DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trp and trp-4

DIOPT Version :9

Sequence 1:	NP_476768.1	Gene:	trp / 43542	FlyBaseID:	FBgn0003861	Length:	1275	Species:	Drosophila melanogaster
Sequence 2:	NP_493429.2	Gene:	trp-4 / 190574	WormBaseID:	WBGene00006616	Length:	1924	Species:	Caenorhabditis elegans

Alignment Length:	721	Identity:	153/721 - (21%)
Similarity:	285/721 - (39%)	Gaps:	152/721 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LSCERGDLPGVKKILEEYQGTDKFNINCTDPMNRSALISAIENENFDLMVILLEH--NIEVGD-- 98
            |:.::|.:..|..:|.  :.|.:  .:..|...|:.|..|.:|.:::::.:|:..  ||.|.|
Worm  1245 LAAQQGHIAVVGMLLS--RSTQQ--QHAKDWRGRTPLHLAAQNGHYEMVSLLIAQGSNINVMDQN 1305

  Fly    99 --ALLH--------AISEEYVEAVEELLQWEETNHKEGQPYSWEAVDRSKSTFTVDITPLILAAH 153
              ..||        ::.:.::::..:.|  .||  |||:                  .||..||.
Worm  1306 GWTGLHFATRAGHLSVVKLFIDSSADPL--AET--KEGK------------------VPLCFAAA 1348

  Fly   154 RNNYEILKILL-DRGATLPMPHDVKCGCDECVTSQMTDSLRHSQSRINAYRALSASSLIALSSRD 217
            .|:.|.|:.|| .:..|..:..|.|...|..|..:..|:              .......|.|..
Worm  1349 HNHIECLRFLLKQKHDTHQLMEDRKFIFDLMVCGKTNDN--------------EPLQEFILQSPA 1399

  Fly   218 PVLTAFQLSWELKRLQAMESEFRAEYTEMRQMVQDFGTSLLDHARTSMELEVMLNFNHEPSHDIW 282
            |:.||.:||...:.:...|.|...:...:....::....||....|.....::|.........:
Worm  1400 PIETAVKLSALYRDMSEKEKERAKDLLNVAVFSENMAVELLGITATEYNAALLLKAKDNRGRPL- 1463

  Fly   283 CLGQRQTLERLKLAIRYKQKTFVAHPNVQQLLAAIWYDGLPGFRRKQASQQLMDVVKLGCS---F 344
                      |.:.|..:||..|::.:||:.|..:|                  ..::..|   |
Worm  1464 ----------LDVLIENEQKEVVSYASVQRYLTEVW------------------TARVDWSFGKF 1500

  Fly   345 PIYSLKYILAP----------DSEGAKFMRKPFVKFITHSCSYMFFLMLLGAASLRVVQITFELL 399
            ..:||..::.|          ||   :..|.|.:||:.|..|:::|.:||....|.:....:|:.
Worm  1501 VAFSLFVLICPPAWFYFSLPLDS---RIGRAPIIKFVCHIVSHVYFTILLTIVVLNITHKMYEVT 1562

  Fly   400 AFPWMLTMLEDWRKHERGSLPGPIELAIITYIMALIFEELKSLYSDGLFEYIMDLWNIVDYISNM 464
            :.                 :|.|:|..::.::...:..||.::........:..|..::..::..
Worm  1563 SV-----------------VPNPVEWLLLLWLSGNLVSELSTVGGGSGLGIVKVLILVLSAMAIA 1610

  Fly   465 FYVTWILCRATAWVIVHRDLWFRGIDPYFPREHWHPFDPML-LSEGAFAAGMVFSYLKLVHIFSI 528
            .:|...|..|.  .:.|.|          ..|..|....|| |....||..::|::::.:...::
Worm  1611 VHVLAFLLPAV--FLTHLD----------NDEKLHFARTMLYLKNQLFAFALLFAFVEYLDFLTV 1663

  Fly   529 NPHLGPLQVSLGRMIIDIIKFFFIYTLVLFAFGCGLNQLLWYYAELEKNKCYHLHPDVADFDDQE 593
            :...||..:.:..::.|:.:|..|  |:||..|..|:....:....:.          .|.|..|
Worm  1664 HHLFGPWAIIIRDLMYDLARFLVI--LMLFVAGFTLHVTSIFQPAYQP----------VDEDSAE 1716

  Fly   594 KACTIWRRFSNLFETSQSLFWASFGLVDLVSF-DLAGIKSFTRFWALLMFGSYSVINIIVLLNML 657
                 ..|.::..:|.:.||::.||||:..|. .|..:..|.:....|:||.|.::.:|||:|:|
Worm  1717 -----LMRLASPSQTLEMLFFSLFGLVEPDSMPPLHLVPDFAKIILKLLFGIYMMVTLIVLINLL 1776

  Fly   658 IAMMSNSYQIISERADTEWKFARSQLWMSYFEDGGTIPPPFNLCPNMKMLRKTLGRKRPSRTKSF 722
            |||||::||.|..::|.||||.|:.|.....:...| |.|.|:...:.::.:...|   :|.:..
Worm  1777 IAMMSDTYQRIQAQSDKEWKFGRAILIRQMNKKSAT-PSPINMLTKLIIVLRVAWR---NRLRCM 1837

  Fly   723 MRKSME 728
            .||:.:
Worm  1838 TRKAQD 1843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trp	NP_476768.1	trp	16..776	CDD:273311	153/721 (21%)
		ANK	64..>168	CDD:238125	27/118 (23%)
		ANK repeat	69..98	CDD:293786	8/30 (27%)
		ANK repeat	99..135	CDD:293786	8/43 (19%)
		ANK repeat	137..168	CDD:293786	9/31 (29%)
		TRP_2	178..236	CDD:285535	10/57 (18%)
		BASP1	938..1158	CDD:283191
trp-4	NP_493429.2	ANK repeat	804..842	CDD:293786
		ANK repeat	849..884	CDD:293786
		ANK repeat	886..917	CDD:293786
		ANK repeat	919..950	CDD:293786
		ANK repeat	952..982	CDD:293786
		ANK repeat	986..1017	CDD:293786
		PHA03095	1006..>1336	CDD:222980	18/96 (19%)
		ANK repeat	1092..1123	CDD:293786
		ANK repeat	1204..1236	CDD:293786
		trp	1209..1879	CDD:273311	153/721 (21%)
		ANK repeat	1238..1270	CDD:293786	5/28 (18%)
		ANK repeat	1272..1303	CDD:293786	8/30 (27%)
		ANK repeat	1305..1336	CDD:293786	3/32 (9%)
		ANK repeat	1338..1366	CDD:293786	11/45 (24%)
		ANKYR	280..515	CDD:223738
		ANK repeat	352..383	CDD:293786
		ANK repeat	385..418	CDD:293786
		ANK repeat	424..454	CDD:293786
		PHA03095	430..>756	CDD:222980
		ANK repeat	456..489	CDD:293786
		ANK repeat	491..523	CDD:293786
		ANK repeat	526..556	CDD:293786
		ANK repeat	558..590	CDD:293786
		ANK repeat	592..623	CDD:293786
		ANK repeat	625..656	CDD:293786
		ANK repeat	658..688	CDD:293786
		ANK repeat	692..726	CDD:293786
		PHA02876	<712..>1040	CDD:165207
		ANK repeat	728..753	CDD:293786
		ANK repeat	761..802	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3609
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810