKLSWSNLKVKASRLSKSKSIDTTHLDVTRLHAL- 859

  Fly   867 SDPIGSKRSSMQRHSQRS 884
                 ||:|.:|:.:..|
Worm   860 -----SKKSPLQKQAHTS 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trp	NP_476768.1	trp	16..776	CDD:273311	354/791 (45%)
		ANK	64..>168	CDD:238125	52/104 (50%)
		ANK repeat	69..98	CDD:293786	15/28 (54%)
		ANK repeat	99..135	CDD:293786	14/36 (39%)
		ANK repeat	137..168	CDD:293786	17/30 (57%)
		TRP_2	178..236	CDD:285535	37/57 (65%)
		BASP1	938..1158	CDD:283191
trp-2	NP_001022703.1	trp	34..757	CDD:273311	351/767 (46%)
		ANK	37..163	CDD:238125	65/128 (51%)
		ANK repeat	69..96	CDD:293786	14/26 (54%)
		TRP_2	177..236	CDD:285535	37/58 (64%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159953
Domainoid	1	1.000	280	1.000	Domainoid score	I888
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	722	1.000	Inparanoid score	I326
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D824310at2759
OrthoFinder	1	1.000	-	-		FOG0000660
OrthoInspector	1	1.000	-	-		otm14461
orthoMCL	1	0.900	-	-		OOG6_102173
Panther	1	1.100	-	-	O	PTHR10117
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X802
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.900