DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trp and trpc7b

DIOPT Version :9

Sequence 1:	NP_476768.1	Gene:	trp / 43542	FlyBaseID:	FBgn0003861	Length:	1275	Species:	Drosophila melanogaster
Sequence 2:	NP_001276815.1	Gene:	trpc7b / 102725540	ZFINID:	ZDB-GENE-140129-2	Length:	844	Species:	Danio rerio

Alignment Length:	865	Identity:	290/865 - (33%)
Similarity:	450/865 - (52%)	Gaps:	144/865 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LSDVEKNFILSCERGDLPGVKKILEEYQGTDKFNINCTDPMNRSALISAIENENFDLMVILLEHN 93
            |:..|:.|:.:.|.|::|.|:|:|:|   :...|.||.|.|.::||..|:.||:.::..:||:.:
Zfish    31 LTAEEERFMDAAEYGNIPVVRKMLDE---SKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKD 92

  Fly    94 --IEVGDALLHAISEEYVEAVEELLQWEETNH---------------KEGQPYSWEAVDRSKSTF 141
              ..:|||||.|||:.||..||.:|.     |               :|.:...:.|.|...:.|
Zfish    93 GMARIGDALLLAISKGYVRIVEAILA-----HPAFAGGLRLTLSPLEQELRDDDFYAYDEDGTRF 152

  Fly   142 TVDITPLILAAHRNNYEILKILLDRGATLPMPHDVKCGCDECVTSQMTDSLRHSQSRINAYRALS 206
            :.|:||:|||||...|||:.|||.:||.:..|||..|.|:||:..|..||..||:||:|||:.|:
Zfish   153 SHDVTPVILAAHCQEYEIVHILLMKGARIERPHDYFCKCNECMEKQRRDSFSHSRSRMNAYKGLA 217

  Fly   207 ASSLIALSSRDPVLTAFQLSWELKRLQAMESEFRAEYTEMRQMVQDFGTSLLDHARTSMELEVML 271
            :::.::|||.||||||.:||.||.||..:|:||:.:|.::....:||...:||..|.:.|:|.:|
Zfish   218 SAAYLSLSSEDPVLTALELSNELARLANIETEFKNDYRKLSMQCKDFVVGVLDLCRDTEEVEAIL 282

  Fly   272 N--FNHEPSHDIWCLGQRQTLERLKLAIRYKQKTFVAHPNVQQLLAAIWYDGLPGFRRKQASQQL 334
            |  .:..|..::    ||..|.|:||:|:|:.|.||||||.||.|..|||:.|.|.|::....:.
Zfish   283 NGDVDQNPPAEL----QRPCLSRIKLSIKYEVKKFVAHPNCQQQLLTIWYENLSGLRQQSIGVKC 343

  Fly   335 MDVVKLGCSFPIYSLKYILAPDSEGAKFMRKPFVKFITHSCSYMFFLMLL---------GAASLR 390
            :.|:.:....|..::.|.:.|.|:..:.:|.||:||:.|:.|:..||.||         |..:|.
Zfish   344 LTVLGVTVGLPFLAIAYWIMPCSKLGQILRSPFMKFVAHAVSFTIFLALLVLNASDRFEGVKNLP 408

  Fly   391 VVQIT--------FELLAFPWMLTMLEDWRKHERGSLPGPIELAIITYIMALIFEELKSLYSDGL 447
            ...||        .:...|.|                   .||.|:.:::.:|:.|.|.::.||.
Zfish   409 NETITDHPRQVFRVKTTQFSW-------------------TELLIMKWVLGMIWSECKEIWVDGP 454

  Fly   448 FEYIMDLWNIVDYISNMFYVTWILCRATAWVIVHR-----DLWFRGID----------PYF--PR 495
            .||:|.|||::|:.....:|.....|..|::...:     ||.....|          .||  .|
Zfish   455 REYVMHLWNVLDFGMLSIFVASFTARLMAFLKASKAQLYVDLHVPNHDISNASLPADVAYFTYAR 519

  Fly   496 EHWHPFDPMLLSEGAFAAGMVFSYLKLVHIFSINPHLGPLQVSLGRMIIDIIKFFFIYTLVLFAF 560
            ..|.|.||.::|||.:|..:|.|:.::.:|...|...||||:||||.:.||.||..|:.:|..||
Zfish   520 NRWRPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAF 584

  Fly   561 GCGLNQLLWYYAELEKNKCYHLHPDVADFDDQEKACTIWRRFSNLFETSQSLFWASFGLVDLVSF 625
            ..|:..|..||...:.|..                      |:.:.|:.::|||:.|||.:::|.
Zfish   585 MIGMFNLYSYYLGAKYNPA----------------------FTTVEESFKTLFWSIFGLSEVISV 627

  Fly   626 DLAGIKSFTRFWALLMFGSYSVINIIVLLNMLIAMMSNSYQIISERADTEWKFARSQLWMSYFED 690
            .|.....|......:::|.|:|..::|||||||||:::|||.|.|.||.||||||::||:|||::
Zfish   628 VLKYDHKFIENIGYVLYGVYNVTMVVVLLNMLIAMINSSYQEIEEDADVEWKFARAKLWLSYFDE 692

  Fly   691 GGTIPPPFNLCPNMKML---------------------------------RKTLGRKR---PSRT 719
            |.|:|.||||.|..|..                                 |:.:.|.|   .||.
Zfish   693 GRTLPAPFNLVPTPKSFYYLIIRIKTCLIHLCKGKAHRHDSELEMGMINSRQKVDRHRVNLRSRE 757

  Fly   720 KSFMRKSMERAQTLHDKVMKLLVRRYITAEQRRRDDYGITEDDIIEVRQDISSLRFELLEIFTNN 784
            :|.::|.::. .|.:.|:||.|::||:...|..|::..:.|.::.|::|||||||:||||..:..
Zfish   758 ESTLKKPIKH-PTRYQKIMKRLIKRYVLKAQVDRENDEVNEGELKEIKQDISSLRYELLEEKSQA 821

  Fly   785 NWDVPD-IEKKSQGVARTTK 803
            ..::.| |::.|....|..|
Zfish   822 TGELADLIQQLSDKFGRNAK 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trp	NP_476768.1	trp	16..776	CDD:273311	281/835 (34%)
		ANK	64..>168	CDD:238125	43/120 (36%)
		ANK repeat	69..98	CDD:293786	8/30 (27%)
		ANK repeat	99..135	CDD:293786	14/50 (28%)
		ANK repeat	137..168	CDD:293786	15/30 (50%)
		TRP_2	178..236	CDD:285535	30/57 (53%)
		BASP1	938..1158	CDD:283191
trpc7b	NP_001276815.1	trp	18..813	CDD:273311	281/835 (34%)
		ANK repeat	38..66	CDD:293786	11/30 (37%)
		ANK	41..175	CDD:238125	49/141 (35%)
		ANK repeat	68..99	CDD:293786	8/30 (27%)
		ANK repeat	100..146	CDD:293786	14/50 (28%)
		ANK repeat	148..183	CDD:293786	17/34 (50%)
		TRP_2	189..247	CDD:285535	30/57 (53%)
		TPX2_importin	724..>794	CDD:289022	16/70 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910