Protein Alignment trp and trp-1

DIOPT Version :9

• Sequence 1: NP_476768.1
• Gene: trp / 43542
• FlyBaseID: FBgn0003861
• Length: 1275
• Species: Drosophila melanogaster
• Sequence 2: NP_001367402.1
• Gene: trp-1 / 176202
• WormBaseID: WBGene00006614
• Length: 1031
• Species: Caenorhabditis elegans
• Alignment Length: 1085
• Identity: 329/1085 - (30%)
• Similarity: 540/1085 - (49%)
• Gaps: 193/1085 - (17%)

  Fly    28 ILSDVEKNFILSCERGDLPGVKKILEEYQGTDKFNINCTDPMNRSALISAIENENFDLMVILLEH 92
            ::|..|:.|:.:.|.|:.|.:::.| :|.|..:.|:||.|.|.|:||..|::|||.:::.:||:.
 Worm    49 MISPEERRFLEAAELGNKPTLQECL-DYDGDRRLNVNCLDSMGRTALEIAVDNENMEVVELLLQQ 112

  Fly    93 -NIEVGDALLHAISEEYVEAVEELLQWEETNHKE------GQPYSWEAVDRSKST---FTVDITP 147
             :|.:|:|||.||.|.....||.|:     ||..      |..:| :|:|.|::.   ::.||:|
 Worm   113 PDIRIGNALLCAIREGVYRLVEVLV-----NHPNITREMLGDGWS-QALDPSEAASAEYSSDISP 171

  Fly   148 LILAAHRNNYEILKILLDRGATLPMPHDVKCGCDECVTSQMTDSLRHSQSRINAYRALSASSLIA 212
            :||||..|.:|||::|:.:.|::..||...|.|:.|...::.|||::|..|||.:|||::.:.::
 Worm   172 VILAAQLNQFEILQMLIRKDASIEKPHRHSCICETCDRERLNDSLQYSLKRINTFRALASPAWMS 236

  Fly   213 LSSRDPVLTAFQLSWELKRLQAMESEFRAEYTEMRQMVQDFGTSLLDHARTSMELEVMLNFN--- 274
            |:|.||:|:||:|||:|:||...|.||:..|.::.:..:.:...||...|:|.|:..:||.:
 Worm   237 LTSPDPILSAFKLSWDLQRLAFEEHEFKETYLQLSEQCKQYSCDLLSQCRSSEEVIAILNKDGNV 301

  Fly   275 HEPSHDIWCLGQRQTLERLKLAIRYKQKTFVAHPNVQQLLAAIWYDGLPGFRRKQASQQLMDVVK 339
            ::.:.|:|  ..:.:|.||||||:|:||.||:||:.||||.:|||:|:|..:|............
 Worm   302 NDDNIDVW--ASKLSLSRLKLAIKYEQKAFVSHPHCQQLLTSIWYEGIPYRQRSGTWANFFLYAF 364

  Fly   340 LGCSFPIYSLKYILAPDSEGAKFMRKPFVKFITHSCSYMFFLMLLGAASLRVVQITFELLAFPWM 404
            |...:||:.|.|||.|.|...:.:|.||:||..:|.|:..||.||..|       ||
 Worm   365 LLFLWPIFCLMYILMPKSRLGRLVRSPFMKFFYYSVSFATFLGLLTWA-------TF-------- 414

  Fly   405 LTMLEDWR--KHERGSLP-----GP----IELAIITYIMALIFEELKSLYSDGLFEYIMDLWNIV 458
                ||:|  |.|||.:.     ||    :|..:.|:::.:::.|:|.|:.:|...|:...||.:
 Worm   415 ----EDYRYEKGERGGMTRASDRGPPATWVESLVFTWVIGMLWSEIKQLWEEGFKRYMRQWWNWL 475

  Fly   459 DYISNMFYVTWILCRATA-WVIVHRDLWFRGIDP--YFPREHWHPFDPMLLSEGAFAAGMVFSYL 520
            |::....|:..|..|.:| ::..:|:      ||  |..|.:|...:|||::|..||.|.|||:.
 Worm   476 DFLMICLYLCTISIRLSAYYIFTYRE------DPYRYTVRTYWTSEEPMLVAEALFAVGNVFSFA 534

  Fly   521 KLVHIFSINPHLGPLQVSLGRMIIDIIKFFFIYTLVLFAFGCGLNQLLWYYAE-----LEKNKCY 580
            :::::|..||:|||||:|||.|::|:.||.||:.|::.:|..||.||.|||..     |....|.
 Worm   535 RIIYLFQTNPYLGPLQISLGCMLVDVAKFCFIFVLIISSFSIGLAQLYWYYDPNTDVCLPGATCK 599

  Fly   581 HLHPDVADFDDQEKACTIWRRFSNLFETSQSLFWASFGLVDLVSFDLAGIKSFTRFWALLMFGSY 645
            |..                ..||::.::..:|.|:.|.:......|:......|::....||..|
 Worm   600 HSS----------------NVFSSIADSYLTLLWSLFSITKPEDTDVVENHKITQWVGQGMFIMY 648

  Fly   646 SVINIIVLLNMLIAMMSNSYQIISERADTEWKFARSQLWMSYFEDGGTIPPPFNLCPNMKML--- 707
            ...:|||||||||||||:|:|||::.||.||||.|::|||::|::|.::|||||:....|.|
 Worm   649 HCTSIIVLLNMLIAMMSHSFQIINDHADLEWKFHRTKLWMAHFDEGSSLPPPFNIIVTPKSLIYV 713

  Fly   708 --------RKTLGR------------KRPSRTKSFMRKSMERAQTLHDKVMK---------LLVR 743
                    |..||:            :||..::.  |..||::....|..:|         .||.
 Worm   714 MNCLFNTVRWLLGKYTYQKNRNRATIRRPGYSRK--RNEMEKSGGHDDDSLKPLTYADIITRLVA 776

  Fly   744 RYI--TAEQRRRDDYGITEDDIIEVRQDISSLRFELLE------IFTNNNWDV--PDIEKKSQGV 798
            |:|  |.:..:.|  |:.|||:.|::|||||||:||.:      :.::::.|.  .||.:.....
 Worm   777 RFIHQTKKDMKMD--GVNEDDLHEIKQDISSLRYELRDDRRREIVRSSSHIDAVKRDIMRTMSTT 839

  Fly   799 ARTTKGKVMERRILKDFQIGFVENLKQEMSESESGRDIFSSLAKVIGRKKTQKGDKDWNAIARKN 863
            :|...|..|  |:.|      ......|.||.:...|..||..:.....:::|          .:
 Worm   840 SRRPYGGSM--RLPK------TRPSVAEESEEDDKSDETSSTDEEADETRSRK----------SS 886

  Fly   864 TFASDPIGS------------KRSSMQRHSQRSLRRKIIEQANEGLQMNQTQLIEFNPNLGDVTR 916
            .....|:.|            |:|:.:|.|:..  .|:.::     .::.|....|.|.|..|
 Worm   887 VLYIPPVNSTLPGIISEEAPVKKSTKRRASEAD--SKLPDR-----PLSDTYTSSFTPKLLPV-- 942

  Fly   917 ATRVAYVKFMRKKMAADEVSLADDEGAPNGEGEKKPLDASGSKKSITSGGTGGGASMLAAAALRA 981
                 :.:.....:...:.|::            .|::.:....||.....|         .|||
 Worm   943 -----FAQPPHSALRKTDTSMS------------FPINGTALDTSIVKPPRG---------VLRA 981

  Fly   982 SVKNVDEKSGADGKPGTMGKPTDDKKAGDDKDKQQPPKDSKPSAG 1026
            |.:|:......:.....|.:..|...:|..::.:.|...|....|
 Worm   982 SQENLPAVELIETLKKEMNEKLDRLISGISENVKSPSPASHSHVG 1026

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trp	NP_476768.1	trp	16..776	CDD:273311	284/813 (35%)
		ANK	64..>168	CDD:238125	43/113 (38%)
		ANK repeat	69..98	CDD:293786	11/29 (38%)
		ANK repeat	99..135	CDD:293786	14/41 (34%)
		ANK repeat	137..168	CDD:293786	13/33 (39%)
		TRP_2	178..236	CDD:285535	26/57 (46%)
		BASP1	938..1158	CDD:283191	15/89 (17%)
trp-1	NP_001367402.1	trp	38..809	CDD:273311	284/813 (35%)
		ANK repeat	89..119	CDD:293786	11/29 (38%)
		ANK repeat	149..195	CDD:293786	17/46 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000660
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102173
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810